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천식의 기도 염증과 개형 발생에서 기도상피세포의 역할

Airway epithelial cells in airway inflammation and remodeling in asthma

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초록

Airway epithelial cells are the front-line barrier to outer world, and abnormal response to environmental agents can cause asthma. Large numbers of recent studies support the evidence that airway epithelial cells play a crucial role in the development of airway inflammation and remodeling. Defective barrier function of airway epithelium facilitates allergic sensitization and initiation of allergic inflammation. Airway epithelial cells contribute to the development of type 2 immune response by secreting key cytokines, such as interleukin (IL)-25, IL-33, and thymic stromal lymphopoietin and the interactions between various innate immune cells, including innate lymphoid cells, granulocytes, and macrophages. Furthermore, airway remodeling can be induced by epithelial cell-derived mediators even independently of airway inflammation. Aberrant repair of airway injury or distinct biophysical/biochemical characteristics of airway epithelial cells in asthmatics may be involved in the pathophysiologic mechanism of airway remodeling. Therapeutic approaches targeting airway epithelial cells are warranted.

Abstract

Airway epithelial cells are the front-line barrier to outer world, and abnormal response to environmental agents can cause asthma. Large numbers of recent studies support the evidence that airway epithelial cells play a crucial role in the development of airway inflammation and remodeling. Defective barrier function of airway epithelium facilitates allergic sensitization and initiation of allergic inflammation. Airway epithelial cells contribute to the development of type 2 immune response by secreting key cytokines, such as interleukin (IL)-25, IL-33, and thymic stromal lymphopoietin and the interactions between various innate immune cells, including innate lymphoid cells, granulocytes, and macrophages. Furthermore, airway remodeling can be induced by epithelial cell-derived mediators even independently of airway inflammation. Aberrant repair of airway injury or distinct biophysical/biochemical characteristics of airway epithelial cells in asthmatics may be involved in the pathophysiologic mechanism of airway remodeling. Therapeutic approaches targeting airway epithelial cells are warranted.

참고문헌 (112)

  1. Galli SJ, "IgE and mast cells in allergic disease", Nat Med, 18, pp.693~704 (2012)
  2. Holgate ST, "Innate and adaptive immune responses in asthma", Nat Med, 18, pp.673~683 (2012)
  3. Stephen T Holgate, "Mechanisms of Asthma and Implications for Its Prevention and Treatment: A Personal Journey", Allergy, Asthma & Immunology Research, 5(6), pp.343~347 (2013), 대한천식알레르기학회
  4. Holtzman MJ, "The role of airway epithelial cells and innate immune cells in chronic respiratory disease", Nat Rev Immunol, 14, pp.686~698 (2014)
  5. Gauthier M, "Evolving concepts of asthma", J Respir Crit Care Med, 192, pp.660~668 (2015)
  6. Fahy JV, "Type 2 inflammation in asthma: present in most, absent in many", Nat Rev Immunol, 15, pp.57~65 (2015)
  7. Hammad H, "Barrier epithelial cells and the control of type 2 immunity", Immunity, 43, pp.29~40 (2015)
  8. Whitsett JA, "Respiratory epithelial cells orchestrate pulmonary innate immunity", Nat Immunol, 16, pp.27~35 (2015)
  9. Lambrecht BN, "The airway epithelium in asthma", Nat Med, 18, pp.684~692 (2012)
  10. Loxham M, "Epithelial function and dysfunction in asthma", Clin Exp Allergy, 44, pp.1299~1313 (2014)
