본문 바로가기
KERD
논문KCI 등재

Relationship between Loudness Dependence of Auditory-evoked Potentials and Suicidality

0

조회

0

다운로드

0

인용

0

참고문헌

키워드

초록

Objective: Serotonin concentration is associated with suicide in patients with major depressive disorder. Loudness dependence of auditory-evoked potentials (LDAEPs), a representative neurophysiological indicator, is related to serotonin activity. Therefore, this study aimed to investigate the relationship between LDAEPs and suicidal ideation, suicide attempts, and the severity of depression. Methods: We evaluated the scalp N1, P2, and N1/P2 LDAEPs along with standardized low-resolution brain electromagnetic tomography (sLORETA)-localized N1, P2, and N1/P2 LDAEPs of 221 patients with major depressive disorder. The demographic and clinical data of the patients, including data on suicidal ideation and previous suicide attempts, were obtained from clinical interviews and medical records. The severity of depression was assessed using the Beck Depression Inventory and Hamilton Depression Rating Scale, whereas suicidal ideation was evaluated using the Beck Scale for Suicidal Ideation (BSS). Results: The total BSS score was associated with low N1/P2 LDAEP (p = 0.045), whereas P2 sLORETA-LDAEP was associated with lower previous suicide attempts (p = 0.043). In addition, suicide attempt was correlated with an elevated P2 left sLORETA-LDAEP (coefficient = 4.638, p = 0.038). Conclusion: These findings suggest that suicidal ideation is associated with decreased LDAEP, whereas suicide attempt is associated with increased LDAEP.

Abstract

Objective: Serotonin concentration is associated with suicide in patients with major depressive disorder. Loudness dependence of auditory-evoked potentials (LDAEPs), a representative neurophysiological indicator, is related to serotonin activity. Therefore, this study aimed to investigate the relationship between LDAEPs and suicidal ideation, suicide attempts, and the severity of depression. Methods: We evaluated the scalp N1, P2, and N1/P2 LDAEPs along with standardized low-resolution brain electromagnetic tomography (sLORETA)-localized N1, P2, and N1/P2 LDAEPs of 221 patients with major depressive disorder. The demographic and clinical data of the patients, including data on suicidal ideation and previous suicide attempts, were obtained from clinical interviews and medical records. The severity of depression was assessed using the Beck Depression Inventory and Hamilton Depression Rating Scale, whereas suicidal ideation was evaluated using the Beck Scale for Suicidal Ideation (BSS). Results: The total BSS score was associated with low N1/P2 LDAEP (p = 0.045), whereas P2 sLORETA-LDAEP was associated with lower previous suicide attempts (p = 0.043). In addition, suicide attempt was correlated with an elevated P2 left sLORETA-LDAEP (coefficient = 4.638, p = 0.038). Conclusion: These findings suggest that suicidal ideation is associated with decreased LDAEP, whereas suicide attempt is associated with increased LDAEP.

참고문헌 (31)

