음주연관 안면홍조에 따른 혈중 요산과 호모시스테인 농도 관계의 변화
The Relationship between Uric Acid and Homocysteine Levels based on Alcohol-related Facial Flushing
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연구배경: 본 연구는 음주연관 안면 홍조 여부에 따라 혈중 요산과 호모시스테인 농도의 연관 관계가 다른지를 분석하였다. 방법: 2013년 3월부터 2014년 2월까지 대전의 한 대학병원에 건강검진을 목적으로 내원한 성인 남성 중 702명(비안면홍조자 401명, 홍조자 301명)을 대상으로 하였다. 비안면홍조자 그룹과 안면 홍조자 그룹에서 로그 호모시스테인과 요산을 포함한 다른 변수들과의 관계를 Pearson’s correlation과 stepwise multivariate linear regression analyses로분석하였다. 결과: 비안면홍조군에서 혈중 요산 농도와 로그 호모시스테인은 유의한 양의 연관관계를 보였다(γ=0.166, P=0.001) (ß=0.176; P=0.001). 하지만 홍조군에서는 어느 변수도 로그호모시스테인과 유의한 연관관계를 보이지 않았다. 결론: 음주관련 안면홍조가 없는 음주자의 경우 혈중 요산과 호모시스테인 농도의 연관관계는 양의 연관관계를보이지만, 음주관련 안면홍조가 있는 경우에는 연관관계를 보이지 않는다고 판단된다.
Abstract
Background: This study aimed to determine the correlation between blood uric acid and homocysteine levels, based on alcohol-related facial flushing. Methods: Among male adults who visited a health examination center of a university hospital located in Daejeon, Korea, for a personal health examination from March 2013 to February 2014, 702 subjects were analyzed including 401 subjects without alcohol-related facial flushing and 301 with facial flushing. Pearson’s correlation and stepwise multivariate linear regression analyses were performed between the log homocysteine levels and other variables including uric acid. Results: Uric acid showed a significant positive correlation with log homocysteine (γ=0.166, P=0.001) (ß=0.176; P=0.001) in the non-flushing group. In contrast, none of the variables showed any significant correlations with log homocysteine in the flushing group. Conclusions: Alcohol users not exhibiting alcohol-related facial flushing showed a positive correlation between uric acid and homocysteine levels, whereas those without facial flushing showed no such correlation.
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