일부 여자대학생의 비만관련 인자 및 염증반응지표와 비만 호르몬과의 관계
Association of Obesity Linked Factors, and Inflammatory Factorswith Leptin Hormone in Female College Students
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연구배경 : 본 연구는 여자대학생들의 비만관련 인자, 염증반응지표, 그리고 렙틴 호르몬을 측정하여 관련성을 비교 분석함으로써 여자대학생의 건강증진을 위한 기초자료를 제공하는데 연구의 목적이 있다. 방 법 : 연구 대상자는 여자대학생을 무선표집으로 31명을 추출하였다. 혈액을 채취를 통하여 총콜레스테롤, 고밀도 지단백 콜레스테롤, 저밀도 지단백 콜레스테롤, C-반응단백, 인터루킨-6, 종양괴사인자-알파, 백혈구, 렙틴 호르몬을 분석하였고, 생체전기저항법으로 체지방률, 체지방량, 신장, 체중, 허리엉덩이둘레비율, 신체질량지수를 측정하였으며, 자동전자혈압계 (MD 730, Korea)를 이용하여 혈압을 측정하였다. 모든 자료의 통계처리는 렙틴 호르몬과 비만관련 인자, 염증반응지표와의 관련성을 피어슨 상관분석과 다중선형회귀분석, Dubin Watson Test를 통하여 분석하였다. 결 과 : 여자대학생의 렙틴 호르몬은 체중, 체지방률, 허리엉덩이둘레비율, 신체질량지수, 저밀도 지단백 콜레스테롤, 중성지방, C-반응단백과 유의한 상관관계가 있는 것으로 나타났다(p<.05). 그리고 체지방률, 고밀도 지단백 콜레스테롤은 렙틴 호르몬의 독립적인 예측인자로 나타났고(p<.05), 회귀식의 설명력은 76%로 나타났다. 결 론 : 렙틴 호르몬을 적절하게 조절하기 위해서는 체지방률, 허리엉덩이둘레비율, 신체질량지수, 저밀도 지단백 콜레스테롤, 중성지방, C-반응단백을 줄이는 것이 가장 효과적인 전략이라고 볼 수 있다.
Abstract
Background : Leptin is a protein hormone produced primarily by fat cells and plays a key role in regulating energy intake and expenditure including appetite and metabolism. But whether leptin is associated with obesity-linked factors and inflammatory factors across gender is not clear. We investigated the relationships between leptin and obesity-linked factors (weight, percent body fat, waist-hip-ratio, body mass index, blood pressure, total cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol, and triglyceride) and inflammatory factors (interleukin-6, C-reactive protein, tumor necrosis factor-α, and white blood cell) in 31 female college students. Methods : We measured total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), triglyceride (TG), interleukin--6 (IL-6), C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), white blood cell (WBC), and leptin hormone level using an enzymatic method. Percent body fat, fat mass, weight, height, waist-hip ratio (WHR), and body mass index (BMI) were analyzed using bioelectrical impedance (Biospace Co.), and blood pressure was measured by auto blood pressure machine (MD 730, Korea). Pearson product-moment correlation was used to investigate correlations between leptin and obesity-linked factors and inflammatory factors. Multiple linear regression was used to examine the associations between leptin and obesity-linked factors and inflammatory factors. Results : Leptin was significantly associated with weight (r=0.59, p=0.00), percent body fat (r=0.80, p=0.00), WHR (r=0.81, p=0.00), BMI (r=0.67, p=0.00), LDL-C (r=0.43, p=0.02), and CRP (r=0.40, p=0.03). In multiple linear regression analysis, percent body fat (t=6.39) and HDL-C (t=2.18) were shown to be significant predictors of the body's level of leptin. Percent body fat and HDL-C account for a variance in leptin levels of 76% in young female college students. Conclusions : We concluded that in order to properly adjust the level of leptin in female college students, a most effective strategy is to reduce percent body fat, WHR, BMI, LDL-C, TG, and CRP.
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