Regulation of Intestinal Homeostasis by Innate Immune Cells
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The intestinal immune system has an ability to distinguish between the microbiota and pathogenic bacteria, and then activate pro-inflammatory pathways against pathogens for host defense while remaining unresponsive to the microbiota and dietary antigens. In the intestine, abnormal activation of innate immunity causes development of several inflammatory disorders such as inflammatory bowel diseases (IBD). Thus, activity of innate immunity is finely regulated in the intestine. To date, multiple innate immune cells have been shown to maintain gut homeostasis by preventing inadequate adaptive immune responses in the murine intestine. Additionally, several innate immune subsets, which promote Th1 and Th17 responses and are implicated in the pathogenesis of IBD, have recently been identified in the human intestinal mucosa. The demonstration of both murine and human intestinal innate immune subsets contributing to regulation of adaptive immunity emphasizes the conserved innate immune functions across species and might promote development of the intestinal innate immunity-based clinical therapy.
Abstract
The intestinal immune system has an ability to distinguish between the microbiota and pathogenic bacteria, and then activate pro-inflammatory pathways against pathogens for host defense while remaining unresponsive to the microbiota and dietary antigens. In the intestine, abnormal activation of innate immunity causes development of several inflammatory disorders such as inflammatory bowel diseases (IBD). Thus, activity of innate immunity is finely regulated in the intestine. To date, multiple innate immune cells have been shown to maintain gut homeostasis by preventing inadequate adaptive immune responses in the murine intestine. Additionally, several innate immune subsets, which promote Th1 and Th17 responses and are implicated in the pathogenesis of IBD, have recently been identified in the human intestinal mucosa. The demonstration of both murine and human intestinal innate immune subsets contributing to regulation of adaptive immunity emphasizes the conserved innate immune functions across species and might promote development of the intestinal innate immunity-based clinical therapy.
참고문헌 (43)
- Maloy, K. J., "IL-23 and Th17 cytokines in intestinal homeostasis", Mucosal Immunol, 1, pp.339~349 (2008)
- Shevach, E. M., "Mechanisms of Foxp3＋ T regulatory cell-mediated suppression", Immunity, 30, pp.636~645 (2009)
- Sakaguchi, S., "The origin of Foxp3-expressing CD4＋ regulatory T cells: thymus or periphery", J. Clin. Invest, 112, pp.1310~1312 (2003)
- Asseman, C., "An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation", J. Exp. Med, 190, pp.995~1004 (1999)
- Garrett, W. S., "Homeostasis and inflammation in the intestine", Cell, 140, pp.859~870 (2010)
- Renz, H., "The impact of perinatal immune development on mucosal homeostasis and chronic inflammation", Nat. Rev. Immunol, 12, pp.9~23 (2011)
- Maloy, K. J., "Intestinal homeostasis and its breakdown in inflammatory bowel disease", Nature, 474, pp.298~306 (2011)
- Franke, A., "Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci", Nat. Genet, 42, pp.1118~1125 (2010)
- Anderson C. A., "Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47", Nat. Genet, 43, pp.246~252 (2011)
- Strober, W, "The multifaceted influence of the mucosal microflora on mucosal dendritic cell responses", Immunity, 31, pp.377~388 (2009)
- Varol, C., "Securing the immune tightrope: mononuclear phagocytes in the intestinal lamina propria", Nat. Rev. Immunol, 10, pp.415~426 (2010)
- Coombes, J. L., "Dendritic cells in intestinal immune regulation", Nat. Rev. Immunol, 8, pp.435~446 (2008)
- Laffont, S., "Immunology: Dendritic-cell genealogy", Nature, 462, pp.732~733 (2009)
- Varol, C., "Intestinal lamina propria dendritic cell subsets have different origin and functions", Immunity, 31, pp.502~512 (2009)
