본문 바로가기
KERD
논문KCI 등재

기도 분비세포에서 점액의 세포외유출 조절

Regulation of Mucin Exocytosis in Airway Secretory Cells

0

조회

0

다운로드

0

인용

0

참고문헌

키워드

주제분류이비인후과학

초록

Mucin secretion in the airway epithelium acts as an essential barrier process that protects the upper respiratory tract from inhaled particles, environmental pathogens and toxicants. However, dysregulated mucin secretion contributes to pathophysiologic conditions such as rhinitis, asthma, and chronic obstructive pulmonary disease etc. The study on mucin hypersecretion has long been worked, but the exact molecular composition and mechanism for exocytic machinery remain mostly to be elucidated. The regulated mucin secretion, highly coordinated process, is mediated by the cooperative interaction of several proteins existing in the secretory granule, cytoplasm, and plasma membrane. This review provides the information on molecular components of the core exocytic machinery and their functional roles for mucin exocytosis in airway secretory cells.

Abstract

Mucin secretion in the airway epithelium acts as an essential barrier process that protects the upper respiratory tract from inhaled particles, environmental pathogens and toxicants. However, dysregulated mucin secretion contributes to pathophysiologic conditions such as rhinitis, asthma, and chronic obstructive pulmonary disease etc. The study on mucin hypersecretion has long been worked, but the exact molecular composition and mechanism for exocytic machinery remain mostly to be elucidated. The regulated mucin secretion, highly coordinated process, is mediated by the cooperative interaction of several proteins existing in the secretory granule, cytoplasm, and plasma membrane. This review provides the information on molecular components of the core exocytic machinery and their functional roles for mucin exocytosis in airway secretory cells.

참고문헌 (40)

