본문 바로가기
KERD
논문KCI 등재

Regulation of Intestinal Immune System by Dendritic Cells

2

조회

0

다운로드

2

인용

0

참고문헌

키워드

초록

Innate immune cells survey antigenic materials beneath ourbody surfaces and provide a front-line response to internaland external danger signals. Dendritic cells (DCs), a subsetof innate immune cells, are critical sentinels that performmultiple roles in immune responses, from acting as principalmodulators to priming an adaptive immune response throughantigen-specific signaling. In the gut, DCs meet exogenous,non-harmful food antigens as well as vast commensal microbesunder steady-state conditions. In other instances,they must combat pathogenic microbes to prevent infections. In this review, we focus on the function of intestinal DCs inmaintaining intestinal immune homeostasis. Specifically, wedescribe how intestinal DCs affect IgA production from Bcells and influence the generation of unique subsets of T cell.

Abstract

Innate immune cells survey antigenic materials beneath ourbody surfaces and provide a front-line response to internaland external danger signals. Dendritic cells (DCs), a subsetof innate immune cells, are critical sentinels that performmultiple roles in immune responses, from acting as principalmodulators to priming an adaptive immune response throughantigen-specific signaling. In the gut, DCs meet exogenous,non-harmful food antigens as well as vast commensal microbesunder steady-state conditions. In other instances,they must combat pathogenic microbes to prevent infections. In this review, we focus on the function of intestinal DCs inmaintaining intestinal immune homeostasis. Specifically, wedescribe how intestinal DCs affect IgA production from Bcells and influence the generation of unique subsets of T cell.

참고문헌 (53)

