A Case of Acute Myeloid Leukemia Concurrent With Untreated Chronic Lymphocytic Leukemia
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Dear Editor, The association of CLL with hematologic malignancies such as AML is relatively rare [1, 2], with mostly associated with prior cytotoxic chemotherapy [3]. Few reports of untreated CLL manifesting with or followed by AML suggested that each tumor probably evolved from simultaneous expansion of two independent clones, not a common clone [1]. Concomitant AML and CLL having a common clonal origin is exceptional, and to our knowledge, only two cases were reported previously [4, 5]. We present a case of de novo AML concurrent with untreated CLL, with two karyotypic abnormalities in the same clone.
Abstract
Dear Editor, The association of CLL with hematologic malignancies such as AML is relatively rare [1, 2], with mostly associated with prior cytotoxic chemotherapy [3]. Few reports of untreated CLL manifesting with or followed by AML suggested that each tumor probably evolved from simultaneous expansion of two independent clones, not a common clone [1]. Concomitant AML and CLL having a common clonal origin is exceptional, and to our knowledge, only two cases were reported previously [4, 5]. We present a case of de novo AML concurrent with untreated CLL, with two karyotypic abnormalities in the same clone.
참고문헌 (8)
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