Bilateral Repetitive Transcranial Magnetic Stimulation for Auditory Hallucinations in Patients with Schizophrenia: A Randomized Controlled, Cross-over Study
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Objective: A randomized double-blind cross-over trial was conducted in patients with persistent auditory hallucinations (AHs)to investigate whether bilateral repetitive transcranial magnetic stimulation (rTMS) at the temporoparietal area or Broca’s areais more effective at high- or low-frequencies compared to a sham condition. Methods: Twenty three patients with persistent AHs who remained stable on the same medication for 2 months were enrolled. They were randomized to one of four conditions: low-frequency (1 Hz)-rTMS to the temporoparietal area (L-TP), high-frequency(20 Hz)-rTMS to the temporoparietal area (H-TP), high-frequency (20 Hz)-rTMS to Broca’s area (H-B), or sham. Results: All the four rTMS conditions resulted in significant decrease in the scores under the auditory hallucination rating scaleand hallucination change scale over time. However, there were no significant treatment effects or interaction between time andtreatment, suggesting no superior effects of the new paradigms over the sham condition. Conclusion: Our findings suggest that bilateral rTMS at the temporoparietal area or Broca’s area with high- or low-frequencydoes not produce superior effects in reducing AHs compared to sham stimulation.
Abstract
Objective: A randomized double-blind cross-over trial was conducted in patients with persistent auditory hallucinations (AHs)to investigate whether bilateral repetitive transcranial magnetic stimulation (rTMS) at the temporoparietal area or Broca’s areais more effective at high- or low-frequencies compared to a sham condition. Methods: Twenty three patients with persistent AHs who remained stable on the same medication for 2 months were enrolled. They were randomized to one of four conditions: low-frequency (1 Hz)-rTMS to the temporoparietal area (L-TP), high-frequency(20 Hz)-rTMS to the temporoparietal area (H-TP), high-frequency (20 Hz)-rTMS to Broca’s area (H-B), or sham. Results: All the four rTMS conditions resulted in significant decrease in the scores under the auditory hallucination rating scaleand hallucination change scale over time. However, there were no significant treatment effects or interaction between time andtreatment, suggesting no superior effects of the new paradigms over the sham condition. Conclusion: Our findings suggest that bilateral rTMS at the temporoparietal area or Broca’s area with high- or low-frequencydoes not produce superior effects in reducing AHs compared to sham stimulation.
참고문헌 (49)
- American Psychiatric Association, "Task force on DSM-IV. Diagnostic and statistical manual of mental disorders:DSM-IV-TR" (2000), American Psychiatric Association
- Nayani TH, "The auditory hallucination: a phenomenological survey", Psychol Med, 26, pp.177~189 (1996)
- Carter DM, "Patients' strategies for coping with auditory hallucinations", J Nerv Ment Dis, 184, pp.159~164 (1996)
- Pantelis C, "Drug strategies and treatmentresistant schizophrenia", Aust N Z J Psychiatry, 30, pp.20~37 (1996)
- Breier A, "National Institute of Mental Health longitudinal study of chronic schizophrenia. Prognosis and predictors of outcome", Arch Gen Psychiatry, 48, pp.239~246 (1991)
- Harkavy-Friedman JM, "Suicide attempts in schizophrenia:the role of command auditory hallucinations for suicide", J Clin Psychiatry, 64, pp.871~874 (2003)
- 이승환, "치료저항성 환청을 지닌 정신분열병 환자의 임상특성 및 신경인지기능", 신경정신의학, 43(3), pp.288~295 (2004), 대한신경정신의학회
- Chen R, "Depression of motor cortex excitability by low-frequency transcranial magnetic stimulation", Neurology, 48, pp.1398~1403 (1997)
- Wassermann EM, "Therapeutic application of repetitive transcranial magnetic stimulation: a review", Clin Neurophysiol, 112, pp.1367~1377 (2001)
- Ziemann U, "Interaction between intracortical inhibition and facilitation in human motor cortex", J Physiol, 496, pp.873~881 (1996)
- Esser SK, "A direct demonstration of cortical LTP in humans: a combined TMS", EEG study, 2006, pp.69, 86~94
- Hoffman RE, "Transcranial magnetic stimulation of left temporoparietal cortex in three patients reporting hallucinated "voices"", Biol Psychiatry, 46, pp.130~132 (1999)
- Slotema CW, "Metaanalysis of repetitive transcranial magnetic stimulation in the treatment of auditory verbal hallucinations: update and effects after one month", Schizophr Res, 142, pp.40~45 (2012)
- Slotema CW, "Review of the efficacy of transcranial magnetic stimulation for auditory verbal hallucinations", Biol Psychiatry, 76, pp.101~110 (2014)
- Shergill SS, "Mapping auditory hallucinations in schizophrenia using functional magnetic resonance imaging", Arch Gen Psychiatry, 57, pp.1033~1038 (2000)
- Suzuki M, "Left superior temporal blood flow increases in schizophrenic and schizophreniform patients with auditory hallucination: a longitudinal case study using 123I-IMP SPECT", Eur Arch Psychiatry Clin Neurosci, 242, pp.257~261 (1993)
