Absence of anti-Leptospira antibodies in stray dogs suggests alternative reservoirs: 2020~2021 study in Seoul
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Leptospirosis, a globally prevalent zoonotic disease, is primarily caused by Leptospira interrogans and poses significant public health challenges, especially in tropical regions. This study aimed to investigate the prevalence of leptospiral infections among stray dogs in Seoul, Korea, using the Microscopic Agglutination Test (MAT) for 15 standard leptospiral strains during 2020∼2021. Despite the historical context of canine leptospirosis and its role in zoonotic transmission, all 330 stray dogs tested in this survey were found negative for Leptospira antibodies. These findings suggest that stray dogs are unlikely to be a reservoir for Leptospira and that unknown alternative reservoirs such as rodents and other animals may exist, but this study found no evidence to support this. The study underscores the need for continuous surveillance and management of stray dogs to prevent zoonotic diseases, reflecting on both past findings and the negative results of current tests. Further research is necessary to validate these findings across different environmental conditions and to improve diagnostic methods beyond the standard MAT due to its limitations in handling and sensitivity.
Abstract
Leptospirosis, a globally prevalent zoonotic disease, is primarily caused by Leptospira interrogans and poses significant public health challenges, especially in tropical regions. This study aimed to investigate the prevalence of leptospiral infections among stray dogs in Seoul, Korea, using the Microscopic Agglutination Test (MAT) for 15 standard leptospiral strains during 2020∼2021. Despite the historical context of canine leptospirosis and its role in zoonotic transmission, all 330 stray dogs tested in this survey were found negative for Leptospira antibodies. These findings suggest that stray dogs are unlikely to be a reservoir for Leptospira and that unknown alternative reservoirs such as rodents and other animals may exist, but this study found no evidence to support this. The study underscores the need for continuous surveillance and management of stray dogs to prevent zoonotic diseases, reflecting on both past findings and the negative results of current tests. Further research is necessary to validate these findings across different environmental conditions and to improve diagnostic methods beyond the standard MAT due to its limitations in handling and sensitivity.
참고문헌 (14)
- Goh SH, "Shedding and genetic diversity of Leptospira spp. from urban stray dogs in Klang Valley, Malaysia", Top Comp Anim Med, 45, pp.100562~ (2021)
- Helman SK, "Pathogenic Leptospira are widespread in the urban wildlife of southern California", Sci Rep, 13, pp.14368~ (2023)
- "Infectious Disease Portal" (2024)[URL]
- Joshi YP, "The influence of climatic factors on the development of hemorrhagic fever with renal syndrome and leptospirosis during the peak season in Korea : an ecologic study", BMC Infect Dis, 17, pp.1~11 (2017)
- Kim MJ, "Leptospirosis in the Republic of Korea : historical perspectives, current status and future challenges", Infect Chemother, 45, pp.137~ (2013)
- "Korea Disease Control and Prevention Agency Infectious Disease Center" (2024)[URL]
- Levett PN, "Leptospirosis", Clin Microbiol Rev, 14, pp.296~326 (2001)
- Ministry of Agriculture, Food and Rural Affairs, "Handbook of Animal Infectious Diseases" (2003), National Veterinary Research and Quarantine Service
- Miotto BA, "Prospective study of canine leptospirosis in shelter and stray dog populations : Identification of chronic carriers and different Leptospira species infecting dogs", PLoS One, 13, pp.e0200384~ (2018)
- Perez-Garcia J, "Canine leptospirosis in a northwestern region of Colombia : serological, molecular and epidemiological factors", Pathogens, 11, pp.1040~ (2022)
- Rentko VT, "Canine leptospirosis : a retrospective study of 17 cases", J Vet Intern Med, 6, pp.235~244 (1992)
- Smith S, "A simple score to predict severe leptospirosis", PLOS Negl Trop Dis, 13(2), pp.e0007205~ (2019)
- Thibeaux R, "The zoonotic pathogen Leptospira interrogans mitigates environmental stress through cyclic-di-GMPcontrolled biofilm production", NPJ Biofilms Microbiomes, 6, pp.24~ (2020)
- Zakharova OI, "Environmental risk of leptospirosis in animals : the case of the Republic of Sakha(Yakutia), Russian Federation", Pathogens, 9, pp.504~ (2020)