Wallerian Degeneration of Insufficiently Affected White Matters in Old Infarction: Tract of Interest Analysis of Diffusion Tensor Imaging
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The application of diffusion tensor imaging (DTI) and fiber tractography to Wallerian degeneration (WD) is important because this technique is a very potent tools for quantitatively evaluating fiber tracts in vivo brain. We analyzed a case and control using tracts of interest (TOI) analysis to quantify WD. We scanned a case of old infarction and an age-matched healthy volunteer. T1 magnetization prepared rapid acquisition gradient echo (MPRAGE), fluid attenuated inversion recovery (FLAIR) and 12-direction diffusion tensor imaging (DTI) were obtained and analyzed using TOI analysis. The value of mean diffusity (Dav) and fracional anisotrophy (FA) were analyzed statistically by MWU test. A p-value of less than 0.05 was considered to indicate statistical significance. A comparison of the global fiber diffusion characteristics shows WD of both the corpus callosum and the ipsilateral superior longitudinal fasciculus. The corpus callosum in particular showed trans-hemispherical degeneration. Local fiber characteristics along the geodesic paths show WD in the corpus callosum, ipsilateral superior longitudinal fasciculus, ipsilateral corticospinal tract, and ipsilateral corticothalamic tract. We have demonstrated changes in Dav and FA values and a clear correspondence with the WD in various tracts. TOI analysis successfully revealed radial WD in white matter tracts from a region of encephalomalacia and primary gliosis, although they were only slightly affected.
Abstract
The application of diffusion tensor imaging (DTI) and fiber tractography to Wallerian degeneration (WD) is important because this technique is a very potent tools for quantitatively evaluating fiber tracts in vivo brain. We analyzed a case and control using tracts of interest (TOI) analysis to quantify WD. We scanned a case of old infarction and an age-matched healthy volunteer. T1 magnetization prepared rapid acquisition gradient echo (MPRAGE), fluid attenuated inversion recovery (FLAIR) and 12-direction diffusion tensor imaging (DTI) were obtained and analyzed using TOI analysis. The value of mean diffusity ( D av ) and fracional anisotrophy (FA) were analyzed statistically by MWU test. A p-value of less than 0.05 was considered to indicate statistical significance. A comparison of the global fiber diffusion characteristics shows WD of both the corpus callosum and the ipsilateral superior longitudinal fasciculus. The corpus callosum in particular showed trans-hemispherical degeneration. Local fiber characteristics along the geodesic paths show WD in the corpus callosum, ipsilateral superior longitudinal fasciculus, ipsilateral corticospinal tract, and ipsilateral corticothalamic tract. We have demonstrated changes in D av and FA values and a clear correspondence with the WD in various tracts. TOI analysis successfully revealed radial WD in white matter tracts from a region of encephalomalacia and primary gliosis, although they were only slightly affected.
참고문헌 (26)
- Waller A, "Experiments on the section of the glossopharyngeal and hypoglossal nerves of the frog and observation of the alteration produced thereby in the structure of primitive fibres", 140, pp.42329~ (1850)
- Graham DI, "Greenfield's neuropathology", pp.104~107 (1997)
- Kuhn MJ, "Wallerian degeneration after cerebral infarction evaluation with sequential MR imaging", 172, pp.17982~ (1989)
- Kuhn MJ, "evaluation with MR imaging", 168
- Forester M, "The effects of wallerian degeneration of the optic radiations demonstrated by MRI", 34, pp.323325~ (1992), D'Incerti L and Farina L
- Rabin BM, "Distal neuronal degeneration caused by intracranial lesions", 171(1), pp.95102~ (1998)
- Yamada K, "MR imaging of CNS tractopathy: wallerian and transneuronal degeneration", 171(3), pp.813~818 (1998)
- Wiklund LM, "correlation between CT morphology and clinical findings", 33, pp.512533~ (1991)
- Polak JF, "Wallerian degeneration demonstrated by magnetic resonance spectroscopic measurements on peripheral nerves", 152, pp.8587~ (1984)
- De Simone T, "Wallerian degeneration of the pontocerebellar fibers", 26(5), pp.1062~1065 (2005)
- Mazumdar A, "Diffusion-weighted imaging of acute corticospinal tract injury preceding Wallerian degeneration in the maturing human brain", 24(5), pp.1057~1066 (2003)
- Pierpaoli C, "Water diffusion changes in Wallerian degeneration and their dependence on white matter architecture", 13(6), pp.1174~1185 (2001)
- Werring DJ, "Diffusion tensor imaging can detect and quantify corticospinal tract degeneration after stroke", 69(2), pp.269~272 (2001)
- Virta A, "Visualizing and characterizing white matter fiber structure and architecture in the human pyramidal tract using diffusion tensor MRI", 17(8), pp.1121~1133 (1999)
- Thomalla G, "Diffusion tensor imaging detects early Wallerian degeneration of the pyramidal tract after ischemic stroke", 22(4), pp.1767~1774 (2004)
- Mattiello J, "Estimation of the effective self-diffusion tensor from the NMR spin echo", 103, pp.247254~ (1994)
- Xu D, "A framework for callosal fiber distribution analysis", 17(3), pp.1131~1143 (2002)
- Corouge I, "Fiber tract-oriented statistics for quantitative diffusion tensor MRI analysis", 3749, pp.131~139 (2005)
- Fillard, P, "Quantitative analysis of white matter properties along geodesic paths", 2879, pp.16~23 (2003)
- Taoka T, "Diffusion anisotropy and diffusivity of white matter tracts within the temporal stem in Alzheimer disease: evaluation of the "tract of interest" by diffusion tensor tractography", 27(5), pp.1040~1045 (2006)
- Evans, "3D statistical neuroanatomical models from 305 MRI volumes", 3 (1993)
- Mori S, "Three dimensional tracking of axonal projections in the brain by magnetic resonance imaging", 45(2), pp.265~269 (1999)
- Yamada K, "Wallerian degeneration of the inferior cerebellar peduncle depicted by diffusion weighted imaging", 74(7), pp.977~978 (2003)
- Meguro K, "Atrophy of the corpus callosum correlates with white matter lesions in patients with cerebral ischaemia", 42(7), pp.413~419 (2000)
- Ahmed A, "When is facial paralysis Bell palsy? Current diagnosis and treatment unilateral central facial weakness", 72(5), pp.398~405 (2005)
- Shimony JS, "Quantitative diffusion-tensor anisotropy imaging: normative human data and anatomic analysis", 212(3), pp.770~784 (1999)