한국인 성인남자의 저밀도 지단백 입자 크기 분포
Distribution of Low Density Lipoprotein Particle Size in Korean Adult Males
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초록
-연구배경 저밀도 지단백(Low density lipoprotein; LDL)은 다양한 크기 , 밀도, 조성을 가지는 입자로 혈중에 분포하며 이중 smal dense LDL은 저밀도 지단백 수용체 친화도가 낮고 proteoglycan 친화도가 높아 혈관 내벽을 잘 통과하며 산화에 취약한 것으로 알려져 있다. 이러한 생화학적 특징으로 인해 smal dense LDL은 죽상경화를 잘 일으키는 것으로 보고되어 있고 관상동맥질환 환자에서 증가를 보인다고 알려져 있다 . 하지만 저밀도 지단백 입자의 분포는 한국인에서 잘 알려져 있지 않다 . 본 연구에서는 LipoPrint LDL System을 이용하여 93명(50.1±7.5 세)의 한국인 성인 남자의 저밀도 지단백 입자 크기의 분포를 분석하였다. 방 법 공복 후 채혈한 혈청 검체를 이용하여 LipoPrint LDL System(Quantimetrix Corp., Redondo Beach, CA, USA)으로 저밀도 지단백 아형(subclass; subfraction)을 분석하였고 평균 저밀도 지단백 입자 크기에 따라 저밀도 지단백 표현형을 A형, I (intermediate)형, B형으로 분류하였다. 평균 저밀도 지단백 입자 크기가 268 Å 보다 큰 경우 A형, 265 Å에서 268 Å 사이인 경우 I형, 265 Å 보다 작은 경우 B형으로 분류하였다.결 과 한국인 성인 남자의 평균 저밀도 지단백 입자 크기는 265.1±4.7 Å이었으며 A형, I형, B형의 분포는 각각 30.1%, 30.1%, 39.8%이었다. 그리고 평균 저밀도 지단백 입자 크기는 중성지방 (Triglyceride; TG) 농도에 음의 상관관계 (r=-0.667, P<0.001)를 보였으며, 고밀도 지단백 콜레스테롤 (High density lipoprotein cholesterol; HDL-C) 농도와는 양의 상관관계 (r=0.479, P<0.001)를 보였지만, 총콜레스테롤(total cholesterol) 농도와는 상관관계를 보이지 않았다 .
Abstract
Background Among heterogeneous low density lipoprotein(LDL), small dense LDL particles can penetrate vascular intima easier and they are more susceptible to oxidation in vitro. These general characteristics are thought to make small dense LDL particles more atherogenic. And small dense LDL is known to be associated with coronary heart disease, but the distribution of mean LDL particle size is not well described in Koreans. Methods LDL subfraction profiles in 93 Korean adult males were estimated by the LipoPrint LDL System(Quantimetrix Corp., Redondo Beach, CA, USA). LDL subclass pattern were designated pattern A when mean LDL particle size was greater than 268Å, pattern B when it was smaller than 265Å, and pattern I when it was between 265Å and 268Å. Results The mean LDL particle size was 265.1±4.7Åin Korean adult males and the prevalence of pattern A, pattern B, and pattern I were 30.1%, 39.8%, and 30.1%, respectively. Mean LDL particle size showed negative correlation with serum concentrations of triglyceride(r=-0.667, P<0.001) and positive correlation with serum concentrations of HDL cholesterol(r=0.479, P<0.001) but had no significant correlation with the concentrations of cholesterol.
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