Drug Resistance Patterns of Multidrug- and Extensively Drug-Resistant Tuberculosis in Korea: Amplification of Resistance to Oral Second-line Drugs
1
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
We aimed to analyze the drug resistance patterns of multidrug-resistant and extensively drug-resistant tuberculosis (TB) and the difference of drug resistance among various settings for health care in Korea. The data of drug susceptibility testing in 2009 was analyzed in order to secure sufficient number of patients from various settings in Korea. Patients were categorized by types of institutions into four groups, which comprised new and previously treated patients from public health care centers (PHC), the private sector, and Double-barred Cross clinics (DBC). The resistance rates to first-line drugs were uniformly high in every group. While the resistance rates to second-line drugs were not as high as first-line drugs, there was a pattern that drug resistance rates were lowest for PHC and highest for DBC. The differences of the resistance rates were more prominent for oral second-line drugs. Our findings implied that drug resistance to oral second-line drugs was significantly amplified during multidrug-resistant-TB treatment in Korea. Therefore, an individualized approach is recommended for treating drug-resistant-TB based on susceptibility testing results to prevent acquisition or amplification of drug resistance.
Abstract
We aimed to analyze the drug resistance patterns of multidrug-resistant and extensively drug-resistant tuberculosis (TB) and the difference of drug resistance among various settings for health care in Korea. The data of drug susceptibility testing in 2009 was analyzed in order to secure sufficient number of patients from various settings in Korea. Patients were categorized by types of institutions into four groups, which comprised new and previously treated patients from public health care centers (PHC), the private sector, and Double-barred Cross clinics (DBC). The resistance rates to first-line drugs were uniformly high in every group. While the resistance rates to second-line drugs were not as high as first-line drugs, there was a pattern that drug resistance rates were lowest for PHC and highest for DBC. The differences of the resistance rates were more prominent for oral second-line drugs. Our findings implied that drug resistance to oral second-line drugs was significantly amplified during multidrug-resistant-TB treatment in Korea. Therefore, an individualized approach is recommended for treating drug-resistant-TB based on susceptibility testing results to prevent acquisition or amplification of drug resistance.
참고문헌 (13)
- "Multidrug and extensively drug-resistant TB (M/XDR-TB): 2010 global report on surveillance and response"[URL]
- Kim DH, "Treatment outcomes and long-term survival in patients with extensively drug-resistant tuberculosis", Am J Respir Crit Care Med, 178, pp.1075~1082 (2008)
- Bai GH, "Trend of anti-tuberculosis drug resistance in Korea, 1994-2004", Int J Tuberc Lung Dis, 11, pp.571~576 (2007)
- Yoon-Sung Park, "The National Status of Tuberculosis Using Nationwide Medical Records Survey of Patients with Tuberculosis in Korea", Tuberculosis and Respiratory Diseases, 73(1), pp.48~55 (2012), 대한결핵및호흡기학회[DOI]
- Shah NS, "Worldwide emergence of extensively drug-resistant tuberculosis", Emerg Infect Dis, 13, pp.380~387 (2007)
- Kim CK, "Simple, direct drug susceptibility testing technique for diagnosis of drug-resistant tuberculosis in resource-poor settings", Int J Tuberc Lung Dis, 17, pp.1212~1216 (2013)
- Wayne LG, "Simple pyrazinamidase and urease tests for routine identification of mycobacteria", Am Rev Respir Dis, 109, pp.147~151 (1974)
- Kim JH, "Achievements in and challenges of tuberculosis control in South Korea", Emerg Infect Dis, 21, pp.1913~1920 (2015)
- Annual report on the notified tuberculosis in Korea, 2015, "Korea Centers for Disease Control and Prevention", Korea Centers for Disease Control and Prevention, ~ (2016)
- Zafar Ullah AN, "Effectiveness of involving the private medical sector in the National TB Control Programme in Bangladesh: evidence from mixed methods", BMJ Open, 2(6), pp.3001534~ (2012)
- WHO, "Companion handbook to the WHO guidelines for the programmatic management of drug-resistant tuberculosis", WHO, ~ (2014)
- Yew WW, "Fluoroquinolone resistance in Mycobacterium tuberculosis. What have we learnt?", Int J Tuberc Lung Dis, 18, pp.1~2 (2014)
- Yuen CM, "Association between regimen composition and treatment response in patients with multidrug-resistant tuberculosis: A prospective cohort study", PLoS Med, 12, pp.e1001932~ (2015)