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Efficacy of ramosetron in combination with polyethylene glycol of preparing for a colonoscopy

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Background: Because of its efficacy and safety, polyethylene glycol (PEG) is generally used to prepare for colonoscopy. However, the side effects of PEG, including nausea, vomiting, abdominal discomfort, pain, and general weakness, tend to decrease patient compliance and satisfaction. The aim of this study is to investigate the efficacy and safety of PEG with 0.1 mg ramosetron on colonoscopy patients who had difficulty taking PEG due to side effects or large volume. Methods: From January to August in 2012, 28 patients who visited Yeungnam University hospital for a colonoscopy were prospectively enrolled. All enrolled patients were previous history underwent colonoscopy using PEG only in our hospital. The efficacy and safety of ramosetron were assessed through the use of a questionnaire, and compared previous bowel preparation. Results: Compared to previous examination, the patients using the ramosetron reported less nausea, vomiting, abdominal discomfort, and abdominal pain, as well as a higher degree of compliance and satisfaction of the patient. There were no side effects reported with the use of ramosetron. However, overall bowel preparation quality was not better than the previous examination. Conclusion: In case of the use of ramosetron in combination with PEG for bowel preparation, patients experienced a higher rate of compliance and tolerance. Looking forward, ramosetron may become an option of pretreatment for bowel preparation.

Abstract

Background: Because of its efficacy and safety, polyethylene glycol (PEG) is generally used to prepare for colonoscopy. However, the side effects of PEG, including nausea, vomiting, abdominal discomfort, pain, and general weakness, tend to decrease patient compliance and satisfaction. The aim of this study is to investigate the efficacy and safety of PEG with 0.1 mg ramosetron on colonoscopy patients who had difficulty taking PEG due to side effects or large volume. Methods: From January to August in 2012, 28 patients who visited Yeungnam University hospital for a colonoscopy were prospectively enrolled. All enrolled patients were previous history underwent colonoscopy using PEG only in our hospital. The efficacy and safety of ramosetron were assessed through the use of a questionnaire, and compared previous bowel preparation. Results: Compared to previous examination, the patients using the ramosetron reported less nausea, vomiting, abdominal discomfort, and abdominal pain, as well as a higher degree of compliance and satisfaction of the patient. There were no side effects reported with the use of ramosetron. However, overall bowel preparation quality was not better than the previous examination. Conclusion: In case of the use of ramosetron in combination with PEG for bowel preparation, patients experienced a higher rate of compliance and tolerance. Looking forward, ramosetron may become an option of pretreatment for bowel preparation.

참고문헌 (32)

