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The Changing Epidemiology of Childhood Pneumococcal Disease in Korea

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초록

The wide use of antimicrobial agents and 7-valent pneumococcal conjugate vaccine (PCV7) has led to major changes in the epidemiology of childhood pneumococcal diseases. In Korea, data on the population-based incidence of childhood invasive pneumococcal diseases (IPD) are not available; however, institution-based surveillance data suggest a substantial burden of childhood IPD. Following the introduction of the PCV7 in Korea in 2003, the proportion of IPD caused by vaccine-type pneumococci has decreased, while non-PCV7 serotypes, especially serotypes 19A and 6A, whose proportions had been increasing before the introduction of the vaccine, became predominant among childhood IPD isolates. This article reviews the overall impact of PCV7 utilization and summarizes the results obtained so far. Continuous monitoring and gathering of scientific evidence for the epidemiological transition of pneumococcal carriage and IPD will be important for the management of pneumococcal infections in Korea.

Abstract

The wide use of antimicrobial agents and 7-valent pneumococcal conjugate vaccine (PCV7) has led to major changes in the epidemiology of childhood pneumococcal diseases. In Korea, data on the population-based incidence of childhood invasive pneumococcal diseases (IPD) are not available; however, institution-based surveillance data suggest a substantial burden of childhood IPD. Following the introduction of the PCV7 in Korea in 2003, the proportion of IPD caused by vaccine-type pneumococci has decreased, while non-PCV7 serotypes, especially serotypes 19A and 6A, whose proportions had been increasing before the introduction of the vaccine, became predominant among childhood IPD isolates. This article reviews the overall impact of PCV7 utilization and summarizes the results obtained so far. Continuous monitoring and gathering of scientific evidence for the epidemiological transition of pneumococcal carriage and IPD will be important for the management of pneumococcal infections in Korea.

참고문헌 (74)

