본문 바로가기
KERD
논문KCI 등재

Leptospirosis in the Republic of Korea: Historical Perspectives, Current Status and Future Challenges

김민자
대한감염학회 (The Korean Society Of Infectious Diseases)|2013.06|Infection and Chemotherapy|제45권 제2호|pp. 137-144

1

조회

0

다운로드

5

인용

0

참고문헌

키워드

EpidemiologyReservoirsPulmonary hemorrhageLeptospira
주제분류내과학

초록

Leptospirosis is an important public health problem in the Republic of Korea (ROK), occurring sporadically or in outbreaks during the autumn season. Wild rodents, Apodemus agrarius, have been mainly involved in human leptospirosis. The majority of carrier animals are infected with Leptospira interrogans serovar lai . The characteristic pulmonary involvement or hemorrhage may increase the clinical severity or result in fatal outcomes, and these aspects continue to be a threat to people in endemic areas. While the disease incidence has been relatively low in recent years, there have been newer findings of livestock (zoo animals and racing horses) and rats (Rattus norvegicus ) captured in urban environments as potential animal carriers. Many avenues of research are still open to define current changes in ecology, epidemiology, and the disease burden in both humans and animals in the ROK, together with global warming and climate change issues. In addition, national policy regarding the weighted wildlife monitoring system and the enhanced disease surveillance program is required to facilitate better monitoring and understanding of this disease.

Abstract

Leptospirosis is an important public health problem in the Republic of Korea (ROK), occurring sporadically or in outbreaks during the autumn season. Wild rodents, Apodemus agrarius, have been mainly involved in human leptospirosis. The majority of carrier animals are infected with Leptospira interrogans serovar lai . The characteristic pulmonary involvement or hemorrhage may increase the clinical severity or result in fatal outcomes, and these aspects continue to be a threat to people in endemic areas. While the disease incidence has been relatively low in recent years, there have been newer findings of livestock (zoo animals and racing horses) and rats (Rattus norvegicus ) captured in urban environments as potential animal carriers. Many avenues of research are still open to define current changes in ecology, epidemiology, and the disease burden in both humans and animals in the ROK, together with global warming and climate change issues. In addition, national policy regarding the weighted wildlife monitoring system and the enhanced disease surveillance program is required to facilitate better monitoring and understanding of this disease.

참고문헌 (61)

