Influence of Facial Flushing on Pre- or Type 2 Diabetes Risk according to Alcohol Consumption in Korean Male
2
조회
0
다운로드
4
인용
0
참고문헌
키워드
초록
Background: This study aims to examine the association between alcohol consumption and the risk of pre- or type 2 diabetes mellitus (T2DM) by alcohol-induced flushing response in Korean male adults, particularly based on their body mass index (BMI). Methods: This study selected 1,030 (158 non-drinkers, 364 flushers, and 508 non-flushers) male adults who had medical checkups. A logistic regression analysis was used to compare the association between alcohol consumption and the risk of pre- or T2DM. Results: In both the normal-weight group (BMI <23 kg/m2) and the overweight group (BMI ≥23 kg/m2 and <25 kg/ m2), the flushers had a higher risk of pre- or T2DM (odds ratio, 95% confidence interval) when consuming more than 8 drinks of alcohol per week than the non-drinkers (normal-weight group: 3.43, 1.06–11.07; overweight group: 4.94, 1.56–15.67). But in the non-flushers among the normal-weight group and the overweight group, there was no significant difference compared to non-drinkers regarding the risk of pre- or T2DM. Obese flushers had a significantly higher risk of pre- or T2DM when consuming more than 4 drinks of alcohol per week than the non-drinkers (>4 and ≤8 drinks: 2.64, 1.10–6.36; >8 drinks: 2.42, 1.11–5.27). However, obese non-flushers had only a significant higher risk of pre- or T2DM when consuming more than 8 drinks of alcohol per week than the non-drinkers (2.72, 1.39–5.30) Conclusion: These results suggest that obese flushers have an increased risk of developing pre- or T2DM even with less alcohol consumption.
Abstract
Background: This study aims to examine the association between alcohol consumption and the risk of pre- or type 2 diabetes mellitus (T2DM) by alcohol-induced flushing response in Korean male adults, particularly based on their body mass index (BMI). Methods: This study selected 1,030 (158 non-drinkers, 364 flushers, and 508 non-flushers) male adults who had medical checkups. A logistic regression analysis was used to compare the association between alcohol consumption and the risk of pre- or T2DM. Results: In both the normal-weight group (BMI <23 kg/m2) and the overweight group (BMI ≥23 kg/m2 and <25 kg/ m2), the flushers had a higher risk of pre- or T2DM (odds ratio, 95% confidence interval) when consuming more than 8 drinks of alcohol per week than the non-drinkers (normal-weight group: 3.43, 1.06–11.07; overweight group: 4.94, 1.56–15.67). But in the non-flushers among the normal-weight group and the overweight group, there was no significant difference compared to non-drinkers regarding the risk of pre- or T2DM. Obese flushers had a significantly higher risk of pre- or T2DM when consuming more than 4 drinks of alcohol per week than the non-drinkers (>4 and ≤8 drinks: 2.64, 1.10–6.36; >8 drinks: 2.42, 1.11–5.27). However, obese non-flushers had only a significant higher risk of pre- or T2DM when consuming more than 8 drinks of alcohol per week than the non-drinkers (2.72, 1.39–5.30) Conclusion: These results suggest that obese flushers have an increased risk of developing pre- or T2DM even with less alcohol consumption.