  1. Robinson KA, "Active Bacterial CoreSurveillance (ABCs)", Emerging Infections Program Network.Epidemiology of invasive Streptococcus pneumoniaeinfections in the United States, 1995-1998: Opportunitiesfor prevention in the conjugate vaccine era, 2001, pp.285, 1729~1735
  2. O'Brien KL, "Hiband Pneumococcal Global Burden of Disease Study Team.Burden of disease caused by Streptococcus pneumoniaein children younger than 5 years: global estimates", Lancet, 374, pp.893~902 (2009)
  3. Bravo LC, "Asian Strategic Alliance for Pneumococcal DiseasePrevention (ASAP) Working Group. Overview of thedisease burden of invasive pneumococcal disease in Asia", Vaccine, 27, pp.7282~7291 (2009)
  4. Zangwill KM, "Epidemiology of invasive pneumococcaldisease in southern California: implications forthe design and conduct of a pneumococcal conjugate vaccineefficacy trial", J Infect Dis, 174, pp.752~759 (1996)
  5. Hsu HE, "Effect of pneumococcal conjugate vaccine on pneumococcalmeningitis", N Engl J Med, 360, pp.244~256 (2009)
  6. Kaplan SL, "Decreaseof invasive pneumococcal infections in childrenamong 8 children’s hospitals in the United States after theintroduction of the 7-valent pneumococcal conjugate vaccine", Pediatrics, 113, pp.443~449 (2004)
  7. Centers for Disease Control and Prevention (CDC), "Directand indirect effects of routine vaccination of children with7-valent pneumococcal conjugate vaccine on incidence ofinvasive pneumococcal disease--United States, 1998-2003", MMWR Morb Mortal Wkly Rep, 54, pp.893~897 (2005)
  8. Pilishvili T, "Active BacterialCore Surveillance", Emerging Infections Program Network.Sustained reductions in invasive pneumococcal disease inthe era of conjugate vaccine, 2010, pp.201, 32~41
  9. Ladhani SN, "Impact of the 7-valent pneumococcal conjugatevaccine on invasive pneumococcal disease in infantsyounger than 90 days in England and wales", Clin InfectDis, 56, pp.633~640 (2013)
  10. Ben-Shimol S, "Israeli Bacteremia andMeningitis Active Surveillance Group. Rapid reduction ininvasive pneumococcal disease after introduction of PCV7into the National Immunization Plan in Israel", Vaccine, 30, pp.6600~6607 (2012)
  11. Liao WH, "Impact of pneumococcal vaccineson invasive pneumococcal disease in Taiwan", Eur J ClinMicrobiol Infect Dis, 29, pp.489~492 (2010)
  12. Nam SG, "Etiology of invasive bacterial infectionsin apparently healthy children", Korean J Infect Dis, 30, pp.227~234 (1998)
  13. 이준호, "Etiology of Invasive Bacterial Infections in Immunocompetent Children in Korea (1996-2005): A Retrospective Multicenter Study", Journal of Korean Medical Science, 26(2), pp.174~183 (2011), 대한의학회
  14. Cho EY, "Causative pathogens amongchildhood bacterial invasive infection in Korea; a multicenterstudy, 2006-2010", Annual meeting of the KoreanSociety of Pediatric Infectious Diseases, 10, pp.17~ (2012)
  15. Kim KH, "The causative organisms of bacterial meningitis in Koreanchildren, 1986-1995", J Korean Med Sci, 13, pp.60~64 (1998)
  16. 조혜경, "The Causative Organisms of Bacterial Meningitis in Korean Children in 1996-2005", Journal of Korean Medical Science, 25(6), pp.895~899 (2010), 대한의학회
  17. Kim JS, "Incidence of Haemophilus influenzaetype b and other invasive diseases in South Koreanchildren", Vaccine, 22, pp.3952~3962 (2004)
  18. Moon JW, "A clinical observationon empema in children", J Korean Pediatr Soc, 21, pp.1147~1151 (1978)
  19. Yang DK, "The clinical observations ofempyema thoracis in childhood", J Korean Pediatr Soc, 7, pp.543~549 (1980)
  20. Kim SH, "A clinical observationson pyothorax in children", J Korean Pediatr Soc, 26, pp.667~674 (1983)
  21. 염혜영, "소아 농흉 원인균에 대한 다기관 연구(1999. 9-2004. 8)", Korean Journal of Pediatrics, 50(1), pp.33~39 (2007), 대한소아과학회
  22. Lee JH, "Diagnosis of pneumococcalempyema using immunochromatographic teston pleural fluid and serotype distribution in Korean children", Diagn Microbiol Infect Dis, 72, pp.119~124 (2012)
  23. Hansman D, "A resistant pneumococcus", Lancet, 2, pp.264~265 (1967)
  24. Song JH, "High prevalence of antimicrobialresistance among clinical Streptococcus pneumoniaeisolates in Asia (an ANSORP study)", AntimicrobAgents Chemother, 48, pp.2101~2107 (2004)
  25. Kim HO, "Organisms isolatedfrom blood at the Yonsei Medical Center, 1974-1983", KoreanJ Infect Dis, 17, pp.15~32 (1985)
  26. Hong SI, "Analysis ofantimicrobial susceptibility patterns of various microorganismsisolated from Seoul National University Hospital", Korean J Clin Pathol, 4, pp.149~162 (1984)
