본문 바로가기
KERD
논문KCI 등재

Historical Review of Leptospirosis in the Korea (1945 – 2015)

김민자
대한감염학회 (The Korean Society Of Infectious Diseases)|2019.09|Infection and Chemotherapy|제51권 제3호|pp. 315-329|DOI https://doi.org/10.3947/ic.2019.51.3.315

0

조회

0

다운로드

0

인용

0

참고문헌

키워드

KoreaCommunicable diseasesHistoryLeptospirosisLeptospira
주제분류내과학

초록

Leptospirosis is a widespread worldwide zoonosis. Human leptospirosis was first identified in the Korea in 1984 as the cause of “epidemic pulmonary hemorrhagic fever of unknown etiology” that occurred sporadically or in outbreaks. The major outbreaks, leading to some deaths, mainly involved rice field farmers who worked in wet and muddy rice paddies following floods or heavy rainfalls. Leptospirosis was designated a nationally notifiable disease in 1987. The Korean government introduced a supplementary immunization program to control the disease from 1988 to 1997, which provided people at risk in endemic areas with the inactivated vaccine prepared from a local strain Leptospira interrogans serovar Lai. In addition, the continuous promotion of education and awareness in the media played a role in improving personal hygiene management. Since then, the reported incidence of leptospirosis has been low. Leptospirosis is currently considered in the differential diagnosis of acute febrile illnesses occurring in fall. This study historically reviews clinical and epidemiological publications, scientific reports, and public health policies for recognition, identification, and infection control of human leptospirosis in the Korea.

Abstract

Leptospirosis is a widespread worldwide zoonosis. Human leptospirosis was first identified in the Korea in 1984 as the cause of “epidemic pulmonary hemorrhagic fever of unknown etiology” that occurred sporadically or in outbreaks. The major outbreaks, leading to some deaths, mainly involved rice field farmers who worked in wet and muddy rice paddies following floods or heavy rainfalls. Leptospirosis was designated a nationally notifiable disease in 1987. The Korean government introduced a supplementary immunization program to control the disease from 1988 to 1997, which provided people at risk in endemic areas with the inactivated vaccine prepared from a local strain Leptospira interrogans serovar Lai. In addition, the continuous promotion of education and awareness in the media played a role in improving personal hygiene management. Since then, the reported incidence of leptospirosis has been low. Leptospirosis is currently considered in the differential diagnosis of acute febrile illnesses occurring in fall. This study historically reviews clinical and epidemiological publications, scientific reports, and public health policies for recognition, identification, and infection control of human leptospirosis in the Korea.

참고문헌 (73)

