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주요 우울 장애, 정신분열병, 양극성 장애 및 정상 대조군에서의 N100 진폭 경사

N100 Amplitude Slopes in major depressive disorder, bipolar disorder, schizophrenia and normal controls

이승환|김상래|오성희|양은경
대한생물정신의학회 (The Korean Society Of Biological Psychiatry)|2009.08|생물정신의학 (Journal of Korean Society of Biological Psychiatry)|제16권 제3호|pp. 181-189

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참고문헌

키워드

SchizophreniaBipolar disorderMajor depressive disorderN100 amplitude slopeCentral serotonergic neurotransmission
주제분류정신과학

초록

Objectives: N100 amplitude slope(the intensity dependence of the cortical auditory evoked potentials) is widely considered as an indirect indicator of central serotonergic neurotransmission. However, there are only a few studies about N100 amplitude slopes of major psychiatric disorders. In this study, we examined N100 amplitude slope differences among major depressive disorder(MDD), bipolar disorder(BD), schizophrenia(SCZ) and normal controls(NC). Methods: We measured the N100 amplitude slopes of 35 patients with MDD, 33 patients with BD, 27 patients with SCZ and 35 NC subjects. Amplitude differences from N1 to P2 at the five different sound intensities (55, 65, 75, 85 and 95 dB) were examined at Cz electrode. The N100 amplitude slope was calculated as the linear regression of five N1/P2 peak-to-peak amplitudes across stimulus intensities. Results: BD patients showed significantly reduced N100 amplitude slope compared with NC(0.54±0.70 vs 0.96±0.72, p=0.035). N100 amplitude slope of SCZ patients was significantly reduced compared with NC(0.50±0.47 vs 0.96±0.72, p=0.027). N100 amplitude slope of BD patients was significantly lower than that of MDD patients(0.54±0.70 vs 0.94±0.60, p=0.046). SCZ patients also showed significant reduction of N100 amplitude slope compared with MDD patients(0.50±0.47 vs 0.94±0.60, p=0.036). There was no significant difference of N100 amplitude slope between MDD patients and NC(0.94±0.60 vs 0.96±0.72, p=1.000). Conclusion: Interestingly, the N100 amplitude slopes of BD and SCZ were reduced compared to NC and MDD patients. Our results suggest the predictive use of N100 amplitude slope in making differential diagnoses of major psychiatric disorders. Clinical implications of N100 amplitude slope in major psychiatric disorders were discussed.

Abstract

Objectives: N100 amplitude slope(the intensity dependence of the cortical auditory evoked potentials) is widely considered as an indirect indicator of central serotonergic neurotransmission. However, there are only a few studies about N100 amplitude slopes of major psychiatric disorders. In this study, we examined N100 amplitude slope differences among major depressive disorder(MDD), bipolar disorder(BD), schizophrenia(SCZ) and normal controls(NC). Methods: We measured the N100 amplitude slopes of 35 patients with MDD, 33 patients with BD, 27 patients with SCZ and 35 NC subjects. Amplitude differences from N1 to P2 at the five different sound intensities (55, 65, 75, 85 and 95 dB) were examined at Cz electrode. The N100 amplitude slope was calculated as the linear regression of five N1/P2 peak-to-peak amplitudes across stimulus intensities. Results: BD patients showed significantly reduced N100 amplitude slope compared with NC(0.54±0.70 vs 0.96±0.72, p=0.035). N100 amplitude slope of SCZ patients was significantly reduced compared with NC(0.50±0.47 vs 0.96±0.72, p=0.027). N100 amplitude slope of BD patients was significantly lower than that of MDD patients(0.54±0.70 vs 0.94±0.60, p=0.046). SCZ patients also showed significant reduction of N100 amplitude slope compared with MDD patients(0.50±0.47 vs 0.94±0.60, p=0.036). There was no significant difference of N100 amplitude slope between MDD patients and NC(0.94±0.60 vs 0.96±0.72, p=1.000). Conclusion: Interestingly, the N100 amplitude slopes of BD and SCZ were reduced compared to NC and MDD patients. Our results suggest the predictive use of N100 amplitude slope in making differential diagnoses of major psychiatric disorders. Clinical implications of N100 amplitude slope in major psychiatric disorders were discussed.

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