  1. Regula J, "Colonoscopy in colorectal-cancer screening for detection of advanced neoplasia", N Engl J Med, 355, pp.1863~1872 (2006)
  2. Piscatelli N, "Localizing colorectal cancer by colonoscopy", Arch Surg, 140, pp.932~935 (2005)
  3. Sonnenberg A, "Cost-effectiveness of a single colonoscopy in screening for colorectal cancer", Arch Intern Med, 162, pp.163~168 (2002)
  4. Heitman SJ, "Cost-effectiveness of computerized tomographic colonography versus colonoscopy for colorectal cancer screening", CMAJ, 173, pp.877~881 (2005)
  5. Wexner SD, "A consensus document on bowel preparation before colonoscopy: prepared by a task force from the American Society of Colon and Rectal Surgeons (ASCRS), the American Society for Gastrointestinal Endoscopy (ASGE), and the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES)", Gastrointest Endosc, 63, pp.894~909 (2006)
  6. Rex DK, "Quality in the technical performance of colonoscopy and the continuous quality improvement process for colonoscopy: recommendations of the U.S. Multi-Society Task Force on Colorectal Cancer", Am J Gastroenterol, 97, pp.1296~1308 (2002)
  7. Harewood GC, "Impact of colonoscopy preparation quality on detection of suspected colonic neoplasia", Gastrointest Endosc, 58, pp.76~79 (2003)
  8. Chokshi RV, "Prevalence of missed adenomas in patients with inadequate bowel preparation on screening colonoscopy", Gastrointest Endosc, 75, pp.1197~1203 (2012)
  9. Parra-Blanco A, "The timing of bowel preparation before colonoscopy determines the quality of cleansing, and is a significant factor contributing to the detection of flat lesions: a randomized study", World J Gastroenterol, 12, pp.6161~6166 (2006)
  10. Chiu HM, "Different bowel preparation schedule leads to different diagnostic yield of proximal and nonpolypoid colorectal neoplasm at screening colonoscopy in average-risk population", Dis Colon Rectum, 54, pp.1570~1577 (2011)
  11. Sharara AI, "The modern bowel preparation in colonoscopy", Gastroenterol Clin North Am, 42, pp.577~598 (2013)
  12. Jones RM, "Patient-reported barriers to colorectal cancer screening: a mixed-methods analysis", Am J Prev Med, 38, pp.508~516 (2010)
  13. Jover R, "Modifiable endoscopic factors that influence the adenoma detection rate in colorectal cancer screening colonoscopies", Gastrointest Endosc, 77, pp.381~389 (2013)
  14. Burke CA, "Enhancing the quality of colonoscopy: the importance of bowel purgatives", Gastrointest Endosc, 66, pp.565~573 (2007)
  15. "ASHP therapeutic guidelines on the pharmacologic management of nausea and vomiting in adult and pediatric patients receiving chemotherapy or radiation therapy or undergoing surgery", Am J Health Syst Pharm, 56, pp.729~764 (1999)
  16. Gan TJ, "Consensus guidelines for the management of postoperative nausea and vomiting", Anesth Analg, 118, pp.85~113 (2014)
  17. Chan CH, "Randomized single-blind clinical trial of a rapid colonic lavage solution (Golytely) vs. standard preparation for barium enema and colonoscopy", Gastrointest Radiol, 10, pp.378~382 (1985)
  18. Burke DA, "Oral bowel lavage preparation for colonoscopy", Postgrad Med J, 64, pp.772~774 (1988)
  19. Adler M, "Whole gut lavage for colonoscopy--a comparison between two solutions", Gastrointest Endosc, 30, pp.65~67 (1984)
  20. Beck DE, "Comparison of oral lavage methods for preoperative colonic cleansing", Dis Colon Rectum, 29, pp.699~703 (1986)
  21. Marshall JB, "Prospective, randomized trial comparing sodium phosphate solution with polyethylene glycol-electrolyte lavage for colonoscopy preparation", Gastrointest Endosc, 39, pp.631~634 (1993)
  22. Abdullah M, "A randomized, controlled, double-blind trial of the adjunct use of Clebopride in polyethylene glycol electrolyte (PEG) solution for colonoscopy preparation", Acta Med Indones, 42, pp.27~30 (2010)
  23. Tajika M, "Efficacy of mosapride citrate with polyethylene glycol solution for colonoscopy preparation", World J Gastroenterol, 18, pp.2517~2525 (2012)
  24. Rabasseda X, "Ramosetron, a 5-HT3 receptor antagonist for the control of nausea and vomiting", Drugs Today (Barc), 38, pp.75~89 (2002)
  25. 김원옥, "Ramosetron for the prevention of postoperative nausea and vomiting (PONV): a meta-analysis", Korean Journal of Anesthesiology, 61(5), pp.405~412 (2011), 대한마취통증의학회
  26. Ohta M, "Novel 5-hydroxytryptamine (5-HT3) receptor antagonists. III. Pharmacological evaluations and molecular modeling studies of optically active 4,5,6,7-tetrahydro-1H-benzimidazole derivatives", Chem Pharm Bull (Tokyo), 44, pp.1707~1716 (1996)
  27. Kim KR, "A randomized, double-blind pilot study of dose comparison of ramosetron to prevent chemotherapy-induced nausea and vomiting", Biomed Res Int, 2015, pp.523601~ (2015)
  28. Rostom A, "A randomized prospective trial comparing different regimens of oral sodium phosphate and polyethylene glycol-based lavage solution in the preparation of patients for colonoscopy", Gastrointest Endosc, 64, pp.544~552 (2006)
  29. Brady CE 3rd, "Golytely lavage--is metoclopramide necessary?", Am J Gastroenterol, 80, pp.180~184 (1985)
  30. Rhodes JB, "Metoclopramide reduces the distress associated with colon cleansing by an oral electrolyte overload", Gastrointest Endosc, 24, pp.162~163 (1978)
  31. Froehlich F, "Low sodium solution for colonic cleansing: a double-blind, controlled, randomized prospective study", Gastrointest Endosc, 38, pp.579~581 (1992)
  32. Huppertz-Hauss G, "Polyethylene glycol versus sodium phosphate in bowel cleansing for colonoscopy: a randomized trial", Endoscopy, 37, pp.537~541 (2005)

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