  11. Knight DA, "The airway epithelium: structural and functional properties in health and disease", Respirology, 8, pp.432~446 (2003)
  12. Ganesan S, "Barrier function of airway tract epithelium", Tissue Barriers, 1, pp.E24997~ (2013)
  13. Rogers DF, "The airway goblet cell", Int J Biochem Cell Biol, 35, pp.1~6 (2003)
  14. Hong KU, "Basal cells are a multipotent progenitor capable of renewing the bronchial epithelium", Am J Pathol, 164, pp.577~588 (2004)
  15. Rock JR, "Basal cells as stem cells of the mouse trachea and human airway epithelium", Proc Natl Acad Sci U S A, 106, pp.12771~12775 (2009)
  16. Reynolds SD, "Clara cell: progenitor for the bronchiolar epithelium", Int J Biochem Cell Biol, 42, pp.1~4 (2010)
  17. Grainge CL, "Epithelial injury and repair in airways diseases", Chest, 144, pp.1906~1912 (2013)
  18. Georas SN, "Epithelial barrier function: at the front line of asthma immunology and allergic airway inflammation", J Allergy Clin Immunol, 134, pp.509~520 (2014)
  19. Niessen CM, "Tight junctions", adherens junctions: basic structure and function, 2007, pp.127, 2525~2532
  20. Schneeberger EE, "The tight junction: a multifunctional complex", Am J Physiol Cell Physiol, 286, pp.C1213~C1228 (2004)
  21. Ivanov AI, "Dynamics and regulation of epithelial adherens junctions: recent discoveries and controversies", Int Rev Cell Mol Biol, 303, pp.27~99 (2013)
  22. Barczyk M, "Integrins", Cell Tissue Res, 339, pp.269~280 (2010)
  23. Green KJ, "Desmosomes and hemidesmosomes: structure and function of molecular components", FASEB J, 10, pp.871~881 (1996)
  24. Lillehoj EP, "Cellular and molecular biology of airway mucins", Int Rev Cell Mol Biol, 303, pp.139~202 (2013)
  25. Voynow JA, "Mucins, mucus, and sputum", Chest, 135, pp.505~512 (2009)
  26. Lai HY, "Mucus hypersecretion in asthma: intracellular signalling pathways as targets for pharmacotherapy", Curr Opin Allergy Clin Immunol, 10, pp.67~76 (2010)
  27. Parker D, "Innate immunity in the respiratory epithelium", Am J Respir Cell Mol Biol, 45, pp.189~201 (2011)
  28. Rahman I, "Oxidant and antioxidant balance in theairways and airway diseases", Eur J Pharmacol, 533, pp.222~239 (2006)
  29. Holgate ST, "The role of the airway epithelium and its interaction with environmental factors in asthma pathogenesis", Proc Am Thorac Soc, 6, pp.655~659 (2009)
  30. Cambi A, "Levels of complexity in pathogen recognition by C-type lectins", Curr Opin Immunol, 17, pp.345~351 (2005)
  31. Chen K, "The active contribution of Toll-like receptors to allergic airway inflammation", Int Immunopharmacol, 11, pp.1391~1398 (2011)
  32. Lan RS, "Role of protease-activated receptors in airway function: a target for therapeutic intervention?", Pharmacol Ther, 95, pp.239~257 (2002)
  33. Yoneyama M, "The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses", Nat Immunol, 5, pp.730~737 (2004)
  34. Kouzaki H, "The danger signal, extracellular ATP, is a sensor for an airborne allergen and triggers IL-33 release and innate Th2-type responses", J Immunol, 186, pp.4375~4387 (2011)
  35. Willart MA, "The danger within: endogenous danger signals, atopy and asthma", Clin Exp Allergy, 39, pp.12~19 (2009)
  36. Petecchia L, "Bronchial airway epithelial cell damage following exposure to cigarette smoke includes disassembly of tight junction components mediated by the extracellular signal-regulated kinase 1", 2 pathway, 2009, pp.135, 1502~1512
  37. Bayram H, "Effect of ozone and nitrogen dioxide on the permeability of bronchial epithelial cell cultures of non-asthmatic and asthmatic subjects", Clin Exp Allergy, 32, pp.1285~1292 (2002)
  38. Leino MS, "Barrier disrupting effects of alternaria alternata extract on bronchial epithelium from asthmatic donors", PLoS One, 8, pp.E71278~ (2013)