  1. Inada R, "The etiology, mode of infection, and specific therapy of Weil's disease (Spirochaetosis icterohemorrhagica)", J Exp Med, 23, pp.377~402 (1916)
  2. "Dtsch Arch Klin Med", 1886, 209~232
  3. Fain S, "Leptospira and leptospirosis", pp.1~19 (1994), CRC press
  4. Chun C, "An overview of acute infectious diseases in South Korea", pp.155~156 (1975), Newest Medical Publisher
  5. Chun CH, "Zoonotic contagious disease in Korea", Korean J Infect Dis, 7, pp.37~42 (1975)
  6. Kang SY, "Panel discussion : A pneumonitis-like disease epidemic during this autumn", J Korean Med Assoc, 18, pp.1095~1102 (1975)
  7. Park SC, "An epidemiological study on the epidemic pneumonitis, occurred in Ryeo Ju and I Cheon, central area of Korea, 1975", J Korean Med Assoc, 19, pp.263~268 (1976)
  8. Nam SD, "Epidemiological pattern of acute endemic respiratory diseases", J Korean Med Assoc, 19, pp.269~273 (1976)
  9. Kim KH, "Clinical pictures of the hemorrhagic pneumonia like disease which occurred epidemically in the central area of Korea in autumn, 1975", J Korean Med Assoc, 19, pp.274~286 (1976)
  10. Chae IS, "An epidemiological, clinical, and radiological study of the epidemic pneumonitis, occurred in the central area of Korea in autumn, 1975", J Korean Med Assoc, 19, pp.287~292 (1976)
  11. Bahk YW, "Radiologic manifestation of pneumonia-like disease occurred in the central area of Korea in autumn, 1975", J Korean Med Assoc, 19, pp.293~297 (1976)
  12. Kim KS, "On the radiologic findings", J Korean Med Assoc, 19, pp.298~302 (1976)
  13. Han WS, "Autopsy and postmortem needle biopsy findings of pneumonitis-like disease", J Korean Med Assoc, 19, pp.303~306 (1976)
  14. Moon GJ, "The gross and histopathological findings", J Korean Med Assoc, 19, pp.307~309 (1976)
  15. Ro YM, "Acute febrile hemorrhagic lung disease of unknown cause – A report of 20 cases in the epidemic of October through November in 1975", J Korean Med Assoc, 19, pp.315~323 (1976)
  16. Choe KH, "Epidemic pulmonary hemorrhagic fever: II. Retrospective study (1970-1974)", J Korean Med Assoc, 23, pp.145~150 (1980)
  17. Shim YH, "Epidemic pulmonary hemorrhagic fever: I. Epidemiological and clinical observation", J Korean Med Assoc, 23, pp.131~144 (1980)
  18. Kim JS, "An analytic epidemiological study to test the hypothesis, leptospirosis as the cause of epidemic pulmonary hemorrhagic fever in Korea", Korean J Epidemiol, 6, pp.8~15 (1984)
  19. Cho MK, "Bacteriological studies on leptospirosis in Korea(1984)", Korean J Epidemiol, 6, pp.16~26 (1984)
  20. Lee WY, "Leptospira interrogans"Korea"isolated from patients with epidemic pulmonary hemorrhagic fever", Korean J Epidemiol, 6, pp.36~46 (1984)
  21. Paik SB, "Isolation and identification of pathogen for pneumonitislike disease epidemic in South Korea", Korea National Institute of Health Annual Report, 13, pp.127~134 (1976)
  22. Kim MJ, "Infectious diseases occurring in autumn season in South Korea : Clinical and epidemiological characteristics of leptospirosis", J Korean Med Assoc, 37, pp.1408~1414 (1994)
  23. Choi BY, "The surveillance and management system of leptospirosis in a rural community of Korea, 1989 and 1990", Korean J Epidemiol, 15, pp.74~84 (1993)
  24. Lee HW, "Seroepidemiologic studies of acute hemorrhagic diseases in Korea from 1985 to 1987(hemorrhagic fever with renal syndrome, leptospirosis and scrub typhus)", J Korean Med Assoc, 31, pp.581~593 (1988)
  25. Studies on the Epidemiology of Leptospirosis in Korea (I), "National Institute of Health", 109~127 (1986)
  26. Cho MK, "Characterization of Leptospira interrogans isolated in Korea and seroepidemiological study on leptospirosis(1984-1987)", J Korean Med Assoc, 31, pp.612~622 (1988)
  27. Cho MK, "Serological studies on leptospirosis in Kangwondo area(1985)", J Korean Soc Microbiol, 21, pp.205~210 (1986)
  28. Chang WH, "Seroepidemiological study of leptospirosis in Korea, 1987", Korean J Infect Dis, 20, pp.179~186 (1988)
  29. Chang WH, "Seroepidemiological survey of leptospirosis in Korea, 1988 and 1989", J Korean Soc Microbiol, 25, pp.341~346 (1990)
  30. Kim YW, "Patterns of acute febrile illness (murine typhus, scrub typhus, leptospirosis and hemorrhagic fever with renal syndrome) from 1986 to 1990 in Korea", J Korean Soc Microbiol, 26, pp.431~441 (1991)
  31. Chang WH, "Seroepidemiological survey of the leptospirosis in Korea, 1986-1991", J Korean Soc Microbiol, 28, pp.13~22 (1993)
  32. Dikken H, "Methods in Microbiology", pp.259~309 (1978), Academic Press
  33. Kobayashi Y, "Characterization of monoclonal antibodies against etiological agents of Weil's disease", Microbiol Immunol, 28, pp.359~370 (1984)
  34. Marshall RB, "Identification of leptospira serovars by restriction-endonuclease analysis", J Med Microbiol, 14, pp.163~166 (1981)
  35. Oh HB, "Serological analysis of Leptospira interrogans isolated in Korea by cross-agglutinin adsorption method(1985)", J Korean Soc Microbiol, 21, pp.337~343 (1986)
  36. Kim MJ, "Serovar identification of Korean leptospiral strains with monoclonal antibodies", Korean J Med, 32, pp.571~579 (1987)
