Korean Alcohol Guidelines for Moderate Drinking Based on Facial Flushing
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참고문헌
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초록
This study investigated advantages and potential risks associated with drinking alcohol in Koreans based on the al-cohol flush reaction. Our investigation reviewed published studies and examined moderate-drinking levels for Ko-reans based on modified National Institute on Alcohol Abuse and Alcoholism guidelines. Fourteen articles out of a total 198 publications were searched using PubMed, EMBASE, KoreaMed, and RISS (Research Information Sharing Service) databases and selected for review. Individuals without alcohol flush reaction (non-flushers) exhibited low-er risks associated with insulin resistance, metabolic syndrome, and hyperhomocysteinemia and their 10-year car-diovascular disease risk when alcohol consumption was ≤8 drinks/wk. Conversely, risks associated with insulin re-sistance, metabolic syndrome, high blood pressure, prediabetes or type-2 diabetes, and high intraocular pressure and increases in carbohydrate-deficient transferrin, gamma glutamyl transferase, and blood glucose levels were present when >8 drinks were consumed. For individuals with flushing reaction (flushers), advantages were report-ed in relation to risks of hyperhomocysteinemia when alcohol consumption was ≤4 drinks/wk, whereas consump-tion of >4 drinks/wk increased the risk of insulin resistance, metabolic syndrome, high blood pressure, pre-diabetes or type-2 diabetes, high-risk colorectal adenoma, and high intraocular pressure and increased carbohydrate-defi-cient transferrin, gamma glutamyl transferase, and blood glucose levels. The moderate drinking level for Koreans is ≤8 drinks/wk for men aged ≤65 years and ≤4 drinks/wk for men aged over 65. For women, these limits should be half of those for men. Furthermore, individuals with flushing reaction should maintain an alcohol consumption level half of that for non-flushers.
Abstract
This study investigated advantages and potential risks associated with drinking alcohol in Koreans based on the al-cohol flush reaction. Our investigation reviewed published studies and examined moderate-drinking levels for Ko-reans based on modified National Institute on Alcohol Abuse and Alcoholism guidelines. Fourteen articles out of a total 198 publications were searched using PubMed, EMBASE, KoreaMed, and RISS (Research Information Sharing Service) databases and selected for review. Individuals without alcohol flush reaction (non-flushers) exhibited low-er risks associated with insulin resistance, metabolic syndrome, and hyperhomocysteinemia and their 10-year car-diovascular disease risk when alcohol consumption was ≤8 drinks/wk. Conversely, risks associated with insulin re-sistance, metabolic syndrome, high blood pressure, prediabetes or type-2 diabetes, and high intraocular pressure and increases in carbohydrate-deficient transferrin, gamma glutamyl transferase, and blood glucose levels were present when >8 drinks were consumed. For individuals with flushing reaction (flushers), advantages were report-ed in relation to risks of hyperhomocysteinemia when alcohol consumption was ≤4 drinks/wk, whereas consump-tion of >4 drinks/wk increased the risk of insulin resistance, metabolic syndrome, high blood pressure, pre-diabetes or type-2 diabetes, high-risk colorectal adenoma, and high intraocular pressure and increased carbohydrate-defi-cient transferrin, gamma glutamyl transferase, and blood glucose levels. The moderate drinking level for Koreans is ≤8 drinks/wk for men aged ≤65 years and ≤4 drinks/wk for men aged over 65. For women, these limits should be half of those for men. Furthermore, individuals with flushing reaction should maintain an alcohol consumption level half of that for non-flushers.