  1. "Suicide worldwide in 2019. Global health estimates" (2021)[URL]
  2. Schildkraut JJ, "The catecholamine hypothesis of affective disorders : A review of supporting evidence. 1965", J Neuropsychiatry Clin Neurosci, 7, pp.524~533 (1995)
  3. Asberg M, "Cerebrospinal fluid studies in suicide. An overview", Ann N Y Acad Sci, 487, pp.243~255 (1986)
  4. O’Neill BV, "The loudness dependence of the auditory evoked potential(LDAEP)as an in vivo biomarker of central serotonergic function in humans : Rationale, evaluation and review of findings", Hum Psychopharmacol, 23, pp.355~370 (2008)
  5. Linka T, "The intensity dependence of auditory evoked ERP components predicts responsiveness to reboxetine treatment in major depression", Pharmacopsychiatry, 38, pp.139~143 (2005)
  6. Linka T, "The intensity dependence of the auditory evoked N1 component as a predictor of response to Citalopram treatment in patients with major depression", Neurosci Lett, 367, pp.375~378 (2004)
  7. Juckel G, "Differential prediction of first clinical response to serotonergic and noradrenergic antidepressants using the loudness dependence of auditory evoked potentials in patients with major depressive disorder", J Clin Psychiatry, 68, pp.1206~1212 (2007)
  8. Park YM, "The loudness dependence of the auditory evoked potential(LDAEP)as a predictor of the response to escitalopram in patients with generalized anxiety disorder", Psychopharmacology(Berl), 213, pp.625~632 (2011)
  9. Ernst C, "Suicide neurobiology", Prog Neurobiol, 89, pp.315~333 (2009)
  10. Beck AT, "An inventory for measuring depression", Arch Gen Psychiatry, 4, pp.561~571 (1961)
  11. Hamilton M, "A rating scale for depression", J Neurol Neurosurg Psychiatry, 23, pp.56~62 (1960)
  12. Patton JH, "Factor structure of the Barratt impulsiveness scale", J Clin Psychol, 51, pp.768~774 (1995)
  13. Maier W, "The Hamilton anxiety scale : reliability, validity and sensitivity to change in anxiety and depressive disorders", J Affect Disord, 14, pp.61~68 (1988)
  14. Beck AT, "Assessment of suicidal intention : The scale for suicide ideation", J Consult Clin Psychol, 47, pp.343~352 (1979)
  15. Pascual-Marqui RD, "Standardized low-resolution brain electromagnetic tomography(sLORETA) : Technical details", Methods Find Exp Clin Pharmacol, 24(Suppl D), pp.5~12 (2002)
  16. Lester D, "The concentration of neurotransmitter metabolites in the cerebrospinal fluid of suicidal individuals : A meta-analysis", Pharmacopsychiatry, 28, pp.45~50 (1995)
  17. Mann JJ, "Can biological tests assist prediction of suicide in mood disorders", Int J Neuropsychopharmacol, 9, pp.465~474 (2006)
  18. Kim DH, "The association between suicidality and serotonergic dysfunction in depressed patients", J Affect Disord, 148, pp.72~76 (2013)
  19. Chen TJ, "Serotonin dysfunction and suicide attempts in major depressives : An auditory event-related potential study", Neuropsychobiology, 52, pp.28~36 (2005)
  20. Park YM, "Serum BDNF levels in relation to illness severity, suicide attempts, and central serotonin activity in patients with major depressive disorder : a pilot study", PLoS One, 9, pp.e91061~ (2014)
  21. Park YM, "The association between serum lipid levels, suicide ideation, and central serotonergic activity in patients with major depressive disorder", J Affect Disord, 159, pp.62~65 (2014)
  22. Kim JS, "Auditory evoked potentials and suicidal behaviors in patients with major depressive disorders", Sci Rep, 11, pp.7255~ (2021)
  23. Min JA, "Clinical characteristics associated with different strengths of loudness dependence of auditory evoked potentials(LDAEP)in major depressive disorder", Psychiatry Res, 200, pp.374~381 (2012)
  24. Lee SH, "Clinical implications of loudness dependence of auditory evoked potentials in patients with atypical depression", Prog Neuropsychopharmacol Biol Psychiatry, 54, pp.7~12 (2014)
  25. Juckel G, "Evoked potentials, serotonin, and suicidality", Pharmacopsychiatry, 27(Suppl 1), pp.27~29 (1994)
  26. DeRubeis RJ, "Cognitive therapy vs medications in the treatment of moderate to severe depression", Arch Gen Psychiatry, 62, pp.409~416 (2005)
  27. Graßnickel V, "Loudness dependence of auditory evoked potentials(LDAEP)in clinical monitoring of suicidal patients with major depression in comparison with non-suicidal depressed patients and healthy volunteers : a follow-up-study", J Affect Disord, 184, pp.299~304 (2015)
  28. Mingyu Hwang, "Relationship Between the Loudness Dependence of the Auditory Evoked Potential and the Severity of Suicidal Ideation in Patients with Major Depressive Disorder", Clinical Psychopharmacology and Neuroscience, 19(2), pp.323~333 (2021), 대한정신약물학회[DOI]
  29. 박영민, "Relationship between Serotonergic Dysfunction Based on Loudness Dependence of Auditory-Evoked Potentials and Suicide in Patients with Major Depressive Disorder", PSYCHIATRY INVESTIGATION, 12(4), pp.421~424 (2015), 대한신경정신의학회[DOI]
  30. Uhl I, "Loudness dependence of auditory evoked potentials(LDAEP)in clinical monitoring of suicidal patients with major depression : A pilot study", Eur Arch Psychiatry Clin Neurosci, 262, pp.487~492 (2012)
  31. 박영민, "Can the Loudness Dependence of Auditory Evoked Potentials and Suicidality Be Used to Differentiate between Depressive Patients with and without Bipolarity", PSYCHIATRY INVESTIGATION, 10(2), pp.143~147 (2013), 대한신경정신의학회

관련 논문AI추천

Relationship Between the Loudness Dependence of the Auditory Evoked Potential and the Severity of Suicidal Ideation in Patients with Major Depressive Disorder우성일, 이민지, 한상우, Byungjoo Kang, Jaeuk Hwang, Mingyu Hwang, Yeon Jung Lee, Yun Sung Lee대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2021 · 제19권 제2호Can the Loudness Dependence of Auditory Evoked Potentials and Suicidality Be Used to Differentiate between Depressive Patients with and without Bipolarity박영민, 이승환대한신경정신의학회 · PSYCHIATRY INVESTIGATION2013 · 제10권 제2호Loudness dependence of auditory evoked potential의 임상적 활용박영민, 이승환, 정예원대한생물치료정신의학회 · 생물치료정신의학2012 · 제18권 제1호Does the Loudness Dependence of Auditory Evoked Potential Predict Response to Selective Serotonin Reuptake Inhibitors?: A Meta-analysis김유림, 이승환, Sunkyung Yoon대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2021 · 제19권 제2호주요 우울 장애, 정신분열병, 양극성 장애 및 정상 대조군에서의 N100 진폭 경사김상래, 양은경, 오성희, 이승환대한생물정신의학회 · 생물정신의학2009 · 제16권 제3호Impulsivity in Major Depressive Disorder Patients with Suicidal Ideation: Event-related Potentials in a GoNogo TaskJaeuk Hwang, Minjae Kim, Sang-Woo Hahn, Sung-il Woo, Yeon Jung Lee대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2023 · 제21권 제4호

이 간행물의 다른 논문 (18건)