한국 성인 여성의 n-3계, n-6계 지방산 섭취와 우울증상: 2014-2018년 국민건강영양조사를 이용하여
N-3 and N-6 Fatty Acid Intakes and Depressive Symptoms in Korean Female Adults Population Using Data from the 2014-2018 Korea National Health and Nutrition Examination Survey
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초록
연구배경: 본 연구는 한국 성인 여성을 대상으로 n-3계, n-6계 지방산 섭취와 우울증상과의 관계를 살펴보고자 하였다. 방법: 본 연구는 2014-2018년 국민건강영양조사에 참여한19세 이상 성인 여성 8,204명을 대상으로 하여 PHQ-9 판별기준에 따라 저우울증상군과 고우울증상군으로 분류하였다. 대상자의 에너지 및 지방산 섭취량은 국민건강영양조사의 영양조사 중 1일 24시간 회상법을 통해 얻어진 자료를활용하여 산출하였다. 결과: 본 연구 결과 고우울증상군은 저우울증상군에 비해교육수준과 소득수준이 낮고, 건강행태 요인으로 흡연율이높고, 신체활동률이 낮았다. 41-64세 연령대에서 n-3계 지방산 중 DPA와 n-6계 지방산 중 아라키돈산 섭취량이 증가할수록 우울증 유병 위험도가 감소하였고(95% CI, 0.33-0.93), 65세 이상 연령대에서 총 n-3계 지방산과 n-3계 지방산 중DHA 섭취량이 증가할수록 우울증 유병 위험도가 감소하여(95% CI, 0.35-0.90) 연령대별 차이를 보였다. n-6:n-3 비율은 우울증 유병 위험도와 관련성을 보이지 않았다. 결론: 본 연구 결과 한국 성인 여성의 n-3계 지방산과 아라키돈산의 섭취는 우울증상과 연관성이 있는 것으로 나타났다.
Abstract
Background: This study sought to investigate the association between n-3 and n-6 fatty acid intakes and depressive symptoms in Korean female adults. Methods: Subjects comprised 8,204 Korean female adults, aged over 19 years, who participated in the National Health and Nutrition Examination Survey from 2014-2018. Subjects were classified according to their Patient Health Questionnaire-9 scores into a low depressive symptoms (LDS) group and a high depressive symptoms (HDS) group. Nutrient intake was evaluated using dietary data obtained through a one-day 24-hour recall. Results: Compared with the LDS group, the HDS group was associated with lower education levels, household incomes, and employment rates. The HDS group had lower intakes of n-3 and n-6 fatty acids than the LDS group. The highest quartile of adjusted total n-3 intakes had a decreased odds ratio of depressive symptoms (95% confidence interval [CI], 0.35-0.90) in those aged 65 years over. The prevalence of depressive symptoms decreased in the highest quartile of adjusted arachidonic acid intake (95% CI, 0.33-0.93) in those aged 41-64 years. The n-6:n-3 ratio was not associated with depressive symptoms. Conclusions: From the results of this study, it was found that the intake of n-3 fatty acids and arachidonic acid were significantly associated with depressive symptoms. These findings can be used to aid the development of dietary guidelines for the improvement of public health.
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