  1. Smadel JE, "Epidemic hemorrhagic fever", Am J PublicHealth, 43, pp.1327~1330 (1953)
  2. Lee HW, "Isolation of the etiologicagent of Korean Hemor rhagic fever", J Infect Dis, 137, pp.298~308 (1978)
  3. Cho MK, "Bacteriological studies onleptospirosis in Korea", Korean J Epidemiol, 6, pp.16~35 (1984)
  4. Lee WY, "Leptospira interrogans"Korea" isolated from patients with epidemic pulmonaryhemorrhagic fever", Korean J Epidemiol, 6, pp.36~46 (1984)
  5. Lee JS, "Thirteen cases of rickettsialinfection including nine cases of tsutsugamushi disease firstconfirmed in Korea", J Korean Med Assoc, 29, pp.430~438 (1986)
  6. Lyi KS, "Clinical features of the patients with tsutsugamushidisease occurred in Chinhae area", Korean J Infect Dis, 18, pp.93~97 (1986)
  7. Lee HW, "Hemorrhagic fever with renal syndrome in Korea", Rev Infect Dis, 11(4), pp.S864~S876 (1989)
  8. Faine S, "Leptospira and leptospirosis", pp.121~144 (1994), CRC Press Inc
  9. Adler B, "Leptospira and leptospirosis", Vet Microbiol, 140, pp.287~296 (2010)
  10. Faine S, "Leptospirosis-here, now", Pathology, 13, pp.1~5 (1981)
  11. Faine S, "Leptospira and leptospirosis", pp.253~257 (1994), CRC Press Inc
  12. Park SC, "An epidemiological study on the epidemic pneumonitis,occurred in Ryeo-Ju and I-Cheon, central area of Korea,1975", J Korean Med Assoc, 19, pp.263~268 (1976)
  13. Nam SD, "Epidemiological pattern of acute endemic respiratorydiseases", J Korean Med Assoc, 19, pp.269~273 (1976)
  14. Kim KH, "Clinicalpictures of the haemorrhagic pneumonia-like diseasewhich occurred epidemically in the central area of Koreain autumn, 1975", J Korean Med Assoc, 19, pp.274~286 (1976)
  15. Chae IS, "An epidemiological,clinical and radiological study on the epidemicpneumonitis, which occurred in the central area of Koreain autumn, 1975", J Korean Med Assoc, 19, pp.287~292 (1976)
  16. Kim KS, "On the radiologic findings", J Korean Med Assoc, 19, pp.298~302 (1976)
  17. Han WS, "Autopsy and postmortem needle biopsyfindings of pneumonitis-like disease", J Korean Med Assoc, 19, pp.303~306 (1976)
  18. Moon GJ, "The gross and histopathological findings", J KoreanMed Assoc, 19, pp.307~309 (1976)
  19. Bahk YW, "Radiologic manifestationof pneumonia-like disease occurred epidemically inthe central area of Korea in autumn, 1975", J Korean MedAssoc, 19, pp.293~297 (1976)
  20. Shim YH, "Epidemic pulmonary hemorrhagic fever: I. Epidemiologicaland clinical observation", J Korean Med Assoc, 23, pp.131~144 (1980)
  21. Choe KH, "Epidemic pulmonary hemorrhagicfever: II. Retrospective study (1970-1974)", J KoreanMed Assoc, 23, pp.145~150 (1980)
  22. Kim JS, "An analytic epidemiological study to test the hypothesis,leptospirosis as the cause of the epidemic pulmonaryhemorrhagic fever in Korea", Korean J Epidemiol, 6, pp.8~15 (1984)
  23. Oh HB, "Serological analysis of Leptospirainterrogans isolated in Korea by cross-agglutinationabsorption method", J Korean Soc Microbiol, 21, pp.337~343 (1986)
  24. Kim MJ, "Serovar identification of Korean leptospiralstrains with monoclonal antibodies", Korean J Med, 32, pp.571~579 (1987)
  25. Chang WH, "Serological analysis of Leptospirainterrogans isolated in Korea by monoclonal antibodies", J Korean Soc Microbiol, 23, pp.277~292 (1988)
  26. Cho MK, "Serological analysis of Leptospira interrogansisolated in Korea using monoclonal antibodies and crossagglutininabsorption test", J Korean Soc Microbiol, 24, pp.539~548 (1989)
  27. Oh HB, "Identificationof new serovar yeonchon and hongchon belongingto Leptospira interrogans lcterohaemorrhagiae serogroup", J Korean Soc Microbiol, 26, pp.253~262 (1991)
  28. Kim MJ, "Leptospirosis in Korea: Clinicaland epidemiologic Study, Leptospirosis:Proceedings of Leptospirosis Research Conference1990", Japanese Leptospirosis Research Society, pp.88~103 (1991)
  29. Kim SS, "Epiderniologic characteristics and trendsof leptospirosis in Korea by literature review", Korean J Epidemiol, 16, pp.66~83 (1994)
  30. Cho MK, "Characterization of Leptospira interrogans isolatedin Korea and seroepidemiological study on leptospirosis(1984-1987)", J Korean Med Assoc, 31, pp.612~622 (1988)
  31. Lee SJ, "A seroepidemiologicalstudy on leptospiral infection in a ruralcommunity", Korean J Epidemiol, 14, pp.79~90 (1992)