  39. Vinhas R, "Pollen proteases compromise the airway epithelial barrier through degradation of transmembrane adhesion proteins and lung bioactive peptides", Allergy, 66, pp.1088~1098 (2011)
  40. Sajjan U, "Rhinovirus disrupts the barrier function of polarized airway epithelial cells", Am J Respir Crit Care Med, 178, pp.1271~1281 (2008)
  41. Comstock AT, "Rhinovirus-induced barrier dysfunction in polarized airway epithelial cells is mediated by NADPH oxidase 1", J Virol, 85, pp.6795~6808 (2011)
  42. Rezaee F, "Sustained protein kinase D activation mediates respiratory syncytial virus-induced airway barrier disruption", J Virol, 87, pp.11088~11095 (2013)
  43. Wan H, "Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions", J Clin Invest, 104, pp.123~133 (1999)
  44. Saatian B, "Interleukin-4 and interleukin-13 cause barrier dysfunction in human airway epithelial cells", Tissue Barriers, 1, pp.E24333~ (2013)
  45. Coyne CB, "Regulation of airway tight junctions by proinflammatory cytokines", Mol Biol Cell, 13, pp.3218~3234 (2002)
  46. Hardyman MA, "TNF-α-mediated bronchial barrier disruption and regulation by src-family kinase activation", J Allergy Clin Immunol, 132, pp.665~675 (2013)
  47. Thyssen JP, "Causes of epidermal filaggrin reduction and their role in the pathogenesis of atopic dermatitis", J Allergy Clin Immunol, 134, pp.792~799 (2014)
  48. Xiao C, "Defective epithelial barrier function in asthma", J Allergy Clin Immunol, 128, pp.549~556 (2011)
  49. Ying S, "Lack of filaggrin expression in the human bronchial mucosa", J Allergy Clin Immunol, 118, pp.1386~1388 (2006)
  50. Marenholz I, "Filaggrin loss-of-function mutations predispose to phenotypes involved in the atopic march", J Allergy Clin Immunol, 118, pp.866~871 (2006)
  51. Palmer CN, "Filaggrin null mutations are associated with increased asthma severity in children and young adults", J Allergy Clin Immunol, 120, pp.64~68 (2007)
  52. Kabesch M, "Association between polymorphisms in serine protease inhibitor, kazal type 5 and asthma phenotypes in a large German population sample", Clin Exp Allergy, 34, pp.340~345 (2004)
  53. Walley AJ, "Gene polymorphism in Netherton and common atopic disease", Nat Genet, 29, pp.175~178 (2001)
  54. Walden M, "Biochemical features, molecular biology and clinical relevance of the human 15-domain serine proteinase inhibitor LEKTI", Biol Chem, 383, pp.1139~1141 (2002)
  55. Birben E, "The role of SPINK5 in asthma related physiological events in the airway epithelium", Respir Med, 106, pp.349~355 (2012)
  56. Nadeem A, "Airway and systemic oxidant-antioxidant dysregulation in asthma: a possible scenario of oxidants spill over from lung into blood", Pulm Pharmacol Ther, 29, pp.31~40 (2014)
  57. Piacentini S, "Glutathione S-transferase polymorphisms, asthma susceptibility and confounding variables: a meta-analysis", Mol Biol Rep, 40, pp.3299~3313 (2013)
  58. Wu W, "Glutathione-S-transferase M1 regulation of diesel exhaust particle-induced pro-inflammatory mediator expression in normal human bronchial epithelial cells", Part Fibre Toxicol, 9, pp.31~ (2012)
  59. Walter P, "The unfolded protein response: from stress pathway to homeostatic regulation", Science, 334, pp.1081~1086 (2011)
  60. 김소리, "Endoplasmic Reticulum Stress and the Related Signaling Networks in Severe Asthma", Allergy, Asthma & Immunology Research, 7(2), pp.106~117 (2015), 대한천식알레르기학회
  61. Moffatt MF, "Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma", Nature, 448, pp.470~473 (2007)
  62. Moffatt MF, "A large-scale, consortium-based genomewide association study of asthma", N Engl J Med, 363, pp.1211~1221 (2010)