  37. Kim MJ, "Clinical features of serologically proven leptospirosis in Korea and changes in leptospiral agglutinin titer", Korean J Med, 32, pp.188~197 (1987)
  38. Chen T, "Development and present status of leptospiral vaccine and technology of vaccine production in China", Jpn J Bacteriol, 40, pp.755~762 (1985)
  39. Chang WH, "Restriction endonuclease DNA analysis of leptospiral field isolates from Korea", J Korean Soc Microbiol, 22, pp.463~471 (1987)
  40. Chang WH, "Serological analysis of Leptospira interrogans isolated in Korea by monoclonal antibodies", J Korean Soc Microbiol, 23, pp.277~292 (1988)
  41. Chang WH, "Restriction endonuclease DNA analysis and monoclonal antibody analysis of Leptospira interrogans isolated in Korea", J Korean Soc Microbiol, 24, pp.71~79 (1989)
  42. Cho MK, "Serovar Determination of Leptospira interrogans isolated in Korea by cross-agglutinin absorption method(1984-1987)", J Korean Soc Microbiol, 23, pp.169~177 (1988)
  43. Cho MK, "Serological analysis of Leptospira Interrogans in Korea using monoclonal antibodies and cross-agglutinin absorption test", J Korean Soc Microbiol, 24, pp.539~548 (1989)
  44. Oh HB, "Identification of new serovar yeonchon and hongchon belonging to Leptospira interrogans icterohemorragiae seogroup", J Korean Soc Microbiol, 26, pp.253~262 (1991)
  45. Sekiguchi I, "Leptospirosis on Kyonsang-buck-do", Saikingaku Zasshi, 553, pp.164~172 (1942)
  46. Cha Y, "Study on leptospirosis, I. Seroepidemiological investigation of cattle", Domestic Animal Farming Hygiene Reports, 6, pp.53~59 (1959)
  47. Studies on the Epidemiology of Leptospirosis in Korea (II), "National Institute of Health", 110~147 (1987)
  48. Faine S, "Guidelines for the control of leptospirosis, 67", pp.21~23 (1982), WHO
  49. Kim JS, "An epidemiological study on identification of cause for epidemic pulmonary hemorrhagic fever", J Korean Med Assoc, 28, pp.77~78 (1985)
  50. Chun HJ, "Clinical, roentgenological and pathological evaluation of hemorrhagic pulmonary fever", J Korean Military Med Assoc, 16, pp.154~166 (1985)
  51. Choi BY, "An epidemiologic study on the leptospiral infection in the period of an anticipated epidemic-for soldiers stationed in a rural area", Korean J Epidemiol, 14, pp.91~101 (1992)
  52. 이훈재, "벼베기 대민지원 장병들의 렙토스피라증 발생에 관한 혈청역학적 연구", 석사, 역학, pp.1999
  53. Kim MJ, "Leptospirosis in Korea: clinical and epidemiologic study", Proceedings of Leptospirosis Research Conference 1990, Japanese Leptospirosis Research Society, pp.88~103 (1991), Hokusen-sha pub
  54. Chang WG, "An epidemiological and clinical study of leptospirosis acquired by twelves combat policemen in september, 2000", Korean J Med, 61, pp.553~561 (2001)
  55. Choi KW, "Clinical characteristics of epidemic pulmonary hemorrhagic fever summarized from papers published", Korean J Epidemiol, 6, pp.3~7 (1984)
  56. Kim MJ, "Clinical characteristics of leptospirosis in Korea", J Korean Med Assoc, 31, pp.623~627 (1988)
  57. Silva JJ, "Clinicopathological and immunohistochemical features of the severe pulmonary form of leptospirosis", Rev Soc Bras Med Trop, 35, pp.395~399 (2002)
  58. Seijo A, "Lethal leptospiral pulmonary hemorrhage: an emerging disease in Buenos Aires", Argentina. Emerg Infect Dis, 8, pp.1004~1005 (2002)[DOI]
  59. Yersin C, "Human leptospirosis in the Seychelles(Indian Ocean) : a population-based study", Am J Trop Med Hyg, 59, pp.933~940 (1998)
  60. Dolhnikoff M, "Pathology and pathophysiology of pulmonary manifestations in leptospirosis", Braz J Infect Dis, 11, pp.142~148 (2007)
  61. 강승지, "최근 7년간 일개 대학병원에서 경험한 렙토스피라병의 임상적 고찰", 대한내과학회지, 77(4), pp.453~460 (2009), 대한내과학회
  62. 김민자, "렙토스피라병에서 폐침범의 임상적 관점", 대한내과학회지, 77(4), pp.450~452 (2009), 대한내과학회
  63. Chang W, "Microbiological and pathological features of experimentally induced leptospirosis in guinea pigs", J Korean Soc Microbiol, 21, pp.211~226 (1986)
  64. Woo JH, "An experimental study of the pathogenesis of pulmonary hemorrhagic lesions in leptospirosis", Korean J Med, 38, pp.644~655 (1990)
  65. Lee SH, "Identification and partial characterization of a novel hemolysin from Leptospira interrogans serovar lai", Gene, 254, pp.19~28 (2000)
  66. Lee SH, "Cytotoxic activities of Leptospira interrogans hemolysin SphH as a poreforming protein on mammalian cells", Infect Immun, 70, pp.315~322 (2002)
  67. Lee JS, "Clinical features of the case identified as leptospirosis", Korean J Epidemiol, 6, pp.47~51 (1984)
  68. Lee JS, "Clinical studies on leptospirosis in Korea", J Korean Med Assoc, 29, pp.537~547 (1986)
  69. Kim SY, "The leptospirosis associated with fever and rash", Korean J Infect Dis, 18, pp.19~23 (1986)
  70. Kim SJ, "A clinical study of leptospirosis in Chung Nam area", Korean J Infect Dis, 19, pp.33~37 (1987)
  71. Kim WY, "The 16 cases of leptospirosis in Chuncheon area", Korean J Med, 30, pp.745~750 (1986)
  72. Lee YC, "The 13 cases of confirmed leptospirosis in Chun Cheon area, by the culture and isolation of leptospira, in 1986", Korean J Med, 32, pp.580~587 (1987)
  73. Park SK, "Leptospirosis in Chonbuk Province of Korea in 1987 : a study of 93 patients", Am J Trop Med Hyg, 41, pp.345~351 (1989)