- Niess, J. H., "Enteric flora expands gut lamina propria CX3CR1＋ dendritic cells supporting inflammatory immune responses under normal and inflammatory conditions", J. Immunol, 184, pp.2026~2037 (2010)
- Bogunovic, M., "Origin of the lamina propria dendritic cell network", Immunity, 31, pp.513~525 (2009)
- Fujimoto, K., "A new subset of CD103＋CD8alpha＋ dendritic cells in the small intestine expresses TLR3, TLR7, and TLR9 and induces Th1 response and CTL activity", J. Immunol, 186, pp.6287~6295 (2011)
- Jaensson, E., "Small intestinal CD103＋ dendritic cells display unique functional properties that are conserved between mice and humans", J. Exp. Med, 205, pp.2139~2149 (2008)
- Schulz, O., "Intestinal CD103＋, but not CX3CR1＋, antigen sampling cells migrate in lymph and serve classical dendritic cell functions", J. Exp. Med, 206, pp.3101~3114 (2009)
- Persson, E. K., "IRF4 transcription-factor-dependent CD103(＋)CD11b(＋) dendritic cells drive mucosal T helper 17 cell differentiation", Immunity, 38, pp.958~969 (2013)
- Schlitzer, A., "IRF4 transcription factor-dependent CD11b＋ dendritic cells in human and mouse control mucosal IL-17 cytokine responses", Immunity, 38, pp.970~983 (2013)
- Uematsu, S., "Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5. Nat", Immunol, 9, pp.769~776 (2008)
- Kinnebrew, M. A., "Interleukin 23 production by intestinal CD103(＋)CD11b(＋) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense", Immunity, 36, pp.276~287 (2012)
- Johansson-Lindbom, B., "Functional specialization of gut CD103＋ dendritic cells in the regulation of tissue-selective T cell homing", J. Exp. Med, 202, pp.1063~1073 (2005)
- Sun, C. M., "Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid", J. Exp. Med, 204, pp.1775~1785 (2007)
- Jeon, S. G., "Probiotic Bifidobacterium breve induces IL-10-producing Tr1 cells in the colon", PLoS Pathog, 8, pp.e1002714~ (2012)
- Niess, J. H., "CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance", Science, 307, pp.254~258 (2005)
- Atarashi, K., "ATP drives lamina propria T(H)17 cell differentiation", Nature, 455, pp.808~812 (2008)
- Denning, T. L., "Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses", Nat. Immunol, 8, pp.1086~1094 (2007)
- Hadis, U., "Intestinal tolerance requires gut homing and expansion of Foxp3＋ regulatory T cells in the lamina propria", Immunity, 34, pp.237~246 (2011)
- Medina-Contreras, O., "CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation, and colitogenic Th17 responses in mice", J. Clin. Invest, 121, pp.4787~4795 (2011)
- Chang, S. Y., "Circulatory antigen processing by mucosal dendritic cells controls CD8(＋) T cell activation", Immunity, 38, pp.153~165 (2013)
- Kayama, H., "Intestinal CX3C chemokine receptor 1(high) (CX3CR1(high)) myeloid cells prevent T-cell-dependent colitis", Proc. Natl. Acad. Sci. U. S. A, 109, pp.5010~5015 (2012)
- Ueda, Y., "Commensal microbiota induce LPS hyporesponsiveness in colonic macrophages via the production of IL-10. Int", Immunol, 22, pp.953~962 (2010)
- Takeda, K., "Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils", Immunity, 10, pp.39~49 (1999)
- Kuhn, R., "Interleukin-10-deficient mice develop chronic enterocolitis", Cell, 75, pp.263~274 (1993)
- Murai, M., "Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis", Nat. Immunol, 10, pp.1178~1184 (2009)
- Kamada, N., "Unique CD14 intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23", IFN-gamma axis, 2008, pp.118, 2269~2280
- Ahern, P. P., "Interleukin-23 drives intestinal inflammation through direct activity on T cells", Immunity, 33, pp.279~288 (2010)
- Kamada, N., "Human CD14＋ macrophages in intestinal lamina propria exhibit potent antigen-presenting ability", J. Immunol, 183, pp.1724~1731 (2009)
- Lee, Y. K., "Late developmental plasticity in the T helper 17 lineage", Immunity, 30, pp.92~107 (2009)
- Ogino, T., "Increased Th17-Inducing Activity of CD14＋ CD163low Myeloid Cells in Intestinal Lamina Propria of Patients with Crohn's Disease", Gastroenterology, 145, pp.1380~1391 (2013)
- Uhlig, H. H., "Characterization of Foxp3＋CD4＋CD25＋ and IL-10-secreting CD4＋CD25＋ T cells during cure of colitis", J. Immunol, 177, pp.5852~5860 (2006)