  27. Chong Y, "Capsular typesand antimicrobial resistance of Streptococcus pneumoniaeisolated in Korea", Eur J Clin Microbiol Infect Dis, 14, pp.528~531 (1995)
  28. Lee HJ, "Highincidence of resistance to multiple antimicrobials in clinicalisolates of Streptococcus pneumoniae from a universityhospital in Korea", Clin Infect Dis, 20, pp.826~835 (1995)
  29. Choi EH, "Clinical outcome of invasive infectionsby penicillin-resistant Streptococcus pneumoniae in Koreanchildren", Clin Infect Dis, 26, pp.1346~1354 (1998)
  30. Kim SN, "High incidenceof multidrug-resistant Streptococcus pneumoniaein South Korea", Microb Drug Resist, 2, pp.401~406 (1996)
  31. Chong Y, "Antimicrobial resistance of Streptococcus pneumoniaeand Enterococcus sp", J Korean Soc Chemother, 11, pp.48~55 (1993)
  32. Kim MN, "Penicillin resistance in Streptococcuspneumoniae", Korean J Clin Pathol, 11, pp.131~134 (1991)
  33. Park JY, "Serotypes and antimicrobial susceptibilities of Streptococcuspneumoniae isolated from the clinical specimen", Korean J Infect Dis, 26, pp.9~19 (1994)
  34. Song JH, "Spread of drug-resistantStreptococcus pneumoniae in Asian countries: AsianNetwork for Surveillance of Resistant Pathogens (ANSORP)Study", Clin Infect Dis, 28, pp.1206~1211 (1999)
  35. 최경민, "폐구균의 혈청형 분포와 항생제 감수성", Infection and Chemotherapy, 38(4), pp.179~185 (2006), 대한감염학회
  36. 김백남, "우리나라 항생제 사용 실태", Infection and Chemotherapy, 44(4), pp.250~262 (2012), 대한감염학회
  37. Byington CL, "Temporal trends of invasive disease due toStreptococcus pneumoniae among children in the intermountainwest: emergence of nonvaccine serogroups", Clin Infect Dis, 41, pp.21~29 (2005)
  38. Poehling KA, "Invasivepneumococcal disease among infants before andafter introduction of pneumococcal conjugate vaccine", JAMA, 295, pp.1668~1674 (2006)
  39. Black S, "Postlicensure surveillance forpneumococcal invasive disease after use of heptavalentpneumococcal conjugate vaccine in Northern CaliforniaKaiser Permanente", Pediatr Infect Dis J, 23, pp.485~489 (2004)
  40. Talbot TR, "Reduction in high rates of antibiotic-nonsusceptibleinvasive pneumococcal disease in tennessee after introductionof the pneumococcal conjugate vaccine", Clin InfectDis, 39, pp.641~648 (2004)
  41. Dagan R, "Impact of pneumococcal conjugate vaccine on infectionscaused by antibiotic-resistant Streptococcus pneumoniae", Clin Microbiol Infect, 15(3), pp.16~20 (2009)
  42. 조은영, "Changes in Serotype Distribution and Antibiotic Resistance of Nasopharyngeal Isolates of Streptococcus pneumoniae from Children in Korea, after Optional Use of the 7-Valent Conjugate Vaccine", Journal of Korean Medical Science, 27(7), pp.716~722 (2012), 대한의학회
  43. Dagan R, "Serotype replacement in perspective", Vaccine, 27(3), pp.C22~C24 (2009)
  44. Hicks LA, "Incidence of pneumococcaldisease due to non-pneumococcal conjugate vaccine(PCV7) serotypes in the United States during the eraof widespread PCV7 vaccination, 1998-2004", J Infect Dis, 196, pp.1346~1354 (2007)
  45. Kyaw MH, "Active Bacterial Core Surveillanceof the Emerging Infections Program Network. Effectof introduction of the pneumococcal conjugate vaccineon drug-resistant Streptococcus pneumoniae", N Engl JMed, 354, pp.1455~1463 (2006)
  46. Pallares R, "Resistance to penicillinand cephalosporin and mortality from severe pneumococcalpneumonia in Barcelona, Spain", N Engl J Med, 333, pp.474~480 (1995)
  47. Song JH, "Asian Network for Surveillance ofResistant Pathogens Study Group. Clinical outcomes ofpneumococcal pneumonia caused by antibiotic-resistantstrains in asian countries: a study by the Asian Networkfor Surveillance of Resistant Pathogens", Clin Infect Dis, 38, pp.1570~1578 (2004)
  48. Clinical and Laboratory Standards Institute, "Performance standards for antimicrobial susceptibility testing: 18th informationalsupplement CLSI document M100-S18", Wayne, ~ (2008)
  49. Jacobs MR, "Antimicrobial-resistant Streptococcus pneumoniae:trends and management", Expert Rev Anti InfectTher, 6, pp.619~635 (2008)
  50. Kim SH, "ANSORP Study Group. Changingtrends in antimicrobial resistance and serotypes ofStreptococcus pneumoniae isolates in Asian countries: anAsian Network for Surveillance of Resistant Pathogens(ANSORP) study", Antimicrob Agents Chemother, 56, pp.1418~1426 (2012)
  51. 서일혜, "개정된 Penicillin Breakpoints (CLSI M100-S18)에 따른 폐렴알균의 Penicillin 감수성률 변화", Annals of Clinical Microbiology, 13(2), pp.68~72 (2010), 대한임상미생물학회
  52. Hausdorff WP, "Geographical differencesin invasive pneumococcal disease rates and serotypefrequency in young children", Lancet, 357, pp.950~952 (2001)
