Martin’s Equation as the Most Suitable Method for Estimation of Low-Density Lipoprotein Cholesterol Levels in Korean Adults
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Background: Friedewald equation is the most widely used method for estimating low-density lipoprotein choles-terol (LDL-C) level. However, due to potential over- or underestimation, many studies have used a modified equa-tion. This study aimed to compare estimates by 4 different equations to directly measured LDL-C concentrations in order to propose the most appropriate method for LDL-C estimation in the Korean population.Methods: We studied data of 4,350 subjects that included total cholesterol, high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), and LDL-C concentrations that had been measured at one university hospital in Seoul. We investigated 4 equations: LDL-C by Friedewald’s original equation (LDL-CF) and its 3 modifications. Pearson correlation analysis was performed to compare these estimates to the direct measurement.Results: Pearson correlation analysis revealed a good correlation among all 4 estimated LDL-C values and the di-rectly measured LDL-C value. The Pearson coefficients were 0.951 for LDL-CF, 0.917 for LDL-C by Hatta equation (LDL-CH), 0.968 for LDL-C by Puavilai equation (LDL-CP), and 0.983 for LDL-C by Martin equation (LDL-CM). Mar-tin equation (LDL-CM) resulted in the best approximation (mean difference from the direct measurement, 5.5 mg/dL; mean percentage difference from the direct measurement, 5.1%) and the best agreement with the direct mea-surement (86.1%). LDL-CP resulted in the second-best approximation (mean difference, 7.0 mg/dL; mean percent-age difference, 6.2%; concordance, 82.5%). LDL-CM was found to be less influenced by TG and HDL-C levels than by LDL-CF.Conclusion: Estimates by Martin equation had the best agreement with direct LDL-C concentrations and both Martin and Puavilai equations were superior to Friedewald equation for estimating LDL-C concentrations in Kore-an adults.
Abstract
Background: Friedewald equation is the most widely used method for estimating low-density lipoprotein choles-terol (LDL-C) level. However, due to potential over- or underestimation, many studies have used a modified equa-tion. This study aimed to compare estimates by 4 different equations to directly measured LDL-C concentrations in order to propose the most appropriate method for LDL-C estimation in the Korean population.Methods: We studied data of 4,350 subjects that included total cholesterol, high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), and LDL-C concentrations that had been measured at one university hospital in Seoul. We investigated 4 equations: LDL-C by Friedewald’s original equation (LDL-CF) and its 3 modifications. Pearson correlation analysis was performed to compare these estimates to the direct measurement.Results: Pearson correlation analysis revealed a good correlation among all 4 estimated LDL-C values and the di-rectly measured LDL-C value. The Pearson coefficients were 0.951 for LDL-CF, 0.917 for LDL-C by Hatta equation (LDL-CH), 0.968 for LDL-C by Puavilai equation (LDL-CP), and 0.983 for LDL-C by Martin equation (LDL-CM). Mar-tin equation (LDL-CM) resulted in the best approximation (mean difference from the direct measurement, 5.5 mg/dL; mean percentage difference from the direct measurement, 5.1%) and the best agreement with the direct mea-surement (86.1%). LDL-CP resulted in the second-best approximation (mean difference, 7.0 mg/dL; mean percent-age difference, 6.2%; concordance, 82.5%). LDL-CM was found to be less influenced by TG and HDL-C levels than by LDL-CF.Conclusion: Estimates by Martin equation had the best agreement with direct LDL-C concentrations and both Martin and Puavilai equations were superior to Friedewald equation for estimating LDL-C concentrations in Kore-an adults.
