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Impulsivity in Major Depressive Disorder Patients with Suicidal Ideation: Event-related Potentials in a GoNogo Task

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Objective: Suicidal ideation is one of the strongest predictors of suicide, and its relevance to impulsivity in depressed patients has been accumulated. Furthermore, high impulsivity patients show the attenuation of the Nogo amplitude in the GoNogo event-related potential (ERP). The purpose of the current study is to determine the correlation of Nogo ERP to the suicidal ideation depending on the condition of its presence or absence in major depressive disorder (MDD) patients. Methods: A total 162 participants (104 patients with suicidal ideation, 31 patients without suicidal ideation, and 27 healthy controls) were recruited, and performed GoNogo tasks during the electroencephalogram measurement. Depression, anxiety, suicidal ideation and impulsivity were assessed by self-rating scales. The clinical measures, behavioral data and Nogo ERP were compared among groups. Results: The MDD with suicidal ideation (SI) group showed significantly decreased Nogo P3 amplitudes compared to MDD without SI (Fz and Cz electrodes) and control group (all electrodes). The MDD with SI group also had significantly low accuracy of both Go and Nogo trails, compared to the MDD without group. The Nogo P3 amplitudes showed the negative relation to the scores of impulsivity, depression, anxiety and SI. Conclusion: Our results concluded that the Nogo P3 ERP amplitude was decreased in MDD patients with SI compared to MDD patients without SI and controls. These findings suggest that the decreased Nogo P3 amplitude is the one of the candidate biomarker for impulsivity in MDD patients to evaluating SI.

Abstract

Objective: Suicidal ideation is one of the strongest predictors of suicide, and its relevance to impulsivity in depressed patients has been accumulated. Furthermore, high impulsivity patients show the attenuation of the Nogo amplitude in the GoNogo event-related potential (ERP). The purpose of the current study is to determine the correlation of Nogo ERP to the suicidal ideation depending on the condition of its presence or absence in major depressive disorder (MDD) patients. Methods: A total 162 participants (104 patients with suicidal ideation, 31 patients without suicidal ideation, and 27 healthy controls) were recruited, and performed GoNogo tasks during the electroencephalogram measurement. Depression, anxiety, suicidal ideation and impulsivity were assessed by self-rating scales. The clinical measures, behavioral data and Nogo ERP were compared among groups. Results: The MDD with suicidal ideation (SI) group showed significantly decreased Nogo P3 amplitudes compared to MDD without SI (Fz and Cz electrodes) and control group (all electrodes). The MDD with SI group also had significantly low accuracy of both Go and Nogo trails, compared to the MDD without group. The Nogo P3 amplitudes showed the negative relation to the scores of impulsivity, depression, anxiety and SI. Conclusion: Our results concluded that the Nogo P3 ERP amplitude was decreased in MDD patients with SI compared to MDD patients without SI and controls. These findings suggest that the decreased Nogo P3 amplitude is the one of the candidate biomarker for impulsivity in MDD patients to evaluating SI.

참고문헌 (63)

