남성에서 안면홍조 유무에 따른 주당 음주량과 이상지질혈증과의관계
Relationship among Alcohol Consumption, Facial Flushing Response and Dyslipidemia in Male
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연구배경: 주당 음주량과 이상지질혈증의 관련성에 음주후 안면홍조 유무에 따른 차이가 있는지 평가하였다. 방법: 연구 대상자는 2013년 1월부터 12월까지 대전 소재대학병원에서 검진한 1,443명의 한국 성인 남성이다(비음주군 261명, 홍조군 470명, 비홍조군 712명). 설문을 통해음주 후 안면홍조 유무, 일회 음주량, 주당 음주횟수, 흡연및 운동 여부, 과거 및 현병력을 파악하였고 주당 음주량은알코올 14 g을 표준 1잔으로 하여 4잔 단위로 범주화하였다. 로지스틱회귀분석으로 안면홍조 유무에 따른 주당 음주량과 이상지질혈증의 관련성을 분석하였다. 보정한 혼란변수는 연령, BMI, 흡연 및 운동 유무, 고혈압 및 당뇨병유무이다. 결과: 비음주군과 비교시 주당 음주량과 고LDL혈증의관련성은 안면홍조 유무에 따른 차이가 없었으며, 고콜레스테롤혈증도 마찬가지였다. 고중성지방혈증의 경우 홍조군은 유의한 차이가 없었으나, 비홍조군은 주당 음주량 4-8 잔(aOR 1.118, 95% CI 1.029-3.644), 16잔 이상(aOR 2.118, 95% CI 1.272-3.527) 범주에서 유의한 차이가 있었다. 저HDL혈증의 경우, 홍조군은 8-16잔(aOR 0.234, 95% CI 0.102-0.536), 16잔 이상(aOR 0.342, 95% CI 0.166-0.705)에서, 비홍조군은 모든 주당음주량 범주(4잔 미만: aOR 0.428, 95% CI 0.277-0.662; 4-8잔: aOR 0.409 95% CI 0.216-0.774; 8-16잔: aOR 0.285, 95% CI 0.152-0.536; 16잔 이상: aOR 0.343, 95% CI 0.207-0.568)에서 유의한 차이가 있었다. 결론: 본 연구 결과는 음주 후 안면홍조가 있는 자는 음주로 인한 중성지방과 HDL-C 상승이 적음을 시사한다
Abstract
Background:Facial flushing response to drinking is observed in East Asians with deficient activity of the variant aldehyde dehydrogenase 2 genotype. This study examined the role of flushing response in the relationship between alcohol consumption and dyslipidemia. Methods:This cross-sectional study included 1,443 Korean men, including 261 non-drinkers, 470 flushers and 712 non-flushers. Based on a questionnaire, weekly alcohol consumption was assessed and categorized into 4 groups. Dyslipidemia was defined by the National Cholesterol Education Program-Adult Treatment Panel III criteria. After adjusting for confounding factors, we evaluated the relationship between weekly alcoholic drinks and dyslipidemia in flushers and non-flushers by comparing with non-drinkers, using a multi-variable logistic regression analysis. Results:Non-flushers had a significant relationship between hypertriglyceridemia and alcohol consumption in two groups (4-8 drinks: adjusted odds ratio [aOR] 1.937, 95% confidence interval [CI] 1.029-3.644; ≥16 drinks: aOR 2.118, 95% CI 1.272-3.527) in contrast to flushers, who showed no significant relationship between hypertriglyceridemia and alcohol consumption. Non-flushers had a significant relationship to low serum high density lipoprotein (HDL) cholesterol levels in four groups (<4 drinks: aOR 0.428, 95% CI 0.277-0.662; 4-8 drinks: aOR 0.409, 95% CI 0.216-0.774; 8-16 drinks: aOR 0.285, 95% CI 0.152-0.536; ≥16 drinks: aOR 0.343, 95% CI 0.207-0.568), and flushers had a significant relationship in two groups (8-16 drinks: aOR 0.234, 95% CI 0.102-0.536; ≥16 drinks: aOR 0.342, 95% CI 0.166-0.705). Conclusions:Our results suggest that drinking alcohol increases the risk of hypertriglyceridemia in non-flushers and the risk of low HDL cholesterol flushers.
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