A Case of Therapy-Related Acute Myeloid Leukemia With a Normal Karyotype After Sustained Molecular Complete Remission of Acute Promyelocytic Leukemia
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Dear editor, Given that the current therapeutic regimen for acute promyelo- cytic leukemia (APL) includes idarubicin (a topoisomerase II in- hibitor) and methotrexate (an alkylating agent), therapy-related acute myeloid leukemia (t-AML) can develop after APL treat- ment, and several cases have been reported to date [1-13]. Most of these cases involved the development of secondary clonal cy- togenetic abnormalities following successful treatment of APL, and, to our knowledge, only 2 cases involving a normal karyotype at t-AML diagnosis have been reported [5, 12]. We report a rare case of t-AML with a normal karyotype after sustained molecular complete remission of APL.
Abstract
Dear editor, Given that the current therapeutic regimen for acute promyelo- cytic leukemia (APL) includes idarubicin (a topoisomerase II in- hibitor) and methotrexate (an alkylating agent), therapy-related acute myeloid leukemia (t-AML) can develop after APL treat- ment, and several cases have been reported to date [1-13]. Most of these cases involved the development of secondary clonal cy- togenetic abnormalities following successful treatment of APL, and, to our knowledge, only 2 cases involving a normal karyotype at t-AML diagnosis have been reported [5, 12]. We report a rare case of t-AML with a normal karyotype after sustained molecular complete remission of APL.
참고문헌 (14)
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