  1. De Matteis MA, "Mendelian disorders of membrane trafficking", N Engl J Med, 365(10), pp.927~938 (2011)
  2. Martens S, "Mechanisms of membrane fusion: disparate players and common principles", Nat Rev Mol Cell Biol, 9(7), pp.543~556 (2008)
  3. Fahy JV, "Airway mucus function and dysfunction", N Engl J Med, 363(23), pp.2233~2247 (2010)
  4. Evans CM, "Mucin is produced by clara cells in the proximal airways of antigen-challenged mice", Am J Respir Cell Mol Biol, 31(4), pp.382~394 (2004)
  5. Williams IP, "Analyses of human tracheobronchial mucus from healthy subjects", Eur J Respir Dis, 63(6), pp.510~515 (1982)
  6. Boers JE, "Number and proliferation of clara cells in normal human airway epithelium", Am J Respir Crit Care Med, 159(5 Pt 1), pp.1585~1591 (1999)
  7. Rogers DF, "The airway goblet cell", Int J Biochem Cell Biol, 35(1), pp.1~6 (2003)
  8. Piccotti L, "Assessment of intracellular mucin content in vivo", Methods Mol Biol, 842, pp.279~295 (2012)
  9. Williams OW, "Am J Respir Cell Mol Biol", Am J Respir Cell Mol Biol, 34(5), pp.527~536 (2006)
  10. Davis CW, "Regulated airway goblet cell mucin secretion", Annu Rev Physiol, 70, pp.487~512 (2008)
  11. Gundelfinger ED, "Temporal and spatial coordination of exocytosis and endocytosis", Nat Rev Mol Cell Biol, 4(2), pp.127~139 (2003)
  12. Evans CM, "Airway mucus: the good, the bad, the sticky", Pharmacol Ther, 121(3), pp.332~348 (2009)
  13. Südhof TC, "The synaptic vesicle cycle: a cascade of protein-protein interactions", Nature, 375(6533), pp.645~653 (1995)
  14. Hussain S, "The discovery of the soluble N-ethylmaleimidesensitive factor attachment protein receptor complex and the molecular regulation of synaptic vesicle transmitter release: the 2010 Kavli Prize in neuroscience", Neuroscience, 190, pp.12~20 (2011)
  15. Kreda SM, "Receptor-promoted exocytosis of airway epithelial mucin granules containing a spectrum of adenine nucleotides", J Physiol, 588(Pt 12), pp.2255~2267 (2010)
  16. Tuvim MJ, "Synaptotagmin 2 couples mucin granule exocytosis to Ca2+ signaling from endoplasmic reticulum", J Biol Chem, 284(15), pp.9781~9787 (2009)
  17. Söllner T, "SNAP receptors implicated in vesicle targeting and fusion", Nature, 362(6418), pp.318~324 (1993)
  18. Rothman JE, "Mechanisms of intracellular protein transport", Nature, 372(6501), pp.55~63 (1994)
  19. Ferro-Novick S, "Vesicle fusion from yeast to man", Nature, 370(6486), pp.191~193 (1994)
  20. Brunger AT, "Structure and function of SNARE and SNAREinteracting proteins", Q Rev Biophys, 38(1), pp.1~47 (2005)
  21. Young SM Jr, "Synaptotagmin has an essential function in synaptic vesicle positioning for synchronous release in addition to its role as a calcium sensor", Neuron, 63(4), pp.482~496 (2009)
  22. Kochubey O, "Regulation of transmitter release by Ca(2+) and synaptotagmin: insights from a large CNS synapse", Trends Neurosci, 34(5), pp.237~246 (2011)
  23. Morgan A, "Common mechanisms for regulated exocytosis in the chromaffin cell and the synapse", Semin Cell Dev Biol, 8(2), pp.141~149 (1997)
  24. Pang ZP, "Synaptotagmin-2 is essential for survival and contributes to Ca2+ triggering of neurotransmitter release in central and neuromuscular synapses", J Neurosci, 26(52), pp.13493~13504 (2006)
  25. Zhu Y, "Munc13-2-", - baseline secretion defect reveals source of oligomeric mucins in mouse airways, 2008, pp.586(7), 1977~1992
  26. Kim K, "Munc18b is an essential gene in mice whose expression is limiting for secretion by airway epithelial and mast cells", Biochem J, 446(3), pp.383~394 (2012)
  27. Hay JC, "SNAREs and NSF in targeted membrane fusion", Curr Opin Cell Biol, 9(4), pp.505~512 (1997)
  28. Bock JB, "Protein transport. A fusion of new ideas", Nature, 387(6629), pp.133~135 (1997)
  29. Hanson PI, "Neurotransmitter release-four years of SNARE complexes", Curr Opin Neurobiol, 7(3), pp.310~315 (1997)
  30. Behrendorff N, "Vesicleassociated membrane protein 8 (VAMP8) is a SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) selectively required for sequential granule-to-granule fusion", J Biol Chem, 286(34), pp.29627~29634 (2011)
  31. Jones LC, "VAMP8 is a vesicle SNARE that regulates mucin secretion in airway goblet cells", J Physiol, 590(Pt 3), pp.545~562 (2012)
  32. Groffen AJ, "Doc2b is a high-affinity Ca2+ sensor for spontaneous neurotransmitter release", Science, 327(5973), pp.1614~1618 (2010)
  33. Regazzi R, "Molecular mechanisms of exocytosis" (2007), Landers Bioscience and Springer Science+Business Media
  34. Jahn R, "Membrane fusion and exocytosis", Annu Rev Biochem, 68, pp.863~911 (1999)
  35. Stojilkovic SS, "Ca2+-regulated exocytosis and SNARE function", Trends Endocrinol Metab, 16(3), pp.81~83 (2005)
  36. Jung SR, "Control of granule mobility and exocytosis by Ca2+ -dependent formation of F-actin in pancreatic duct epithelial cells", Traffic, 10(4), pp.392~410 (2009)
  37. Martin TF, "Stages of regulated exocytosis", Trends Cell Biol, 7(7), pp.271~276 (1997)
  38. Rogers DF, "Physiology of airway mucus secretion and pathophysiology of hypersecretion", Respir Care, 52(9), pp.1134~1146 (2007)
  39. Rogers DF, "Airway mucus hypersecretion in asthma: an undervalued pathology?", Curr Opin Pharmacol, 4(3), pp.241~250 (2004)
  40. Evans CM, "Mucus hypersecretion in asthma: causes and effects", Curr Opin Pulm Med, 15(1), pp.4~11 (2009)

관련 논문AI추천

이 간행물의 다른 논문 (3건)