- Dierks T, "Activation of Heschl's gyrus during auditory hallucinations", Neuron, 22, pp.615~621 (1999)
- McGuire PK, "Increased blood flow in Broca's area during auditory hallucinations in schizophrenia", Lancet, 342, pp.703~706 (1993)
- Silbersweig DA, "A functional neuroanatomy of hallucinations in schizophrenia", Nature, 378, pp.176~179 (1995)
- van de Ven VG, "The spatiotemporal pattern of auditory cortical responses during verbal hallucinations", Neuroimage, 27, pp.644~655 (2005)
- Dollfus S, "Treatment of auditory hallucinations by combining high-frequency repetitive transcranial magnetic stimulation and functional magnetic resonance imaging", Schizophr Res, 102, pp.348~351 (2008)
- Montagne-Larmurier A, "Two-day treatment of auditory hallucinations by high frequency rTMS guided by cerebral imaging: a 6 month follow-up pilot study", Schizophr Res, 113, pp.77~83 (2009)
- Huang YZ, "Theta burst stimulation of the human motor cortex", Neuron, 45, pp.201~206 (2005)
- Kindler J, "Theta burst transcranial magnetic stimulation for the treatment of auditory verbal hallucinations: results of a randomized controlled study", Psychiatry Res, 209, pp.114~117 (2013)
- Kubera KM, "Source-based morphometry of gray matter volume in patients with schizophrenia who have persistent auditory verbal hallucinations", Prog Neuropsychopharmacol Biol Psychiatry, 50, pp.102~109 (2014)
- Oldfield RC., "The assessment and analysis of handedness:the Edinburgh inventory", Neuropsychologia, 9, pp.97~113 (1971)
- Schönfeldt-Lecuona C, "Stereotaxic rTMS for the treatment of auditory hallucinations in schizophrenia", Neuroreport, 15, pp.1669~1673 (2004)
- Loo CK, "A sham-controlled trial of left and right temporal rTMS for the treatment of auditory hallucinations", Psychol Med, 40, pp.541~546 (2010)
- Lisanby SH, "Sham TMS: intracerebral measurement of the induced electrical field and the induction of motor-evoked potentials", Biol Psychiatry, 49, pp.460~463 (2001)
- Loo CK, "Transcranial magnetic stimulation (TMS)in controlled treatment studies: are some "sham" forms active?", Biol Psychiatry, 47, pp.325~331 (2000)
- Friederici AD, "First-pass versus second-pass parsing processes in a Wernicke's and a Broca's aphasic: electrophysiological evidence for a double dissociation", Brain Lang, 62, pp.311~341 (1998)
- Hoffman RE, "Transcranial magnetic stimulation of left temporoparietal cortex and medication-resistant auditory hallucinations", Arch Gen Psychiatry, 60, pp.49~56 (2003)
- Kay SR, "The positive and negative syndrome scale (PANSS) for schizophrenia", Schizophr Bull, 13, pp.261~276 (1987)
- Addington D, "Assessing depression in schizophrenia: the Calgary Depression Scale", Br J Psychiatry Suppl, (22), pp.39~44 (1993)
- Sommer IE, "Left with the voices or hearing right? Lateralization of auditory verbal hallucinations in schizophrenia", J Psychiatry Neurosci, 28, pp.217~218 (2003)
- Mitchell RL, "Right hemisphere language functions and schizophrenia: the forgotten hemisphere?", Brain, 128, pp.963~978 (2005)
- Sommer IE, "Language lateralization in schizophrenia, an fMRI study", Schizophr Res, 52, pp.57~67 (2001)
- Vercammen A, "Effects of bilateral repetitive transcranial magnetic stimulation on treatment resistant auditory-verbal hallucinations in schizophrenia: a randomized controlled trial", Schizophr Res, 114, pp.172~179 (2009)
- Allen P, "Inner speech models of auditory verbal hallucinations: evidence from behavioural and neuroimaging studies", Int Rev Psychiatry, 19, pp.407~415 (2007)
- Lennox BR, "The functional anatomy of auditory hallucinations in schizophrenia", Psychiatry Res, 100, pp.13~20 (2000)
- Hoffman RE, "Probing the pathophysiology of auditory", verbal hallucinations by combining functional magnetic resonance imaging and transcranial magnetic stimulation, 2007, pp.17, 2733~2743
- Pascual-Leone A, "Study and modulation of human cortical excitability with transcranial magnetic stimulation", J Clin Neurophysiol, 15, pp.333~343 (1998)
- Paus T, "Dose-dependent reduction of cerebral blood flow during rapid-rate transcranial magnetic stimulation of the human sensorimotor cortex", J Neurophysiol, 79, pp.1102~1107 (1998)
- Hallett M., "Transcranial magnetic stimulation and the human brain", Nature, 406, pp.147~150 (2000)
- Devlin JT, "Stimulating language: insights from TMS", Brain, 130, pp.610~622 (2007)
- Ridding MC, "Is there a future for therapeutic use of transcranial magnetic stimulation?", Nat Rev Neurosci, 8, pp.559~567 (2007)
- Hoffman RE, "Temporoparietal transcranial magnetic stimulation for auditory hallucinations: safety, efficacy and moderators in a fifty patient sample", Biol Psychiatry, 58, pp.97~104 (2005)
- Chibbaro G, "Repetitive transcranial magnetic stimulation in schizophrenic patients reporting auditory hallucinations", Neurosci Lett, 383, pp.54~57 (2005)
- Loo C, "Double-blind controlled investigation of transcranial magnetic stimulation for the treatment of resistant major depression", Am J Psychiatry, 156, pp.946~948 (1999)