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No Effect on Body Dissatisfaction of an Interaction between 5-HTTLPR Genotype and Neuroticism in a Young Adult Korean Population

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Objective: Many studies suggest an association between the serotonin transporter gene-linked polymorphic region (5-HTTLPR)and anxiety-related personality traits (e.g., neuroticism) in healthy subjects. This study investigated the interaction of 5-HTTLPRgenotype on body dissatisfaction by neuroticism and to evaluate the interaction of 5-HTTLPR genotype on self-esteem by bodydissatisfaction in a young adult Korean population. Methods: Two hundred and eighty three subjects were included in this study. The Eysenck Personality Questionnaire-Koreanversion was used to evaluate neuroticism, the Body Dysmorphic Disorder Examination-Self Report (BDDE-SR)-Korean versionwas used to evaluate body dissatisfaction, and the Self-Esteem Scale (SES)-Korean version was used to evaluate self-esteem. The 5-HTTLPR genotype by neuroticism (high : low) interaction was assessed according to the total BDDE-SR score, and5-HTTLPR genotype by BDDE-SR (high : low) interaction was assessed according to the total SES score. Results: The analysis of 5-HTTLPR genotype and neuroticism (high : low) with respect to body dissatisfaction showed no maineffects of genotype whereas neuroticism did influence the BDDE-SR score and no interaction of the genotype with neuroticism. The analysis of 5-HTTLPR genotype and BDDE-SR (high : low) with respect to self-esteem score showed no main effects ofgenotype whereas BDDE-SR did influence the self-esteem score and no interaction of the genotype with body dissatisfaction. Conclusion: These results suggest that an interaction between 5-HTTPLR genotype and neuroticism does not affect body dissatisfactionand an interaction between 5-HTTPLR genotype and body dissatisfaction does not affect self-esteem in a young adultKorean population.

Abstract

Objective: Many studies suggest an association between the serotonin transporter gene-linked polymorphic region (5-HTTLPR)and anxiety-related personality traits (e.g., neuroticism) in healthy subjects. This study investigated the interaction of 5-HTTLPRgenotype on body dissatisfaction by neuroticism and to evaluate the interaction of 5-HTTLPR genotype on self-esteem by bodydissatisfaction in a young adult Korean population. Methods: Two hundred and eighty three subjects were included in this study. The Eysenck Personality Questionnaire-Koreanversion was used to evaluate neuroticism, the Body Dysmorphic Disorder Examination-Self Report (BDDE-SR)-Korean versionwas used to evaluate body dissatisfaction, and the Self-Esteem Scale (SES)-Korean version was used to evaluate self-esteem. The 5-HTTLPR genotype by neuroticism (high : low) interaction was assessed according to the total BDDE-SR score, and5-HTTLPR genotype by BDDE-SR (high : low) interaction was assessed according to the total SES score. Results: The analysis of 5-HTTLPR genotype and neuroticism (high : low) with respect to body dissatisfaction showed no maineffects of genotype whereas neuroticism did influence the BDDE-SR score and no interaction of the genotype with neuroticism. The analysis of 5-HTTLPR genotype and BDDE-SR (high : low) with respect to self-esteem score showed no main effects ofgenotype whereas BDDE-SR did influence the self-esteem score and no interaction of the genotype with body dissatisfaction. Conclusion: These results suggest that an interaction between 5-HTTPLR genotype and neuroticism does not affect body dissatisfactionand an interaction between 5-HTTPLR genotype and body dissatisfaction does not affect self-esteem in a young adultKorean population.

참고문헌 (40)

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