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국소 재발한 두경부암의 치료

Treatment for Locoregionally Recurrent Head and Neck Cancers

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주제분류이비인후과학

초록

The locoregional recurrence rate after treatment of head and neck cancer (HNC) is known tobe about 40%, and recurrence of cancer is the major factor directly related to the survival ofpatients. Recurrent HNC has different biological characteristics and tumor microenvironmentfrom those of index cancer. And it subsequently exhibits pro-tumoral and treatment-resistanttraits, which leads to difficulties in selecting salvage treatments and followed by dismal prognosis. Furthermore, since which salvage treatment can be selected and what the result of itwill be determined by the prior treatment, there should be careful consideration in the initialtherapeutic strategy. In this review, currently used treatment methods and results for locoregionallyrecurrent HNC are summarized, and considerations for each treatment based on theclinical and biomolecular characteristics of recurrent HNC are discussed. In addition, this reviewcontains introductions of new therapeutic strategies including recent clinical trials and aperspective on the future direction for treatment of locoregionally recurrent HNC.

Abstract

The locoregional recurrence rate after treatment of head and neck cancer (HNC) is known tobe about 40%, and recurrence of cancer is the major factor directly related to the survival ofpatients. Recurrent HNC has different biological characteristics and tumor microenvironmentfrom those of index cancer. And it subsequently exhibits pro-tumoral and treatment-resistanttraits, which leads to difficulties in selecting salvage treatments and followed by dismal prognosis. Furthermore, since which salvage treatment can be selected and what the result of itwill be determined by the prior treatment, there should be careful consideration in the initialtherapeutic strategy. In this review, currently used treatment methods and results for locoregionallyrecurrent HNC are summarized, and considerations for each treatment based on theclinical and biomolecular characteristics of recurrent HNC are discussed. In addition, this reviewcontains introductions of new therapeutic strategies including recent clinical trials and aperspective on the future direction for treatment of locoregionally recurrent HNC.

참고문헌 (58)

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경구강 수술 후 재발한 구인두암 환자에서 성공적인 구제치료를 위한 예후인자고윤우, 곽문수, 김대현, 김세헌, 박영민, 임재열대한이비인후과학회 · 대한이비인후과학회지 두경부외과학2024 · 제67권 제12호두경부암종의 경부재발 치료 성적에 영향을 미치는 인자권성근, 권택균, 김광현, 김상욱, 성명훈, 정영호, 정우진, 하정훈대한이비인후과학회 · 대한이비인후과학회지 두경부외과학2006 · 제49권 제8호Intensity-Modulated Radiotherapy-Based Reirradiation for Head and Neck Cancer: A Multi-institutional Study by Korean Radiation Oncology Group (KROG 1707)김명수, 김성현, 김연실, 김태형, 김현주, 박재원, 이정심, 이창걸대한암학회 · Cancer Research and Treatment2020 · 제52권 제4호두경부암의 방사선 저항성 기전 및 극복방안 연구한명월대한이비인후과학회 · 대한이비인후과학회지 두경부외과학2023 · 제66권 제5호Outcomes of Salvage Therapy for Oropharyngeal Cancer Recurrence Following Upfront Radiation Therapy and Prognostic Factors김태환, 김학정, 김희정, 백정환, 손영익, 안용찬, 오동렬, 이희준, 정만기, 정한신, 최나연대한암학회 · Cancer Research and Treatment2023 · 제55권 제4호Radioresistance Mechanisms in Head and Neck Cancer구본석, Quoc Khanh Nguyen대한이비인후과학회 · Clinical and Experimental Otorhinolaryngology2025 · 제18권 제3호

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