경구강 수술 후 재발한 구인두암 환자에서 성공적인 구제치료를 위한 예후인자
Salvage Therapy and Prognostic Factors of Recurrent Oropharyngeal Cancer After Transoral Surgery
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Background and Objectives We analyzed the data of oropharyngeal squamous cell carcinoma(OPSCC) patients who had transoral surgery with/without adjuvant therapy and experiencedrecurrence. From the data, the treatment outcomes and prognostic factors of recurrentOPSCC were evaluated, and the predictive factors related to successful salvage treatmentwere identified. Subjects and Method We used data from patients who were diagnosed with OPSCC andreceived transoral surgery at the hospital from January 2005 to December 2019. Results The 5-year survival rate of patients with recurrent OPSCC was 43.9%. The predictorsof successful salvage treatment were adjuvant therapy and the p16 status. The 5-year survivalrate following salvage treatment for patients who had recurrent OPSCC and also testedp16-positive was 64%; however, it was only 30% for patients who had recurrent OPSCC andtested p16-negative. The 5-year survival rate was 22% for patients who received adjuvant therapyand 64% for those who did not receive it. Conclusion In OPSCC patients who recurred after transoral surgery with/without adjuvanttherapy, the salvage treatment success rate was 45%. In recurrent cancer, the HPV status wasan important factor associated with successful salvage treatment, as the success rate of salvagetreatment was remarkably high in patients who did not receive adjuvant therapy. Thus, we verifiedthat it is crucial to conduct an initial surgery with clear margins and determine the optimalcriteria for adjuvant therapy.
Abstract
Background and Objectives We analyzed the data of oropharyngeal squamous cell carcinoma(OPSCC) patients who had transoral surgery with/without adjuvant therapy and experiencedrecurrence. From the data, the treatment outcomes and prognostic factors of recurrentOPSCC were evaluated, and the predictive factors related to successful salvage treatmentwere identified. Subjects and Method We used data from patients who were diagnosed with OPSCC andreceived transoral surgery at the hospital from January 2005 to December 2019. Results The 5-year survival rate of patients with recurrent OPSCC was 43.9%. The predictorsof successful salvage treatment were adjuvant therapy and the p16 status. The 5-year survivalrate following salvage treatment for patients who had recurrent OPSCC and also testedp16-positive was 64%; however, it was only 30% for patients who had recurrent OPSCC andtested p16-negative. The 5-year survival rate was 22% for patients who received adjuvant therapyand 64% for those who did not receive it. Conclusion In OPSCC patients who recurred after transoral surgery with/without adjuvanttherapy, the salvage treatment success rate was 45%. In recurrent cancer, the HPV status wasan important factor associated with successful salvage treatment, as the success rate of salvagetreatment was remarkably high in patients who did not receive adjuvant therapy. Thus, we verifiedthat it is crucial to conduct an initial surgery with clear margins and determine the optimalcriteria for adjuvant therapy.
참고문헌 (10)
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