  1. Ballesteros MF, "A review of CDC’s Web-based Injury Statistics Query and Reporting System(WISQARSTM) : Planning for the future of injury surveillance", J Safety Res, 61, pp.211~215 (2017)
  2. OECD, "Health at a glance 2019: OECD indicators" (2019), OECD Publishing
  3. Statistics Korea, "The suicide rate in Kroea", Statistics Korea, ~ (2021)
  4. Hyun KR, "Socio-economic cost analysis of the top five causes of death in Korea", Health Insur Policy, 13, pp.91~107 (2014)
  5. 2020 Psychological autopsy report, "Korea Foundation for Suicide Prevention", Ministry of Health and Welfare, ~ (2020)
  6. Brunoni AR, "Acute suicidal ideation in middle-aged adults from Brazil. Results from the baseline data of the Brazilian Longitudinal Study of Adult Health(ELSA-Brasil)", Psychiatry Res, 225, pp.556~562 (2015)
  7. Farmer A, "The Cardiff sib-pair study : Suicidal ideation in depressed and healthy subjects and their siblings", Crisis, 22, pp.71~73 (2001)
  8. Gao K, "Disagreement between self-reported and clinician-ascertained suicidal ideation and its correlation with depression and anxiety severity in patients with major depressive disorder or bipolar disorder", J Psychiatr Res, 60, pp.117~124 (2015)
  9. Sokero TP, "Suicidal ideation and attempts among psychiatric patients with major depressive disorder", J Clin Psychiatry, 64, pp.1094~1100 (2003)
  10. Chan LF, "Are predictors of future suicide attempts and the transition from suicidal ideation to suicide attempts shared or distinct : A 12-month prospective study among patients with depressive disorders", Psychiatry Res, 220, pp.867~873 (2014)
  11. May AM, "Predicting future suicide attempts among depressed suicide ideators : A 10-year longitudinal study", J Psychiatr Res, 46, pp.946~952 (2012)
  12. Maguire A, "RF12 Suicide ideation and mortality risk : Population wide data linkage study", J Epidemiol Community Health, 73(Suppl 1), pp.A60~ (2019)
  13. Chamberlain P, "Suicidal ideation. The clinical utility of the K10", Crisis, 30, pp.39~42 (2009)
  14. Vuorilehto M, "Method of assessment determines prevalence of suicidal ideation among patients with depression", Eur Psychiatry, 29, pp.338~344 (2014)
  15. Anestis MD, "Reconsidering the link between impulsivity and suicidal behavior", Pers Soc Psychol Rev, 18, pp.366~386 (2014)
  16. Anestis MD, "Examining the role of emotion in suicidality : Negative urgency as an amplifier of the relationship between components of the interpersonal-psychological theory of suicidal behavior and lifetime number of suicide attempts", J Affect Disord, 129, pp.261~269 (2011)
  17. Dvorak RD, "Alcohol use, depressive symptoms, and impulsivity as risk factors for suicide proneness among college students", J Affect Disord, 149, pp.326~334 (2013)
  18. Franklin JC, "Risk factors for suicidal thoughts and behaviors : A meta-analysis of 50 years of research", Psychol Bull, 143, pp.187~232 (2017)
  19. Chang BP, "Biological risk factors for suicidal behaviors : A meta-analysis", Transl Psychiatry, 6, pp.e887~ (2016)
  20. Corrigan MH, "Panic, suicide, and agitation : Independent correlates of the TSH response to TRH in depression", Biol Psychiatry, 31, pp.984~992 (1992)
  21. Sudol K, "Biomarkers of suicide attempt behavior : Towards a biological model of risk", Curr Psychiatry Rep, 19, pp.31~ (2017)
  22. Wei S, "Amygdala functional connectivity in female patients with major depressive disorder with and without suicidal ideation", Ann Gen Psychiatry, 17, pp.37~ (2018)
  23. Oquendo MA, "Positron emission tomography of regional brain metabolic responses to a serotonergic challenge and lethality of suicide attempts in major depression", Arch Gen Psychiatry, 60, pp.14~22 (2003)
  24. Sur S, "Event-related potential : An overview", Ind Psychiatry J, 18, pp.70~73 (2009)
  25. Luck SJ, "An introduction to the event-related potential technique" (2014), The MIT press
  26. Hajcak G, "The utility of event-related potentials in clinical psychology", Annu Rev Clin Psychol, 15, pp.71~95 (2019)
  27. Smith JL, "Motor and nonmotor inhibition in the Go", NoGo task : An ERP and fMRI study, 2013, pp.87, 244~253
  28. Wang Y, "The impact of emotion valence on brain processing of behavioral inhibitory control : Spatiotemporal dynamics", Neurosci Lett, 502, pp.112~116 (2011)
  29. Yeung N, "The neural basis of error detection : Conflict monitoring and the error-related negativity", Psychol Rev, 111, pp.931~959 (2004)
  30. Albert J, "Emotional context modulates response inhibition : Neural and behavioral data", Neuroimage, 49, pp.914~921 (2010)
  31. Kamp SM, "ERP and pupil responses to deviance in an oddball paradigm", Psychophysiology, 52, pp.460~471 (2015)
  32. Ruchsow M, "Response inhibition in borderline personality disorder:Event-related potentials in a Go", Nogo task, 2008, pp.115, 127~133