  32. Chang WH, "Seroepidemiologicalsurvey of the leptospirosis in Korea, 1986-1991", J Korea Soc Microbiol, 28, pp.13~22 (1993)
  33. Kim MJ, "Clinical features of serologicallyproven leptospirosis in Korea and changes in leptospiralagglutinin titer", Korean J Med, 32, pp.188~197 (1987)
  34. Im JG, "Leptospirosis of the lung: radiographicfindings in 58 patients", AJR Am J Roentgenol, 152, pp.955~959 (1989)
  35. Lee JS, "Clinical studies on leptospirosisin Korea", J Korean Med Assoc, 29, pp.537~547 (1986)
  36. Park SK, "Leptospirosis in Chonbuk Province of Korea in 1987: a study of 93 patients", Am J Trop Med Hyg1989, 41, pp.345~351 (1989)
  37. Kim JK, "The 155cases of leptospirosis in Kwangju and Chonnam provincefor recent 4 years", Korean J Intern Med, 42, pp.239~245 (1992)
  38. Silverstein CM, "Pulmonary manifestations of leptospirosis", Radiology, 61, pp.327~334 (1953)
  39. McBride AJ, "Leptospirosis", Curr Opin Infect Dis, 18, pp.376~386 (2005)
  40. Medeiros Fda R, "Leptospirosisassociateddisturbances of blood vessels, lungs and hemostasis", Acta Trop, 115, pp.155~162 (2010)
  41. Oh MD, "Milestones in history of adult vaccinationin Korea", Clin Exp Vaccine Res, 1, pp.9~17 (2012)
  42. Korea Centers for Disease Control and Prevention, "Infectiousdisease surveillance yearbook, 2011", PHWR PublicHealth Weekly Report, 5, pp.58~341 (2012), PHWR PublicHealth Weekly Report
  43. Chang WG, "An epidemiological andclinical study of leptospirosis acquired by twelves combatpolicemen in september, 2000", Korean J Med, 61, pp.553~561 (2001)
  44. 강승지, "최근 7년간 일개 대학병원에서 경험한 렙토스피라병의 임상적 고찰", 대한내과학회지, 77(4), pp.453~460 (2009), 대한내과학회
  45. Zhang C, "Leptospirosis prevalence in Chinesepopulations in the last two decades", Microbes Infect, 14, pp.317~323 (2012)
  46. Cho MK, "Infection rate of Leptospirainterrogans in the field rodent, Apodemus agrarius,in Korea", Epidemiol Infect, 121, pp.685~690 (1998)
  47. Song JW, "Seroepidemiologicanalysis of acute febrile illness during1994-1995 in Korea", Korean J Infect Dis, 30, pp.385~391 (1998)
  48. Song JW, "Seroepidemiologicanalysis of acute febrile illness from Korea in 1996", JKorean Soc Virol, 28, pp.377~382 (1998)
  49. 송진원, "1997~1998년 한국에서 발생한 열성 질환에 대한 혈청역학적 연구", Journal of Bacteriology and Virology, 32(3), pp.263~267 (2002), 대한미생물학회
  50. Lau CL, "Climate change, flooding,urbanisation and leptospirosis: fuelling the fire", TransR Soc Trop Med Hyg, 104, pp.631~638 (2010)
  51. Kupek E, "The relationship between rainfall and human leptospirosisin Florianopolis, Brazil, 1991-1996", Braz J InfectDis, 4, pp.131~134 (2000)
  52. Desvars A, "Seasonality of human leptospirosis in ReunionIsland (Indian Ocean) and its association with meteorologicaldata", PLoS One, 6, pp.e20377~ (2011)
  53. Robertson C, "Spatial epidemiologyof suspected clinical leptospirosis in Sri Lanka", EpidemiolInfect, 140, pp.731~743 (2012)
  54. 김시헌, "국내 기후변화 관련 감염병과 기상요인간의 상관성", 예방의학회지, 43(5), pp.436~444 (2010), 대한예방의학회
  55. 임은경, "PCR에 의한 들쥐의 렙토스피라균 감염 조사", Journal of Bacteriology and Virology, 33(3), pp.177~181 (2003), 대한미생물학회
  56. O'Guinn ML, "Serologicalsurveillance of scrub typhus, murine typhus, andleptospirosis in small mammals captured at firing points10 and 60, Gyeonggi province, Republic of Korea, 2001-2005", Vector Borne Zoonotic Dis, 10, pp.125~133 (2010)
  57. Sames WJ, "SerologicalSerological surveillance of scrub typhus, murinetyphus, and leptospirosis in small mammals captured atTwin Bridges Training Area, Gyeonggi Province, Republicof Korea, 2005-2007", Mil Med, 175, pp.48~54 (2010)
  58. Kim HC, "Seroepidemiological survey of rodentscollected at a U.S. military installation, Yongsan Garrison,Seoul, Republic of Korea", Mil Med, 172, pp.759~764 (2007)
  59. Jung BY, "Seroprevalence of leptospirosis in Koreanmunicipal zoo animals", J Vet Med Sci, 69, pp.861~863 (2007)
  60. Jung BY, "Seroprevalence of Leptospiraspp. in clinically healthy racing horses in Korea", J Vet MedSci, 72, pp.197~201 (2010)
  61. Ryu E, "The leptospiral agglutinin of Korean dogsand wild rats by employing filter paper and rapid microsocpicagglutination test. Takagi I", J Chosen Med, 28, pp.109~ (1920)

