Current Clinical Applications of Diffusion-Tensor Imaging in Neurological Disorders
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초록
Diffusion-tensor imaging (DTI) is a noninvasive medical imaging tool used to investigate thestructure of white matter. The signal contrast in DTI is generated by differences in the Brownianmotion of the water molecules in brain tissue. Postprocessed DTI scalars can be used toevaluate changes in the brain tissue caused by disease, disease progression, and treatment responses,which has led to an enormous amount of interest in DTI in clinical research. This reviewarticle provides insights into DTI scalars and the biological background of DTI as a relativelynew neuroimaging modality. Further, it summarizes the clinical role of DTI in variousdisease processes such as amyotrophic lateral sclerosis, multiple sclerosis, Parkinson’s disease,Alzheimer’s dementia, epilepsy, ischemic stroke, stroke with motor or language impairment,traumatic brain injury, spinal cord injury, and depression. Valuable DTI postprocessing toolsfor clinical research are also introduced.
Abstract
Diffusion-tensor imaging (DTI) is a noninvasive medical imaging tool used to investigate thestructure of white matter. The signal contrast in DTI is generated by differences in the Brownianmotion of the water molecules in brain tissue. Postprocessed DTI scalars can be used toevaluate changes in the brain tissue caused by disease, disease progression, and treatment responses,which has led to an enormous amount of interest in DTI in clinical research. This reviewarticle provides insights into DTI scalars and the biological background of DTI as a relativelynew neuroimaging modality. Further, it summarizes the clinical role of DTI in variousdisease processes such as amyotrophic lateral sclerosis, multiple sclerosis, Parkinson’s disease,Alzheimer’s dementia, epilepsy, ischemic stroke, stroke with motor or language impairment,traumatic brain injury, spinal cord injury, and depression. Valuable DTI postprocessing toolsfor clinical research are also introduced.
참고문헌 (107)
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