참고문헌 (28)
- Wolff PH, "Ethnic differences in alcohol sensitivity", Science, 175, pp.449~450 (1972)
- Crabb DW, "Ethanol oxidizing enzymes : roles in alcohol metabolism and alcoholic liver disease", Prog Liver Dis, 13, pp.151~172 (1995)
- Agarwal DP, "Racial differences in biological sensitivity to ethanol : the role of alcohol dehydrogenase and aldehyde dehydrogenase isozymes", Alcohol Clin Exp Res, 5, pp.12~16 (1981)
- Jung JG, "Hypertension associated with alcohol consumption based on the facial flushing reaction to drinking", Alcohol Clin Exp Res, 38, pp.1020~1025 (2014)
- 김민영, "Relationship between Alcohol Consumption and Metabolic Syndrome according to Facial Flushing in Korean Males", Korean Journal of Family Medicine, 33(4), pp.211~218 (2012), 대한가정의학회[DOI]
- Mizuno Y, "East Asian variant of aldehyde dehydrogenase 2 is associated with coronary spastic angina : possible roles of reactive aldehydes and implications of alcohol flushing syndrome", Circulation, 131, pp.1665~1673 (2015)
- Zhang J, "Facial flushing after alcohol consumption and the risk of cancer: a meta-analysis", Medicine (Baltimore), 96, pp.e6506~ (2017)
- Masaoka H, "Alcohol consumption and bladder cancer risk with or without the flushing response : the Japan Public Health Center-based Prospective Study", Int J Cancer, 141, pp.2480~2488 (2017)
- Kim NH, "Risk of the development of diabetes and cardiovascular disease in metabolically healthy obese people: the Korean genome and epidemiology study", Medicine(Baltimore), 95, pp.e3384~ (2016)
- DeMarco VG, "The pathophysiology of hyperten-sion in patients with obesity", Nat Rev Endocrinol, 10, pp.364~376 (2014)
- Gallagher EJ, "Obesity and diabetes : the increased risk of cancer and cancer-related mortality", Physiol Rev, 95, pp.727~748 (2015)
- The Asia-Pacific perspective: redefining obesity and its treatment, "World Health Organization", Health Communications Australia, ~ (2000)
- Yokoyama A, "Reliability of a flushing questionnaire and the ethanol patch test in screening for inactive aldehyde dehydrogenase-2 and alcohol-related cancer risk", Cancer Epidemiol Biomarkers Prev, 6, pp.1105~1107 (1997)
- Willenbring ML, "Helping patients who drink too much : an evidence-based guide for primary care clinicians", Am Fam Physician, 80, pp.44~50 (2009)
- Haskell WL, "Physical activity and public health : updated recommendation for adults from the American College of Sports Medicine and the American Heart Association", Med Sci Sports Exerc, 39, pp.1423~1434 (2007)
- American Diabetes Association, "2. Classification and diagnosis of diabetes: standards of medical care in diabetes—2017", Diabetes Care, 40(Suppl 1), pp.S11~S24 (2017)
- International Diabetes Federation, "IDF Diabetes Atlas" (2015), International Diabetes Federation
- Garg SK, "Diabetes and cancer : two diseases with obesity as a common risk factor", Diabetes Obes Metab, 16, pp.97~110 (2014)
- Eckel RH, "Obesity and type 2 diabetes : what can be unified and what needs to be individualized?", J Clin Endocrinol Metab, 96, pp.1654~1663 (2011)
- Knott C, "Alcohol consumption and the risk of type 2diabetes : a systematic review and dose-response meta-analysis of more than 1. 9 million individuals from 38 observational studies", Diabetes Care, 38, pp.1804~1812 (2015)
- Cullmann M, "Alcohol consumption and risk of pre-diabetes and type 2 diabetes development in a Swedish population", Diabet Med, 29, pp.441~452 (2012)
- Li XH, "Association between alcohol consumption and the risk of incident type 2 diabetes : a systematic review and dose-response meta-analysis", Am J Clin Nutr, 103, pp.818~829 (2016)
- Jung JG, "The role of the flushing response in the relationship between alcohol consumption and insulin resistance", Alcohol Clin Exp Res, 34, pp.1699~1704 (2010)
- Kuwahara K, "Flushing response modifies the association of alcohol consumption with markers of glucose metabolism in Japanese men and women", Alcohol Clin Exp Res, 38, pp.1042~1048 (2014)
- Chandrasekaran K, "In vitro evidence for chronic alcohol and high glucose mediated increased oxidative stress and hepatotoxicity", Alcohol Clin Exp Res, 36, pp.1004~1012 (2012)
- Roh WG, "Alcohol consumption and higher incidence of impaired fasting glucose or type 2 diabetes in obese Korean men", Alcohol, 43, pp.643~648 (2009)
- Frohnert BI, "Increased adipose protein carbonylation in human obesity", Obesity(Silver Spring), 19, pp.1735~1741 (2011)
- Ohsawa I, "Deficiency in a mitochondrial aldehyde dehydrogenase increases vulnerability to oxidative stress in PC12 cells", J Neurochem, 84, pp.1110~1117 (2003)