  63. Cantero-Recasens G, "The asthma-associated ORMDL3 gene product regulates endoplasmic reticulum-mediated calcium signaling and cellular stress", Hum Mol Genet, 19, pp.111~121 (2010)
  64. Miller M, "ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, OAS, and ATF6", Proc Natl Acad Sci U S A, 109, pp.16648~16653 (2012)
  65. Gandhi VD, "Airway epithelium interactions with aeroallergens: role of secreted cytokines and chemokines in innate immunity", Front Immunol, 6, pp.147~ (2015)
  66. Lambrecht BN, "The immunology of asthma", Nat Immunol, 16, pp.45~56 (2015)
  67. Ho LH, "IL-33 induces IL-13 production by mouse mast cells independently of IgE-FcepsilonRI signals", J Leukoc Biol, 82, pp.1481~1490 (2007)
  68. Yu S, "Innate lymphoid cells and asthma", J Allergy Clin Immunol, 133, pp.943~950 (2014)
  69. Moro K, "Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells", Nature, 463, pp.540~544 (2010)
  70. Yasuda K, "Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice", Proc Natl Acad Sci U S A, 109, pp.3451~3456 (2012)
  71. Halim TY, "Lung natural helper cells are a critical source of Th2 cell-type cytokines in protease allergen-induced airway inflammation", Immunity, 36, pp.451~463 (2012)
  72. Kim HY, "Innate lymphoid cells responding to IL-33 mediate airway hyperreactivity independently of adaptive immunity", J Allergy Clin Immunol, 129, pp.216~227 (2012)
  73. Chang YJ, "Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity", Nat Immunol, 12, pp.631~638 (2011)
  74. Albacker LA, "Invariant natural killer T cells recognize a fungal glycosphingolipid that can induce airway hyperreactivity", Nat Med, 19, pp.1297~1304 (2013)
  75. Byers DE, "Alternatively activated macrophages and airway disease", Chest, 140, pp.768~774 (2011)
  76. Hunninghake GM, "TSLP polymorphisms are associated with asthma in a sex-specific fashion", Allergy, 65, pp.1566~1575 (2010)
  77. Bleck B, "MicroRNA-375 regulation of thymic stromal lymphopoietin by diesel exhaust particles and ambient particulate matter in human bronchial epithelial cells", J Immunol, 190, pp.3757~3763 (2013)
  78. Corne JM, "Frequency, severity, and duration of rhinovirus infections in asthmatic and non-asthmatic individuals: a longitudinal cohort study", Lancet, 359, pp.831~834 (2002)
  79. Wang Q, "Role of double-stranded RNA pattern recognition receptors in rhinovirus-induced airway epithelial cell responses", J Immunol, 183, pp.6989~6997 (2009)
  80. Contoli M, "Role of deficient type III interferon-lambda production in asthma exacerbations", Nat Med, 12, pp.1023~1026 (2006)
  81. Wark PA, "Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus", J Exp Med, 201, pp.937~947 (2005)
  82. Hirota N, "Mechanisms of airway remodeling", Chest, 144, pp.1026~1032 (2013)
  83. Park JA, "Putting the squeeze on airway epithelia", Physiology (Bethesda), 30, pp.293~303 (2015)
  84. Holgate ST, "Epithelial-mesenchymal interactions in the pathogenesis of asthma", J Allergy Clin Immunol, 105(2 Pt 1), pp.193~204 (2000)
  85. Crosby LM, "Epithelial repair mechanisms in the lung", Am J Physiol Lung Cell Mol Physiol, 298, pp.L715~L731 (2010)
  86. Davies DE, "The role of the epithelium in airway remodeling in asthma", Proc Am Thorac Soc, 6, pp.678~682 (2009)
  87. Tschumperlin DJ, "Mechanical stimuli to airway remodeling", Am J Respir Crit Care Med, 164(10 Pt 2), pp.S90~S94 (2001)
  88. Fedorov IA, "Epithelial stress and structural remodelling in childhood asthma", Thorax, 60, pp.389~394 (2005)
  89. Lopez-Guisa JM, "Airway epithelial cells from asthmatic children differentially express proremodeling factors", J Allergy Clin Immunol, 129, pp.990~997 (2012)