관련 논문AI추천

Leptospirosis in the Republic of Korea: Historical Perspectives, Current Status and Future Challenges김민자대한감염학회 · Infection and Chemotherapy2013 · 제45권 제3호Leptospirosis in the Republic of Korea: Historical Perspectives, Current Status and Future Challenges김민자대한감염학회 · Infection and Chemotherapy2013 · 제45권 제2호렙토스피라병에서 폐침범의 임상적 관점김민자대한내과학회 · 대한내과학회지2009 · 제77권 제4호객혈 없이 성인형 호흡 곤란 증후군을 동반한 렙토스피라증고경태, 나동집, 박상민, 박상훈, 윤희정, 이성훈, 이양덕, 임준철, 조용선, 한민수, 한상훈, 홍영철대한감염학회 · Infection and Chemotherapy2006 · 제38권 제6호Absence of anti-Leptospira antibodies in stray dogs suggests alternative reservoirs: 2020~2021 study in SeoulBok Kyung Ku, Changseek Ro, Hyera Kim, Jae-Won Byun, KiChan Lee, Kyoungsuk Kang, Myounghee Lee, Yeonsu Oh, Zoya Afzal한국동물위생학회 · 한국동물위생학회지2024 · 제47권 제4호경주시 일부 농업인의 가을철 발열성 질환 실태조사 - 쯔쯔가무시증, 렙토스피라증, 신증후군출혈열-이관, 김동섭, 박지혁, 유석주, 딜라람 아자리아한국농촌의학.지역보건학회 · 농촌의학.지역보건2019 · 제44권 제1호

이 간행물의 다른 논문 (9건)

Treatment of Extrapulmonary Nontuberculous Mycobacterial Diseases위유미pp. 245-255Investigation of a Mumps Outbreak in a Dental Clinic at a University Hospital이순옥, 김계형, 이종윤, 이정은, 강진숙pp. 256-262Prognostic Value of Serum Procalcitonin level for the Diagnosis of Bacterial Infections in Critically-ill PatientsPreecha Montakantikul, Apichot So-Ngern, Pakwan Bunupuradah, Sombat Leelasupasri, Suvatna Chulavatnatol, Chalermsri Pummangurapp. 263-273Clinical Characteristics and Outcomes of Patients with Culture-Negative Pyogenic Spondylitis according to Empiric Glycopeptide Use김영훈, 김진성, 류경식, 전윤희, 허정우, 하기용, 이용대, 김윤정pp. 274-283Antibiotic Treatment of Vertebral Osteomyelitis caused by Methicillin-Susceptible Staphylococcus aureus: A Focus on the Use of Oral β-lactams추은주, 박성연, 류성열, 정진원, 김시현, 김백남, 곽이경, 오원섭, Chi Sook Moonpp. 284-294
원문 보기