  33. Buchmann J, "Intelligence moderates impulsivity and attention in ADHD children : An ERP study using a go", nogo paradigm, 2011, pp.12(Suppl 1), 35~39
  34. Guan M, "Impaired response inhibition in juvenile delinquents with antisocial personality characteristics : A preliminary ERP study in a Go", Nogo task, 2015, pp.603, 1~5
  35. Albanese BJ, "Impaired conflict detection differentiates suicide attempters from ideating nonattempters : Evidence from eventrelated potentials", Biol Psychiatry Cogn Neurosci Neuroimaging, 4, pp.902~912 (2019)
  36. American Psychiatric Association, "Diagnostic and statistical manual of mental disorders, 5th Edition (DSM-5)", pp.947~ (2013), American Psychiatric Association
  37. Murphy K, "Preliminary normative data on DSM-IV criteria for adults", ADHD Report, 3, pp.6~7 (1995)
  38. 김은정, "한국형 성인 ADHD 척도의 타당화 연구: 대학생 표본을 중심으로", Korean Journal of Clinical Psychology, 22(4), pp.897~911 (2003), 한국임상심리학회
  39. Beck AT, "Scale for Suicide Ideation : Psychometric properties of a self-report version", J Clin Psychol, 44, pp.499~505 (1988)
  40. Shin MS, "A study of suicidal ideation among high school students : The structural relation among depression, hopelessness, and suicidal ideation", Korean J Clin Psychol, 9, pp.1~19 (1990)
  41. 성형모, "한국어판 백 우울 설문지 2판의 신뢰도 및 타당도 연구", 생물치료정신의학, 14(2), pp.201~212 (2008), 대한생물치료정신의학회
  42. Kwon SM, "Differential causal roles of dysfunctional attitudes and automatic thoughts in depression", Cognit Ther Res, 16, pp.309~328 (1992)
  43. Yook SP, "A clinical study on the Korean version of Beck Anxiety Inventory : Comparative study of patient and non-patient", Korean J Clin Psychol, 16, pp.185~197 (1997)
  44. Hartmann L, "Enhancing frontal top-down inhibitory control with Go", NoGo training, 2016, pp.221, 3835~3842
  45. Liu Q, "Effects of 72 hours total sleep deprivation on male astronauts’ executive functions and emotion", Compr Psychiatry, 61, pp.28~35 (2015)
  46. Brodeur DA, "The development of selective attention in children with attention deficit hyperactivity disorder", J Abnorm Child Psychol, 29, pp.229~239 (2001)
  47. Rubia K, "Performance of children with attention deficit hyperactivity disorder(ADHD)on a test battery of impulsiveness", Child Neuropsychol, 13, pp.276~304 (2007)
  48. Bohne A, "Motor inhibition in trichotillomania and obsessive-compulsive disorder", J Psychiatr Res, 42, pp.141~150 (2008)
  49. Nguyen AT, "N2 and P3 modulation during partial inhibition in a modified go", nogo task, 2016, pp.107, 63~71
  50. Smith JL, "Movement-related potentials in the Go", NoGo task : The P3 reflects both cognitive and motor inhibition, 2008, pp.119, 704~714
  51. Hong X, "Segregating Top-Down selective attention from response inhibition in a spatial cueing Go", NoGo Task : An ERP and source localization study, 2017, pp.7, 9662~
  52. Murni NI, "Moderation effect of impulsivity in the relationship between depression and suicide ideation among late adolescent in Malaysia", Sciences, 10, pp.110~119 (2020)
  53. Wang YY, "Role of depression severity and impulsivity in the relationship between hopelessness and suicidal ideation in patients with major depressive disorder", J Affect Disord, 183, pp.83~89 (2015)
  54. Zhang J, "Impulsiveness indirectly affects suicidal ideation through depression and simultaneously moderates the indirect effect : A moderated mediation path model", Front Psychiatry, 13, pp.913680~ (2022)
  55. Zhang R, "Dorsolateral and ventrolateral prefrontal cortex structural changes relative to suicidal ideation in patients with depression", Acta Neuropsychiatr, 32, pp.84~91 (2020)
  56. Aron AR, "Inhibition and the right inferior frontal cortex : One decade on", Trends Cogn Sci, 18, pp.177~185 (2014)
  57. Yoon SH, "Electrophysiological changes between patients with suicidal ideation and suicide attempts : An event-related potential study", Front Psychiatry, 13, pp.900724~ (2022)
  58. Ruchsow M, "Impulsiveness and ERP components in a Go", Nogo task, 2008, pp.115, 909~915
  59. Bartholow BD, "Strategic control and medial frontal negativity : Beyond errors and response conflict", Psychophysiology, 42, pp.33~42 (2005)
  60. Ruchsow M, "Executive control in obsessive-compulsive disorder: Eventrelated potentials in a Go", Nogo task, 2007, pp.114, 1595~1601
  61. Cáceda R, "Modes of resting functional brain organization differentiate suicidal thoughts and actions : A preliminary study", J Clin Psychiatry, 79, pp.17~ (2018)
  62. Dai Z, "Disrupted fronto-parietal network and default-mode network gamma interactions distinguishing suicidal ideation and suicide attempt in depression", Prog Neuropsychopharmacol Biol Psychiatry, 113, pp.110475~ (2022)
  63. Minzenberg MJ, "Conflict-related anterior cingulate functional connectivity is associated with past suicidal ideation and behavior in recent-onset schizophrenia", J Psychiatr Res, 65, pp.95~101 (2015)

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