참고문헌 (31)
- "Global status report on alcohol and health 2014" (2014)[URL]
- "The Survey of Mental Disorders in Korea 2016 with adjustment of sex and age" (2017)[URL]
- "Helping patients who drink too much: a clinician’s guide" (2007)[URL]
- Korean Ministry of Health and Welfare, "2018Counseling Manual of National Health Screening Program", Korean Centers for Disease Control & Prevention, ~ (2017)
- "AUDIT: the Alcohol Use Disorders Identification Test: guidelines for use in primary care" (2001)[URL]
- Agarwal DP, "Racial differences in biological sensitivity to ethanol : the role of alcohol dehydrogenase and aldehyde dehydrogenase isozymes", Alcohol Clin Exp Res, 5, pp.12~16 (1981)
- Mizoi Y, "Alcohol sensitivity related to polymorphism of alcohol-metabolizing enzymes in Japanese", Pharmacol Biochem Behav, 18(Suppl 1), pp.127~133 (1983)
- Crabb DW, "Ethanol oxidizing enzymes : roles in alcohol metabolism and alcoholic liver disease", Prog Liver Dis, 13, pp.151~172 (1995)
- Mizoi Y, "Relationship between facial flushing and blood acetaldehyde levels after alcohol intake", Pharmacol Biochem Behav, 10, pp.303~311 (1979)
- Yokoyama A, "Reliability of a flushing questionnaire and the ethanol patch test in screening for inactive aldehyde dehydrogenase-2 and alcohol-related cancer risk", Cancer Epidemiol Biomarkers Prev, 6, pp.1105~1107 (1997)
- Shin CM, "Validation of alcohol flushing questionnaires in determining inactive aldehyde dehydrogenase-2and its clinical implication in alcohol-related diseases", Alcohol Clin Exp Res, 42, pp.387~396 (2018)
- Jung JG, "The role of the flushing response in the relationship between alcohol consumption and insulin resistance", Alcohol Clin Exp Res, 34, pp.1699~1704 (2010)
- Jung JG, "Relationships among alcohol consumption, facial flushing response, and metabolic syndrome in healthy men", Ann Epidemiol, 22, pp.480~486 (2012)
- Hae Sun Suh, "Influence of the Flushing Response in the Relationship between Alcohol Consumption and Cardiovascular Disease Risk", Korean Journal of Family Medicine, 35(6), pp.295~302 (2014), 대한가정의학회
- 김어진, "Effect of Alcohol Consumption on Risk of Hyperhomocysteinemia Based on Alcohol-Related Facial Flushing Response", Korean Journal of Family Medicine, 34(4), pp.250~257 (2013), 대한가정의학회
- 김규필, "남성에서 안면홍조 유무에 따른 주당 음주량과 이상지질혈증과의관계", Korean Journal of Health Promotion, 16(3), pp.153~161 (2016), 대한임상건강증진학회[DOI]
- 장학선, "Relationship Between Alcohol Consumption and Prostatic Hyperplasia According to Facial Flushing After Drinking in Korean Men", Korean Journal of Family Medicine, 38(2), pp.93~98 (2017), 대한가정의학회
- Seo YR, "Relationship between alcohol consumption and metabolic syndrome according to facial flushing in Korean females", pp.2018
- 김성구, "Relationships between the Level of Alcohol Consumption and Abnormality in Biomarkers According to Facial Flushing in Korean Male Drinkers", Korean Journal of Family Medicine, 34(2), pp.123~130 (2013), 대한가정의학회
- Jun-Seok Yang, "Drinking Amount Associated with Abnormal Gamma-Glutamyl Transpeptidase Expression in Women", Korean Journal of Family Medicine, 37(1), pp.2~6 (2016), 대한가정의학회
- Jung JG, "Hypertension associated with alcohol consumption based on the facial flushing reaction to drinking", Alcohol Clin Exp Res, 38, pp.1020~1025 (2014)
- Suh WY, "Facial flushing after drinking as determinant for effect of weekly drinking amount on impaired fasting glucose or type 2 diabetes", master’s, pp.2014
- Kim JH, "Influence of facial flushing on pre- or type 2 diabetes risk according to alcohol consumption in Korean male", Korean J Fam Med (2019)
- Yang HJ, "Alcohol flushing response magnifies the association of alcohol consumption with colorectal high risk adenoma in Korean men", master’s, pp.2016
- Sami Lee, "Relationship between Alcohol Consumption and Ocular Pressure according to Facial Flushing in Korean Men with Obesity", Korean Journal of Family Medicine, 40(6), pp.399~405 (2019), 대한가정의학회[DOI]
- "Alcohol facts and statistics" (2018)[URL]
- Shibuya A, "Genotype of alcohol dehydrogenase and aldehyde dehydrogenase loci in Japanese alcohol flushers and nonflushers", Hum Genet, 82, pp.14~16 (1989)
- Frezza M, "High blood alcohol levels in women : the role of decreased gastric alcohol dehydrogenase activity and first-pass metabolism", N Engl J Med, 322, pp.95~99 (1990)
- Mumenthaler MS, "Gender differences in moderate drinking effects", Alcohol Res Health, 23, pp.55~64 (1999)
- "Mean body weight, height, waist circumference, and body mass index among adults:United States, 1999-2000 through 2015-2016" (2018)[URL]
- "The 2017 National Health Insurance statistical yearbook" (2018)[URL]