한국 여성에서 5-HTTLPR 유전자 다형성과 성격특성의 연관성
Serotonin transporter-linked promoter region polymorphism and personality traits in a Korean female population
1
조회
0
다운로드
1
인용
0
참고문헌
초록
Abstract
Objectives : Findings from behavioral genetics which demonstrate the high heritability of personality traits have stimulated the search for the specific genes underlying personality. A large number of association studies have investigated a correlation between serotonin transporter-linked promoter region (5-HTTLPR) polymorphism and personality traits but the results have been inconsistent. So, the aim of this study is to investigate in a large sample with homogenous background about ethnicity, gender, occupation, and age. Method : The participants included 247 healthy Korean female adults(mean age=23.12, SD=3.22)with no history of psychiatric disorders and other physical illnesses. Genomic DNA was extracted from peripheral blood, and genotyping was performed by PCR. Personality assessment was done with the Temperament and Character Inventory (TCI).Results: Genotype Frequencies are l/l 3.6%, l/s 32.8% and s/s 63.6%( l allele: 20%, s allele: 80%). This low frequency of the l allele and l/l genotype was different from Caucasian results. No significant association was observed between 5-HTTLPR polymorphism and personality traits in a Korean female population.Conclusion: This study investigated the association between 5-HTTLPR polymorphism and personality traits in Korean female subjects, that is a large sample with homogenous background about ethnicity, gender, occupation, and age. No significant association was observed between 5-HTTLPR polymorphism and personality traits in a Korean female population.
참고문헌 (26)
- Costa PT Jr, "Stability and change in personality assessment: the revised NEO Personality Inventory in the year 2000.", 68, pp.86~94 (1997)
- Cloninger CR, "A systematic method for clinical description and classification of personality variants Archives of General Psychiatry 1987;44", pp.573~588
- Cloninger CR, "A psychobiological model of temperament and character", pp.975~990 (1993)
- Ebstein RP., "The molecular genetic architecture of human personality: beyond self-report questionnaires.", 11, pp.427~445 (2006)
- Lee HJ, "D2 and D4 dopamine receptor gene polymorphisms and personality traits in a young Korean population.", 121(1), pp.44~49 (2003)
- Ham BJ, "Serotonergic genes and personality traits in the Korean population.", 354(1), pp.2~5 (2004)
- Ha JH, "An association Study of the 5-HTTLPR and COMT Genes Polymorphisms and Personality traits. Kor Jr of Biological Psychiatry.", 11(2), pp.88~93 (2004)
- Kim SJ, "Association between Serotonin transporter Linked Promotor Region Polymorphism and Personality Taits-Normal Female Population Study.", 15(2), pp.206~210 (2004)
- Kim SJ, "Serotonin transporter gene polymorphism and personality traits in a Korean population.", 51, pp.243~247 (2005)
- Veenstra-VanderWeele J, "Pharmacogenetics and the serotonin system: initial studies and future directions.", 410(2-3), pp.165~181 (2000)
- Heils A, "Allelic variation of human serotonin transporter gene expression.", 66(6), pp.2621~2624 (1996)
- Greenberg B, "Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets.", 88, pp.83~87 (1999)
- =serotonin uptake study in Korean depressed patients., , 2002, 54~60
- Lesch KP, "Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region.", 274, pp.1527~1531 (1996)
- Munafo MR, "Genetic polymorphisms and personality in healthy adults: a systematic review and meta-analysis.", 8, pp.471~484 (2003)
- McQueen JK, "Estradiol-17 beta increases serotonin transporter (SERT) mRNA levels and the density of SERT-binding sites in female rat brain.", 43, pp.12~23 (1997)
- Sung SM, "Reliability and validity of the Korean version of the temperament and character inventory.", 43, pp.235~243 (2002)
- Umekage T, "Serotonin transporter-linked promoter region polymorphism and personality traits in a Japanese population.", pp.205~207 (2003)
- Kumakiri C, "Study of the association between the serotonin transporter gene regulatory region polymorphism and personality traits in a Japanese population.", 263, pp.205~207 (1999)
- Nakamura T, "Serotonin transporter gene regulatory region polymorphism and anxiety-related traits in Japanese.", 74, pp.544~545 (1997)
- Tsai S, "Serotonin Transpoter genetic polymorphisms and harm avoidance in Chinese.", 12, pp.165~168 (2002)
- Gelemter J, "Serotonin transporter protein (SLC6A4) allele and haplotype frequencies and linkage disequilibria in African- and Europian-American and Japanese populations and in alcohol-dependent subnects.", 101, pp.243~246 (1997)
- Nakamura M, "The human serotonin transporter gene linked polymorphism (5-HTTRPL) shows ten novel allelic variants.", 5, pp.32~38 (2000)
- De Luca V, "Association study between the novel functional polymorphism of the serotonin transporter gene and suicidal behaviour in schizophrenia.", 16(4), pp.268~271 (2006)
- Bouchard TJ Jr, "Genes, environment, and personality.", 264, pp.1700~1701 (1994)
- Joo YH, "No association between 5-HTTLPR and harm avoidance in Korean college students.", 22(1), pp.138~141 (2007)