과체중 여자대학생의 혈중 지질농도 및 혈액성분과 염증지표와의 관계
Associations Between Blood Lipids, Blood Composition and Inflammatory Markers in Obese Female College Students
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연구배경: 본 연구는 비만 여자대학생의 혈중 지질농도 및 혈액성분과 염증지표를 측정하여 관련성을 비교 분석함으로써 여성의 건강증진과 비만예방을 위한 기초자료를 제공하는데 연구의 목적이 있다. 방법: 비만 여자대학생 60명을 목적추출 하였고, 대상자들의 신체적 특성을 측정하였다(mean age: 21.06±1.81 yr, percent body fat: 32.63±3.66%). 혈액채취를 통하여 총콜레스테롤, 고밀도지 지단백 콜레스테롤, 저밀도 지단백 콜레스테롤, 중성지방, 적혈구, 백혈구, 헤모글로빈, C-반응단백, 종양괴사인자-알파를 분석하였고, 생체전기저항법으로 체지방률, 체지방량, 신장, 체중을 측정하였다. 모든 자료의 통계처리는 종양괴사인자-알파와 혈중 지질농도, 혈액성분과의 관련성을 피어슨 상관분석과 다중선형회귀분석, Durbin Watson Test를 통하여 분석하였다. 결과: 비만 여자대학생의 종양괴사인자-알파는 고밀도 지단백콜레스테롤(r=-0.39, P<0.001)과 헤모글로빈(r=-0.32, P=0.01)과 유의한 상관관계를 보였다. 그리고 고밀도 지단백 콜레수테롤, 적혈구, 헤모글로빈은 종양괴사인자-알파의 독립적인 예측인자로 나타났고, 회귀식의 설명력은 41%로 나타났다. 결론: 종양괴사인자-알파의 적절한 농도를 유지하기 위해서는 고밀도 지단백 콜레스테롤, 적혈구, 헤모글로빈의 수치를 높이는 것이 효과적인 전략이라고 사료되며, 이와 관련하여 더 많은 대상자의 혈중 지질농도와 혈액성분, 염증지표 등을 고려한 다각적인 연구가 필요할 것이라고 제언한다.
Abstract
Background: The purpose of this study was to determine the associations between blood lipids and blood composition with inflammatory markers in obese female college students. Methods: Sixty obese college females (mean age: 21.06±1.81 yr, percent body fat: 32.63±3.66%) participated in this study. We measured the following blood parameters using an enzymatic method: total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), C-reactive protein (CRP), red blood cells (RBC), white blood cells (WBC), hemoglobin (Hb), and tumor necrosis factor-α(TNF-α). Percent body fat, fat mass, weight, height, and body mass index were analyzed using bio-electrical impedance (Biospace Co.). Pearson product-moment correlation and multiple linear regression were used to examine correlations between TNF-αand blood parameters Results: TNF-αwas significantly associated with HDL-C (r=-0.39, P<0.001) and Hb (r=-0.32, P=0.01). In the multiple linear regression analysis, HDL-C (t=-2.89), RBC (t=4.41), and Hb (t=-4.08) were significant predictors of TNF-α. HDL-C, RBC, and Hb accounted for variances in TNF-αin 41% of our obese female college subjects. Conclusions: To properly control the level of TNF-α in obese female college students, one of the effective strategy is to reduce HDL-C, RBC, and Hb.
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