관련 논문AI추천

Leptospirosis in the Republic of Korea: Historical Perspectives, Current Status and Future Challenges김민자대한감염학회 · Infection and Chemotherapy2013 · 제45권 제3호Historical Review of Leptospirosis in the Korea (1945 – 2015)김민자대한감염학회 · Infection and Chemotherapy2019 · 제51권 제3호렙토스피라병에서 폐침범의 임상적 관점김민자대한내과학회 · 대한내과학회지2009 · 제77권 제4호Absence of anti-Leptospira antibodies in stray dogs suggests alternative reservoirs: 2020~2021 study in SeoulBok Kyung Ku, Changseek Ro, Hyera Kim, Jae-Won Byun, KiChan Lee, Kyoungsuk Kang, Myounghee Lee, Yeonsu Oh, Zoya Afzal한국동물위생학회 · 한국동물위생학회지2024 · 제47권 제4호Epidemiological Characteristics of Rodents and Chiggers with Orientia Tsutsugamushi in the Republic of Korea박정욱, 서진종, 유대성, 이기성, 이재일, 정재근대한기생충학ㆍ열대의학회 · Parasites, Hosts and Diseases2020 · 제58권 제5호Seroepidemiological Survey of Zoonotic Diseases in Small Mammals with PCR Detection of Orientia tsutsugamushi in Chiggers, Gwangju, KoreaDong Min Kim, Dong-Ryong Ha, Eun Sun Kim, Hye Jung Park, Hyun Jae Song, Jae Il Lee, Jae Keun Chung, Jah Pyus, Jung Wook Park, Jung Yoon Lee, So Hyang Jung, Sun Hee Kim, Sun Ju Cho, Yi Deun Ha대한기생충학ㆍ열대의학회 · Parasites, Hosts and Diseases2016 · 제54권 제3호

이 간행물의 다른 논문 (15건)

Genomic Basis for Methicillin Resistance in Staphylococcus aureusTomomi Hishinuma, Miki Matsuo, Kyoko Kuwahara-Arai, Tadashi Baba, Keiichi Hiramatsu, Teruyo Ito, Sae Tsubakishita, Takashi Sasaki, Fumihiko Takeuchi, Yuh Morimoto, Yuki Katayamapp. 117-136The Changing Epidemiology of Childhood Pneumococcal Disease in Korea최영준, 이환종, 최은화pp. 145-148Fluad®-MF59®-Adjuvanted Influenza Vaccine in Older Adults김진은, Theodore F. Tsaipp. 159-174Clinical and Microbiologic Characteristics of Clostridium difficile Infection Caused by Binary Toxin Producing Strain in Korea강정옥, 배현주, 서미란, 김지은, 최태열pp. 175-183The Long and Short Incubation Periods of Plasmodium vivax Malaria in Korea: The Characteristics and Relating Factors연성기, 장재연, 김시헌, 곽진, 조수남, 김선자pp. 184-193
원문 보기