  90. Sidhu SS, "Roles of epithelial cell-derived periostin in TGF-beta activation, collagen production, and collagen gel elasticity in asthma", Proc Natl Acad Sci U S A, 107, pp.14170~14175 (2010)
  91. Stevens PT, "Dysregulated repair in asthmatic paediatric airway epithelial cells: the role of plasminogen activator inhibitor-1", Clin Exp Allergy, 38, pp.1901~1910 (2008)
  92. Kelly MM, "Epithelial expression of profibrotic mediators in a model of allergen-induced airway remodeling", Am J Respir Cell Mol Biol, 32, pp.99~107 (2005)
  93. Davies DE, "Airway remodeling in asthma: new insights", J Allergy Clin Immunol, 111, pp.215~225 (2003)
  94. Park JA, "Chronic intermittent mechanical stress increases MUC5AC protein expression", Am J Respir Cell Mol Biol, 41, pp.459~466 (2009)
  95. MA, "Mechanical stress is communicated between different cell types to elicit matrix remodeling", Proc Natl Acad Sci U S A, 98, pp.6180~6185 (2001)
  96. Tschumperlin DJ, "Mechanotransduction through growth-factor shedding into the extracellular space", Nature, 429, pp.83~86 (2004)
  97. Tschumperlin DJ, "Mechanical stress triggers selective release of fibrotic mediators from bronchial epithelium", Am J Respir Cell Mol Biol, 28, pp.142~149 (2003)
  98. Park JA, "Tissue factor-bearing exosome secretion from human mechanically stimulated bronchial epithelial cells in vitro and in vivo", J Allergy Clin Immunol, 130, pp.1375~1383 (2012)
  99. Jennifer A. Mitchel, "IL-13 Augments Compressive Stress–Induced Tissue Factor Expression in Human Airway Epithelial Cells", American Journal of Respiratory Cell and Molecular Biology, 54(4), pp.524~531 (2016), American Thoracic Society[DOI]
  100. Grainge CL, "Effect of bronchoconstriction on airway remodeling in asthma", N Engl J Med, 364, pp.2006~2015 (2011)
  101. Hackett TL, "Epithelial-mesenchymal transition in the pathophysiology of airway remodelling in asthma", Curr Opin Allergy Clin Immunol, 12, pp.53~59 (2012)
  102. Acloque H, "Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease", J Clin Invest, 119, pp.1438~1449 (2009)
  103. Gomes LR, "Epithelial-mesenchymal transition: implications in cancer progression and metastasis", Curr Pharm Biotechnol, 12, pp.1881~1890 (2011)
  104. Doerner AM, "TGF-beta1 induced epithelial to mesenchymal transition (EMT) in human bronchial epithelial cells is enhanced by IL-1beta but not abrogated by corticosteroids", Respir Res, 10, pp.100~ (2009)
  105. Hackett TL, "Induction of epithelial-mesenchymal transition in primary airway epithelial cells from patients with asthma by transforming growth factor-beta1", Am J Respir Crit Care Med, 180, pp.122~133 (2009)
  106. Zhang M, "TGF-beta1 induces human bronchial epithelial cell-to-mesenchymal transition in vitro", Lung, 187, pp.187~194 (2009)
  107. Zhou BP, "Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition", Nat Cell Biol, 6, pp.931~940 (2004)
  108. Heijink IH, "House dust mite-promoted epithelial-to-mesenchymal transition in human bronchial epithelium", Am J Respir Cell Mol Biol, 42, pp.69~79 (2010)
  109. Swarr DT, "Curr Opin Allergy Clin Immunol", Curr Opin Allergy Clin Immunol, 10, pp.434~442 (2010)
  110. Hackett TL, "Intrinsic phenotypic differences of asthmatic epithelium and its inflammatory responses to respiratory syncytial virus and air pollution", Am J Respir Cell Mol Biol, 45, pp.1090~1100 (2011)
  111. Wu H, "Genetic variation in ORM1-like 3 (ORMDL3) and gasdermin-like (GSDML) and childhood asthma", Allergy, 64, pp.629~635 (2009)
  112. Park JA, "Unjamming and cell shape in the asthmatic airway epithelium", Nat Mater, 14, pp.1040~1048 (2015)

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