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Loudness dependence of auditory evoked potential의 임상적 활용

Practical use of loudness dependence of auditory evoked potential

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주제분류정신과학

초록

The loudness dependence of auditory evoked potentials (LDAEP) showed a valid indicator of central serotonergic activity in humans. The LDAEP has been identified as being inversely associated with central serotonergic activity, with a high LDAEP reflecting low serotonergic neurotransmission. It was also found that blood serotonin concentration was negatively correlated with corresponding changes of the LDAEP. Serotonergic neurotransmission modulates sensory processing in the primary auditory cortex. Thus, the serotonergic system is well suited for a tonic modulation of auditory cortical processing. The reactivity of the auditory cortex can be assessed using LDAEP. Based on these findings, there is a significant correlation between a strong LDAEP indicating low serotonergic function and a favorable response to SSRIs in depressed patients with major depressive disorder, bipolar disorder, and generalized anxiety disorder. In addition, the findings of the recent researches reveal that patients with major psychiatric disorders exhibit different strengths of LDAEP according to their serotonin-related pathology. Measurement of the LDAEP appears to be a clinically useful tool, providing information regarding the pathophysiology underlying major psychiatric disorders and treatment response. Future studies should employ larger samples with controlling the interference variables.

Abstract

The loudness dependence of auditory evoked potentials (LDAEP) showed a valid indicator of central serotonergic activity in humans. The LDAEP has been identified as being inversely associated with central serotonergic activity, with a high LDAEP reflecting low serotonergic neurotransmission. It was also found that blood serotonin concentration was negatively correlated with corresponding changes of the LDAEP. Serotonergic neurotransmission modulates sensory processing in the primary auditory cortex. Thus, the serotonergic system is well suited for a tonic modulation of auditory cortical processing. The reactivity of the auditory cortex can be assessed using LDAEP. Based on these findings, there is a significant correlation between a strong LDAEP indicating low serotonergic function and a favorable response to SSRIs in depressed patients with major depressive disorder, bipolar disorder, and generalized anxiety disorder. In addition, the findings of the recent researches reveal that patients with major psychiatric disorders exhibit different strengths of LDAEP according to their serotonin-related pathology. Measurement of the LDAEP appears to be a clinically useful tool, providing information regarding the pathophysiology underlying major psychiatric disorders and treatment response. Future studies should employ larger samples with controlling the interference variables.

참고문헌 (32)

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관련 논문AI추천

정신질환에서 Loudness Dependence of Auditory Evoked Potential (LDAEP)의 임상적 의미이승환대한생물정신의학회 · 생물정신의학2012 · 제19권 제1호Does the Loudness Dependence of Auditory Evoked Potential Predict Response to Selective Serotonin Reuptake Inhibitors?: A Meta-analysis김유림, 이승환, Sunkyung Yoon대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2021 · 제19권 제2호Relationship between Loudness Dependence of Auditory-evoked Potentials and SuicidalityMiseon Shim, Seung-Hwan Lee, Youngjun Cho, Young-Min Park대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2023 · 제21권 제4호주요 우울 장애, 정신분열병, 양극성 장애 및 정상 대조군에서의 N100 진폭 경사김상래, 양은경, 오성희, 이승환대한생물정신의학회 · 생물정신의학2009 · 제16권 제3호Relationship Between the Loudness Dependence of the Auditory Evoked Potential and the Severity of Suicidal Ideation in Patients with Major Depressive Disorder우성일, 이민지, 한상우, Byungjoo Kang, Jaeuk Hwang, Mingyu Hwang, Yeon Jung Lee, Yun Sung Lee대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2021 · 제19권 제2호The Hypothesis on the Prediction of Treatment Response with Buspirone Augmentation along with Serotonergic Antidepressant in Patients with Major Depressive Disorder Using Loudness Dependence of Auditory Evoked Potentials: Two Cases and Review of the Literature for EvidenceYoung-Min Park대한신경정신의학회 · PSYCHIATRY INVESTIGATION2020 · 제17권 제3호

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