Expression of the ATP-gated P2X7 Receptor on M Cells and Its Modulating Role in the Mucosal Immune Environment
1
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Interactions between microbes and epithelial cells in the gastrointestinal tract are closely associated with regulation of intestinal mucosal immune responses. Recent studies have highlighted the modulation of mucosal immunity by microbe-derived molecules such as ATP and short-chain fatty acids. In this study, we undertook to characterize the expression of the ATP-gated P2X7 receptor (P2X7R) on M cells and its role in gastrointestinal mucosal immune regulation because it was poorly characterized in Peyer's patches, although purinergic signaling via P2X7R and luminal ATP have been considered to play an important role in the gastrointestinal tract. Here, we present the first report on the expression of P2X7R on M cells and characterize the role of P2X7R in immune enhancement by ATP or LL-37.
Abstract
Interactions between microbes and epithelial cells in the gastrointestinal tract are closely associated with regulation of intestinal mucosal immune responses. Recent studies have highlighted the modulation of mucosal immunity by microbe-derived molecules such as ATP and short-chain fatty acids. In this study, we undertook to characterize the expression of the ATP-gated P2X7 receptor (P2X7R) on M cells and its role in gastrointestinal mucosal immune regulation because it was poorly characterized in Peyer's patches, although purinergic signaling via P2X7R and luminal ATP have been considered to play an important role in the gastrointestinal tract. Here, we present the first report on the expression of P2X7R on M cells and characterize the role of P2X7R in immune enhancement by ATP or LL-37.
참고문헌 (21)
- Cerutti, A., "Regulation of mucosal IgA responses: lessons from primary immunodeficiencies", Ann. N. Y. Acad. Sci, 1238, pp.132~144 (2011)
- Rescigno, M., "The intestinal epithelial barrier in the control of homeostasis and immunity", Trends Immunol, 32, pp.256~264 (2011)
- Corr, S. C., "M-cells: origin, morphology and role in mucosal immunity and microbial pathogenesis", FEMS Immunol. Med. Microbiol, 52, pp.2~12 (2008)
- 김새해, "Mucosal Immune System and M Cell-targeting Strategies for Oral Mucosal Vaccination", Immune Network, 12(5), pp.165~175 (2012), 대한면역학회[DOI]
- Mabbott, N. A., "Microfold (M) cells: important immunosurveillance posts in the intestinal epithelium", Mucosal Immunol, 6, pp.666~677 (2013)
- Kim, S. H., "M cells expressing the complement C5a receptor are efficient targets for mucosal vaccine delivery", Eur. J. Immunol, 41, pp.3219~3229 (2011)
- Kamada, N., "Role of the gut microbiota in the development and function of lymphoid cells", J. Immunol, 190, pp.1389~1395 (2013)
- Rimoldi, M., "Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells", Nat. Immunol, 6, pp.507~514 (2005)
- Iliev, I. D., "Intestinal epithelial cells promote colitis-protective regulatory T-cell differentiation through den dritic cell conditioning", Mucosal Immunol, 2, pp.340~350 (2009)
- Kabat, A. M., "Modulation of immune development and function by intestinal microbiota", Trends Immunol, 35, pp.507~517 (2014)
- Burnstock, G., "ATP-gated P2X receptors in health and disease", Front. Cell. Neurosci, 8, pp.204~ (2014)
- Atarashi, K., "ATP drives lamina propria T(H)17 cell differentiation", Nature, 455, pp.808~812 (2008)
- Arulkumaran, N., "A potential therapeutic role for P2X7 receptor (P2X7R) antagonists in the treatment of inflammatory diseases", Expert Opin. Investig. Drugs, 20, pp.897~915 (2011)
- Cesaro, A., "Amplification loop of the inflammatory process is induced by P2X7R activation in intestinal epithelial cells in response to neutrophil transepithelial migration", Am. J. Physiol. Gastrointest. Liver Physiol, 299, pp.G32~G42 (2010)
- Kim, S. H., "The M cell-targeting ligand promotes antigen delivery and induces antigen-specific immune responses in mucosal vaccination", J. Immunol, 185, pp.5787~5795 (2010)
- Kim, S. H., "Application of an M-cell-targeting ligand for oral vaccination induces efficient systemic and mucosal immune responses against a viral antigen", Int. Immunol, 25, pp.623~632 (2013)
- North, R. A., "Molecular physiology of P2X receptors", Physiol. Rev, 82, pp.1013~1067 (2002)
- Ferrari, D., "The P2X7 receptor:a key player in IL-1 processing and release", J. Immunol, 176, pp.3877~3883 (2006)
- Bucki, R., "Cathelicidin LL-37: a multitask antimicrobial peptide", Arch. Immunol. Ther. Exp. (Warsz.), 58, pp.15~25 (2010)
- Yu, J., "Host defense peptide LL-37, in synergy with inflammatory mediator IL-1beta, augments immune responses by multiple pathways", J. Immunol, 179, pp.7684~7691 (2007)
- Lycke, N. Y., "The role of Peyer's patches in synchronizing gut IgA responses", Front. Immunol, 3, pp.329~ (2012)