  53. Hausdorff WP, "Whichpneumococcal serogroups cause the most invasive disease:implications for conjugate vaccine formulation anduse, part I", Clin Infect Dis, 30, pp.100~121 (2000)
  54. O'Brien KL, "Epidemiology ofinvasive Streptococcus pneumoniae among Navajo childrenin the era before use of conjugate pneumococcalvaccines, 1989-1996", Am J Epidemiol, 160, pp.270~278 (2004)
  55. Mohle-Boetani JC, "Carriage of Haemophilus influenzae type b in children afterwidespread vaccination with conjugate Haemophilus influenzaetype b vaccines", Pediatr Infect Dis J, 12, pp.589~593 (1993)
  56. Hammitt LL, "Indirect effect of conjugatevaccine on adult carriage of Streptococcus pneumoniae:an explanation of trends in invasive pneumococcaldisease", J Infect Dis, 193, pp.1487~1494 (2006)
  57. Millar EV, "Indirect effect of 7-valent pneumococcalconjugate vaccine on pneumococcal colonizationamong unvaccinated household members", Clin Infect Dis, 47, pp.989~996 (2008)
  58. Dagan R, "Reduction of nasopharyngeal carriage of pneumococciduring the second year of life by a heptavalent conjugatepneumococcal vaccine", J Infect Dis, 174, pp.1271~1278 (1996)
  59. Ghaffar F, "Effect of the 7-valent pneumococcalconjugate vaccine on nasopharyngeal colonizationby Streptococcus pneumoniae in the first 2 years oflife", Clin Infect Dis, 39, pp.930~938 (2004)
  60. Huang SS, , Pediatrics, 124, pp.e1~e11 (2009)
  61. Lee NY, "Carriage of antibiotic-resistantpneumococci among Asian children: a multinational surveillanceby the Asian Network for Surveillance of ResistantPathogens (ANSORP)", Clin Infect Dis, 32, pp.1463~1469 (2001)
  62. 김경효, "Nasopharyngeal Pneumococcal Carriage of Children Attending Day Care Centers in Korea: Comparison between Children Immunized with 7-valent Pneumococcal Conjugate Vaccine and Non-immunized", Journal of Korean Medical Science, 26(2), pp.184~190 (2011), 대한의학회
  63. Jong Gyun Ahn, "Enhanced detection and serotyping of Streptococcus pneumoniae using multiplex polymerase chain reaction", Korean Journal of Pediatrics, 55(11), pp.424~429 (2012), 대한소아과학회
  64. 이은경, "Nasopharyngeal Carriage Rate and Serotypes of Streptococcus pneumoniae and Antimicrobial Susceptibility in Healthy Korean Children Younger than 5 Years Old: Focus on Influence of Pneumococcal Conjugate Vaccination", Infection and Chemotherapy, 45(1), pp.76~84 (2013), 대한감염학회
  65. Centers for Disease Control and Prevention (CDC), "Invasivepneumococcal disease in children 5 years after conjugatevaccine introduction--eight states, 1998-2005", MMWR Morb Mortal Wkly Rep, 57, pp.144~148 (2008)
  66. Nuorti JP, "Centers for Disease Control andPrevention (CDC). Prevention of pneumococcal diseaseamong infants and children - use of 13-valent pneumococcalconjugate vaccine and 23-valent pneumococcalpolysaccharide vaccine - recommendations of the AdvisoryCommittee on Immunization Practices (ACIP)", MMWRRecomm Rep, 59, pp.1~18 (2010)
  67. Miller E, "Herd immunity and serotype replacement 4 years afterseven-valent pneumococcal conjugate vaccination inEngland and Wales: an observational cohort study", LancetInfect Dis, 11, pp.760~768 (2011)
  68. Albrich WC, "Changing characteristics of invasive pneumococcal diseasein Metropolitan Atlanta, Georgia, after introductionof a 7-valent pneumococcal conjugate vaccine", Clin InfectDis, 44, pp.1569~1576 (2007)
  69. Kellner JD, "Changing epidemiology of invasivepneumococcal disease in Canada, 1998-2007: updatefrom the Calgary-area Streptococcus pneumoniae research(CASPER) study", Clin Infect Dis, 49, pp.205~212 (2009)
  70. Hanquet G, "Pneumococcalserotypes in children in 4 European countries", Emerg InfectDis, 16, pp.1428~1439 (2010)
  71. Choi EH, "Streptococcus pneumoniae serotype 19A in children,South Korea", Emerg Infect Dis, 14, pp.275~281 (2008)
  72. Korea Centers for Disease Control and Prevention, "PublicHealth Weekly Report", PublicHealth Weekly Report, 3, pp.1~7 (2010)
  73. Cho EY, "Serotype and Antibiotic Resistance of Streptococcuspneumoniae Isolates from Invasive Disease in Childrenafter Optional Use of the 7-valent Conjugate Vaccine;A Multicenter Study, 2006-2010", Annual meeting of theKorean Society of Pediatric Infectious Diseases, 10, pp.14~ (2012)
  74. Choe YJ, "A comparativeestimation of coverage between National ImmunizationProgram (NIP) vaccines and non-NIP vaccines in the Republicof Korea", Annual meeting of the Korean Society ofPediatric Infectious Diseases, 10, pp.9~ (2012)

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