참고문헌 (26)
- National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III), "Third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report", Circulation, 106, pp.3143~3421 (2002)
- Scandinavian Simvastatin Survival Study Group, "Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)", Lancet, 344, pp.1383~1389 (1994)
- Long-Term Intervention with Pravastatin in Ischaemic Disease(LIPID)Study Group, "Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels", N Engl J Med, 339, pp.1349~1357 (1998)
- Ridker PM, "Novel risk factors for systemic atherosclerosis:a comparison of C-reactive protein, fibrinogen, homocysteine, lipoprotein(a), and standard cholesterol screening as predictors of peripheral arterial disease", JAMA, 285, pp.2481~2485 (2001)
- Friedewald WT, "Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge", Clin Chem, 18, pp.499~502 (1972)
- Lindsey CC, "A clinical comparison of calculated versus direct measurement of low-density lipoprotein cholesterol level", Pharmacotherapy, 24, pp.167~172 (2004)
- Tighe DA, "Calculated low density lipoprotein cholesterol levels frequently underestimate directly measured low density lipoprotein cholesterol determinations in patients with serum triglyceride levels < or =4.52 mmol", l: an analysis comparing the LipiDirect magnetic LDL assay with the Friedewald calculation, 2006, pp.365, 236~242
- Rubies-Prat J, "Calculated low-density lipoprotein cholesterol should not be used for management of lipoprotein abnormalities in patients with diabetes mellitus", Diabetes Care, 16, pp.1081~1086 (1993)
- Hirany S, "A more valid measurement of low-density lipoprotein cholesterol in diabetic patients", Am J Med, 102, pp.48~53 (1997)
- Johnson R, "Use of the Friedewald formula to estimate LDL-cholesterol in patients with chronic renal failure on dialysis", Clin Chem, 43, pp.2183~2184 (1997)
- Matas C, "Limitations of the Friedewald formula for estimating low-density lipoprotein cholesterol in alcoholics with liver disease", Clin Chem, 40, pp.404~406 (1994)
- 황유철, "Optimal Range of Triglyceride Values to Estimate Serum Low Density Lipoprotein Cholesterol Concentration in Korean Adults: the Korea National Health and Nutrition Examination Survey, 2009", Journal of Korean Medical Science, 27(12), pp.1530~1535 (2012), 대한의학회
- 장성옥, "LDL-콜레스테롤의 Friedewald 계산값과 실측값 비교: 국민건강영양조사 2009-2010", 한국산학기술학회논문지, 16(8), pp.5492~5500 (2015), 한국산학기술학회[DOI]
- DeLong DM, "A comparison of methods for the estimation of plasma low-and very low-density lipoprotein cholesterol : the Lipid Research Clinics Prevalence Study", JAMA, 256, pp.2372~2377 (1986)
- Puavilai W, "The accuracy in using modified Friedewald equation to calculate LDL from non-fast triglyceride : a pilot study", J Med Assoc Thai, 92, pp.182~187 (2009)
- Martin SS, "Comparison of a novel method vs the Friedewald equation for estimating low-density lipoprotein cholesterol levels from the standard lipid profile", JAMA, 310, pp.2061~2068 (2013)
- Lee J, "Validation of the Martin method for estimating low-density lipoprotein cholesterol levels in Korean adults: findings from the Korea National Health and Nutrition Examination Survey, 2009-2011", PLoS One, 11, pp.e0148147~ (2016)
- Hatta Y, "Application of Friedewald’s LDL-cholesterol estimation formula to serum lipids in the Japanese population", Jpn Circ J, 50, pp.1191~1200 (1986)
- Planella T, "Calculation of LDL-cholesterol by using apolipoprotein B for classification of nonchylomicronemic dyslipemia", Clin Chem, 43, pp.808~815 (1997)
- Hattori Y, "Development of approximate formula for LDL-chol, LDL-apo B and LDL-chol", LDL-apo B as indices of hyperapobetalipoproteinemia and small dense LDL, 1998, pp.138, 289~299
- Wagner AM, "The effect of VLDL particles on the accuracy of a direct LDL-cholesterol method in type 2 diabetic patients", Clin Biochem, 36, pp.177~183 (2003)
- Saeidullah M, "A simple modification of Friedewald’s equation to calculate low-density lipoprotein cholesterol up to serum triglycerides concentration of 1000 mg", dl, 2009, pp.2, 62~65
- Chen Y, "A modified formula for calculating low-density lipoprotein cholesterol values", Lipids Health Dis, 9, pp.52~ (2010)
- Vujovic A, "Evaluation of different formulas for LDL-C calculation", Lipids Health Dis, 9, pp.27~ (2010)
- De Cordova CM, "A new accurate, simple formula for LDL-cholesterol estimation based on directly measured blood lipids from a large cohort", Ann Clin Biochem, 50(Pt 1), pp.13~19 (2013)
- Nigam PK, "Calculated low density lipoprotein-cholesterol : Friedewald’s equation versus other modified formulas : calculated LDL-cholesterol", Int J Life Sci Med Res, 4, pp.25~31 (2014)