Diffusion Tensor Tractography Analysis of the Corpus Callosum Fibers in Amyotrophic Lateral Sclerosis
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Background and Purpose Involvement of the corpus callosum (CC) is reported to be aconsistent feature of amyotrophic lateral sclerosis (ALS). We examined the CC pathology using diffusion tensor tractography analysis to identify precisely which fiber bundles are involvedin ALS. Methods Diffusion tensor imaging was performed in 14 sporadic ALS patients and 16 agematched healthy controls. Whole brain tractography was performed using the multiple-regionof interest (ROI) approach, and CC fiber bundles were extracted in two ways based on functional and structural relevance: (i) cortical ROI selection based on Brodmann areas (BAs), and(ii) the sulcal-gyral pattern of cortical gray matter using FreeSurfer software, respectively. Results The mean fractional anisotropy (FA) values of the CC fibers interconnecting the primary motor (BA4), supplementary motor (BA6), and dorsolateral prefrontal cortex (BA9/46)were significantly lower in ALS patients than in controls, whereas those of the primary sensorycortex (BA1, BA2, BA3), Broca’s area (BA44/45), and the orbitofrontal cortex (BA11/47) didnot differ significantly between the two groups. The FreeSurfer ROI approach revealed a verysimilar pattern of abnormalities. In addition, a significant correlation was found between themean FA value of the CC fibers interconnecting the primary motor area and disease severity, asassessed using the revised Amyotrophic Lateral Sclerosis Functional Rating Scale, and theclinical extent of upper motor neuron signs. Conclusions Our findings suggest that there is some degree of selectivity or a gradient in theCC pathology in ALS. The CC fibers interconnecting the primary motor and dorsolateral prefrontal cortices may be preferentially involved in ALS.
Abstract
Background and Purpose Involvement of the corpus callosum (CC) is reported to be aconsistent feature of amyotrophic lateral sclerosis (ALS). We examined the CC pathology using diffusion tensor tractography analysis to identify precisely which fiber bundles are involvedin ALS. Methods Diffusion tensor imaging was performed in 14 sporadic ALS patients and 16 agematched healthy controls. Whole brain tractography was performed using the multiple-regionof interest (ROI) approach, and CC fiber bundles were extracted in two ways based on functional and structural relevance: (i) cortical ROI selection based on Brodmann areas (BAs), and(ii) the sulcal-gyral pattern of cortical gray matter using FreeSurfer software, respectively. Results The mean fractional anisotropy (FA) values of the CC fibers interconnecting the primary motor (BA4), supplementary motor (BA6), and dorsolateral prefrontal cortex (BA9/46)were significantly lower in ALS patients than in controls, whereas those of the primary sensorycortex (BA1, BA2, BA3), Broca’s area (BA44/45), and the orbitofrontal cortex (BA11/47) didnot differ significantly between the two groups. The FreeSurfer ROI approach revealed a verysimilar pattern of abnormalities. In addition, a significant correlation was found between themean FA value of the CC fibers interconnecting the primary motor area and disease severity, asassessed using the revised Amyotrophic Lateral Sclerosis Functional Rating Scale, and theclinical extent of upper motor neuron signs. Conclusions Our findings suggest that there is some degree of selectivity or a gradient in theCC pathology in ALS. The CC fibers interconnecting the primary motor and dorsolateral prefrontal cortices may be preferentially involved in ALS.
참고문헌 (46)
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