구인두암에서 초치료에 따른 생존 분석
Primary Treatment and Survival Outcomes in Oropharyngeal Cancer
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Background and Objectives Oropharyngeal cancer is one of those cancers with increasingincidence, and the therapeutic choices remain controversial. This study aims to evaluate the influenceof changes in the primary treatment on the prognosis of oropharyngeal cancer patients. Subjects and Method A total of 135 patients treated for oropharyngeal cancer in a singleinstitution from 2004 to 2017 were analyzed in this study. Disease-free survival rate and the 3-,5-year survival rates were calculated according to various radical primary treatments, whichincluded concurrent chemo-radiation or radiation therapy, and surgery. Other outcomes includingfunctional outcomes and treatment duration were also reported. Results The proportion of patients who were no-evidence-of-disease state at the last followup was 97.8% for the group who underwent surgery as radical primary treatment, followed byconcurrent chemo-radiation or radiation therapy (84.1%). The five-year survival rate was 0.7963[95% confidence interval (CI): 0.6746-0.8765] for the concurrent chemo-radiation or radiationtherapy group and 0.9488 (95% CI: 0.8093-0.9870) for the surgery group. When surgerywas chosen as radical primary treatment for appropriately selected patients, approximately30% of the patients could avoid radiation therapy. Gastrostomy or admission for supportive careas functional outcome showed no significant difference between treatment groups. Conclusion Our results show various treatment outcomes depending on the radical primarytreatment. These results can be used in clinical decisions and patient counselling.
Abstract
Background and Objectives Oropharyngeal cancer is one of those cancers with increasingincidence, and the therapeutic choices remain controversial. This study aims to evaluate the influenceof changes in the primary treatment on the prognosis of oropharyngeal cancer patients. Subjects and Method A total of 135 patients treated for oropharyngeal cancer in a singleinstitution from 2004 to 2017 were analyzed in this study. Disease-free survival rate and the 3-,5-year survival rates were calculated according to various radical primary treatments, whichincluded concurrent chemo-radiation or radiation therapy, and surgery. Other outcomes includingfunctional outcomes and treatment duration were also reported. Results The proportion of patients who were no-evidence-of-disease state at the last followup was 97.8% for the group who underwent surgery as radical primary treatment, followed byconcurrent chemo-radiation or radiation therapy (84.1%). The five-year survival rate was 0.7963[95% confidence interval (CI): 0.6746-0.8765] for the concurrent chemo-radiation or radiationtherapy group and 0.9488 (95% CI: 0.8093-0.9870) for the surgery group. When surgerywas chosen as radical primary treatment for appropriately selected patients, approximately30% of the patients could avoid radiation therapy. Gastrostomy or admission for supportive careas functional outcome showed no significant difference between treatment groups. Conclusion Our results show various treatment outcomes depending on the radical primarytreatment. These results can be used in clinical decisions and patient counselling.
참고문헌 (27)
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