  1. Murphy, K., "Janeway's immunobiology", pp.466~468 (2012), Garland Science
  2. Ciorba, M. A., "Lactobacillus probiotic protects intestinal epithelium from radiation injury in a TLR-2", cyclo-oxygenase-2-dependent manner, 2012, pp.61, 829~838
  3. Fukuda, S., "Bifidobacteria can protect from enteropathogenic infection through production of acetate", Nature, 469, pp.543~547 (2011)
  4. Pickard, J. M., "Rapid fucosylation of intestinal epithelium sustains host-commensal symbiosis in sickness", Nature, 514, pp.638~641 (2014)
  5. Denning, T. L., "Functional specializations of intestinal dendritic cell and macrophage subsets that control Th17 and regulatory T cell responses are dependent on the T cell", APC ratio, source of mouse strain, and regional localization, 2011, ~
  6. Varol, C., "Intestinal lamina propria dendritic cell subsets have different origin and functions", Immunity, 31, pp.502~512 (2009)
  7. Edelson, B. T., "Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8alpha+ conventional dendritic cells", J. Exp. Med, 207 (2010)
  8. Forster, R., "CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs", Cell, 99, pp.23~33 (1999)
  9. Jang, M. H., "CCR7 is critically important for migration of dendritic cells in intestinal lamina propria to mesenteric lymph nodes", J. Immunol, 176 (2006)
  10. Persson, E. K., "The diverse ontogeny and function of murine small intestinal dendritic cell", macrophage subsets, 2010, pp.215, 692~697
  11. Helft, J., "Origin and functional heterogeneity of non-lymphoid tissue dendritic cells in mice", Immunol. Rev, 234, pp.55~75 (2010)
  12. Bogunovic, M., "Origin of the lamina propria dendritic cell network", Immunity, 31, pp.513~525 (2009)
  13. Tezuka, H., "Regulation of IgA production by naturally occurring TNF", iNOS-producing dendritic cells, 2007, pp.448, 929~933
  14. Mucida, D., "Oral tolerance in the absence of naturally occurring Tregs", J. Clin. Invest, 115, pp.1923~1933 (2005)
  15. McDole, J. R., "Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine", Nature, 483, pp.345~349 (2012)
  16. Farache, J., "Luminal bacteria recruit CD103+ dendritic cells into the intestinal epithelium to sample bacterial antigens for presentation", Immunity, 38, pp.581~595 (2013)
  17. Coombes, J. L., "A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism", J. Exp. Med, 204, pp.1757~1764 (2007)
  18. Sun, C. M., "Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 Treg cells via retinoic acid", J. Exp. Med, 204, pp.1775~1785 (2007)
  19. Mucida, D., "Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid", Science, 317, pp.256~260 (2007)
  20. Denning, T. L., "Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses", Nat. Immunol, 8, pp.1086~1094 (2007)
  21. Hadis, U., "Intestinal tolerance requires gut homing and expansion of Foxp3+ regulatory T cells in the lamina propria", Immunity, 34, pp.37~246 (2011)
  22. Niess, J. H., "CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance", Science, 307, pp.254~258 (2005)
  23. Mazzini, E., "Oral tolerance can be established via gap junction transfer of fed antigens from CX3CR1(+)macrophages to CD103(+)dendritic cells", Immunity, 40, pp.248~261 (2014)
  24. Chang, S. Y., "Circulatory antigen processing by mucosal dendritic cells controls CD8(+)T cell activation", Immunity, 38, pp.153~165 (2013)
  25. Longman, R. S., "CX(3)CR1(+) mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22", J. Exp. Med, 211, pp.1571~1583 (2014)
  26. Dasgupta, S., "Plasmacytoid dendritic cells mediate anti-inflammatory responses to a gut commensal molecule via both innate and adaptive mechanisms", Cell Host Microbe, 15, pp.413~423 (2014)
  27. Lee, S. E., "Type I interferons maintain Foxp3 expression and T-regulatory cell functions under inflammatory conditions in mice", Gastroenterology, 143, pp.145~154 (2012)
  28. Kole, A., "Type I IFNs regulate effector and regulatory T cell accumulation and anti-inflammatory cytokine production during T cell-mediated colitis", J. Immunol, 191, pp.2771~2779 (2013)
  29. Schulz, O., "Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions", J. Exp. Med, 206, pp.3101~3114 (2009)
  30. Jaensson, E., "Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans", J. Exp. Med, 205, pp.2139~2149 (2008)
  31. Ivanov, I. I., "Induction of intestinal Th17cells by segmented filamentous bacteria", Cell, 139, pp.485~498 (2009)
  32. Goto, Y., "Segmented filamentous bacteria antigens presented by intestinal dendritic cells drive mucosal Th17 cell differentiation", Immunity, 40, pp.594~607 (2014)
  33. Yang, Y., "Focused specificity of intestinal TH17 cells towards commensal bacterial antigens", Nature, 510, pp.152~156 (2014)
  34. Persson, E. K., "IRF4 transcription-factor-dependent CD103(+)CD11b(+)dendritic cells drive mucosal T helper 17 cell differentiation", Immunity, 38, pp.958~969 (2013)
  35. Kinnebrew, M. A., "Interleukin 23 production by intestinal CD103(+)CD11b(+)dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense", Immunity, 36, pp.276~287 (2012)
  36. Uematsu, S., "Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5. Nat. Immunol. 9 : 769-776" (2008)
  37. Fujimoto, K., "A new subset of CD103+CD8alpha+ dendritic cells in the small intestine expresses TLR3, TLR7, and TLR9 and induces Th1 response and CTL activity", J. Immunol, 186, pp.6287~6295 (2011)
  38. Lecuyer, E., "Segmented filamentous bacterium uses secondary and tertiary lymphoid tissues to induce gut IgA and specific T helper 17 cell responses", Immunity, 40, pp.608~620 (2014)
  39. Palm, N. W., "Immunoglobulin A coating identifies colitogenic bacteria in inflammatory bowel disease", Cell, 158, pp.1000~1010 (2014)
  40. Tezuka, H., "Prominent role for plasmacytoid dendritic cells in mucosal T cell-independent IgA induction", Immunity, 34, pp.247~257 (2011)
  41. Molenaar, R., "Expression of retinaldehyde dehydrogenase enzymes in mucosal dendritic cells and gut-draining lymph node stromal cells is controlled by dietary vitamin A", J. Immunol, 186, pp.1934~1942 (2011)
  42. Mora, J. R., "Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells", Science, 314, pp.1157~1160 (2006)
  43. Chang, S. Y., "Cutting edge: Langerin+ dendritic cells in the mesenteric lymph node set the stage for skin and gut immune system cross-talk", J. Immunol, 180, pp.4361~4365 (2008)
  44. Iwata, M., "Retinoic acid imprints gut-homing specificity on T cells", Immunity, 21, pp.527~538 (2004)
  45. Chang, S. Y., "Lack of retinoic acid leads to increased langerin-expressing dendritic cells in gut-associated lymphoid tissues", Gastroenterology, 138, pp.1468~1478 (2010)
  46. Chang, S. Y., "Langerin-expressing dendritic cells in gut-associated lymphoid tissues", Immunol. Rev, 234, pp.233~246 (2010)
  47. Sutherland, D. B., "Gut reactions:Eosinophils add another string to their bow", Immunity, 40, pp.455~457 (2014)
  48. Chu, V. T., "Eosinophils promote generation and maintenance of immunoglobulin-A-expressing plasma cells and contribute to gut immune homeostasis", Immunity, 40, pp.582~593 (2014)
  49. Chu, D. K., "Indigenous enteric eosinophils control DCs to initiate a primary Th2 immune response in vivo", J. Exp. Med, 211, pp.1657~1672 (2014)
  50. Atarashi, K., "Induction of colonic regulatory T cells by indigenous Clostridium species", Science, 331, pp.337~341 (2011)
  51. Atarashi, K., "Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota", Nature, 500, pp.232~236 (2013)
  52. Benson, M. J., "All-trans retinoic acid mediates enhanced Treg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation1", J. Exp. Med, 204, pp.1765~1774 (2007)
  53. Mora, J. R., "Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells", Nature, 424, pp.88~93 (2003)

이 간행물의 다른 논문 (5건)