Shape Analysis of the Subcortical Nuclei in Amyotrophic Lateral Sclerosis without Cognitive Impairment
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Background and Purpose Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that mainly affects the pyramidal motor system. However, recent studies have suggested that degeneration of the extramotor system plays a role in the disability experienced by patients with ALS. We investigated the local shape changes and mean volumes of the subcortical nuclei in sporadic ALS patients with preserved cognition. Methods The participants comprised 32 patients with ALS and 43 age- and sex-matched healthy controls. Three-dimensional T1-weighted structural images were acquired. Surfacebased vertex analysis was performed with fully automated segmentation of both amygdalae, hippocampi, caudate nuclei, nuclei accumbens, putamina, pallida, and thalami, and the brainstem. The scalar distances from the mean surfaces of the individual subcortical nuclei were compared between groups, and correlations of the local shape distances with initial Amyotrophic Lateral Sclerosis Functional Rating Scale Revised (ALS-FRS-R) scores and the delta FRS-R and with the disease duration were analyzed. Results ALS patients showed regional shape contractions on the lateral surfaces of both pallida, the lateroposterior surface of the right putamen, and the anterior basal surface of the right accumbens. Delta FRS-R scores were negatively correlated with local shape distances in the right hippocampus and the putamina. However, the initial ALS-FRS-R score and disease duration were not correlated with local shape distances. Conclusions Subcortical gray-matter structures are involved in the neurodegenerative process of ALS before cognitive impairment becomes evident.
Abstract
Background and Purpose Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that mainly affects the pyramidal motor system. However, recent studies have suggested that degeneration of the extramotor system plays a role in the disability experienced by patients with ALS. We investigated the local shape changes and mean volumes of the subcortical nuclei in sporadic ALS patients with preserved cognition. Methods The participants comprised 32 patients with ALS and 43 age- and sex-matched healthy controls. Three-dimensional T1-weighted structural images were acquired. Surfacebased vertex analysis was performed with fully automated segmentation of both amygdalae, hippocampi, caudate nuclei, nuclei accumbens, putamina, pallida, and thalami, and the brainstem. The scalar distances from the mean surfaces of the individual subcortical nuclei were compared between groups, and correlations of the local shape distances with initial Amyotrophic Lateral Sclerosis Functional Rating Scale Revised (ALS-FRS-R) scores and the delta FRS-R and with the disease duration were analyzed. Results ALS patients showed regional shape contractions on the lateral surfaces of both pallida, the lateroposterior surface of the right putamen, and the anterior basal surface of the right accumbens. Delta FRS-R scores were negatively correlated with local shape distances in the right hippocampus and the putamina. However, the initial ALS-FRS-R score and disease duration were not correlated with local shape distances. Conclusions Subcortical gray-matter structures are involved in the neurodegenerative process of ALS before cognitive impairment becomes evident.
참고문헌 (38)
- Kiernan MC, "Amyotrophic lateral sclerosis", Lancet, 377, pp.942~955 (2011)
- van der Graaff MM, "Upper motor neuron and extra-motor neuron involvement in amyotrophic lateral sclerosis : a clinical and brain imaging review", Neuromuscul Disord, 19, pp.53~58 (2009)
- Grolez G, "The value of magnetic resonance imaging as a biomarker for amyotrophic lateral sclerosis : a systematic review", BMC Neurol, 16, pp.155~ (2016)
- Christidi F, "Clinical and radiological markers of extra-motor deficits in amyotrophic lateral sclerosis", Front Neurol, 9, pp.1005~ (2018)
- Proudfoot M, "Imaging cerebral activity in amyotrophic lateral sclerosis", Front Neurol, 9, pp.1148~ (2019)
- Bock M, "Cognitive-behavioral changes in amyotrophic lateral sclerosis : screening prevalence and impact on patients and caregivers", Amyotroph Lateral Scler Frontotemporal Degener, 17, pp.366~373 (2016)
- Pradat PF, "Extrapyramidal stiffness in patients with amyotrophic lateral sclerosis", Mov Disord, 24, pp.2143~2148 (2009)
- Desai J, "Extrapyramidal involvement in amyotrophic lateral sclerosis : backward falls and retropulsion", J Neurol Neurosurg Psychiatry, 67, pp.214~216 (1999)
- Geser F, "Evidence of multisystem disorder in whole-brain map of pathological TDP-43 in amyotrophic lateral sclerosis", Arch Neurol, 65, pp.636~641 (2008)
- Brettschneider J, "Stages of pTDP-43 pathology in amyotrophic lateral sclerosis", Ann Neurol, 74, pp.20~38 (2013)
- 태우석, "Current Clinical Applications of Diffusion-Tensor Imaging in Neurological Disorders", Journal of Clinical Neurology, 14(2), pp.129~140 (2018), 대한신경과학회[DOI]
- Takahashi H, "Evidence for a dopaminergic deficit in sporadic amyotrophic lateral sclerosis on positron emission scanning", Lancet, 342, pp.1016~1018 (1993)
- IPT single photon emission computed tomography, "J Neurol Neurosurg Psychiatry", 1998, 263~265
- Bede P, "Basal ganglia involvement in amyotrophic lateral sclerosis", Neurology, 81, pp.2107~2115 (2013)
- Westeneng HJ, "Subcortical structures in amyotrophic lateral sclerosis", Neurobiol Aging, 36, pp.1075~1082 (2015)
- Bede P, "Brainstem pathology in amyotrophic lateral sclerosis and primary lateral sclerosis : a longitudinal neuroimaging study", Neuroimage Clin, 24, pp.102054~ (2019)
- Machts J, "Basal ganglia pathology in ALS is associated with neuropsychological deficits", Neurology, 85, pp.1301~1309 (2015)
- Brooks BR, "El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis", Amyotroph Lateral Scler Other Motor Neuron Disord, 1, pp.293~299 (2000)
- Strong MJ, "Amyotrophic lateral sclerosis-frontotemporal spectrum disorder (ALS-FTSD): revised diagnostic criteria", Amyotroph Lateral Scler Frontotemporal Degener, 18, pp.153~174 (2017)
- Sabatelli M, "Natural history of young-adult amyotrophic lateral sclerosis", Neurology, 71, pp.876~881 (2008)
- 김현영, "한글판 Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised : 신뢰도와 타당도에 관한 예비연구", 대한신경과학회지, 25(2), pp.149~154 (2007), 대한신경과학회
- Kang Y, "Seoul Neuropsychological Screening Battery" (2003), Human Brain Research & Consulting Co
- Kang SJ, "Caregiver-administered neuropsychiatric inventory (CGA-NPI)", J Geriatr Psychiatry Neurol, 17, pp.32~35 (2004)
- Rascovsky K, "Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia", Brain, 134, pp.2456~2477 (2011)
- Jenkinson M, "FSL", Neuroimage, 62, pp.782~790 (2012)
- Winkler AM, "Permutation inference for the general linear model", Neuroimage, 92, pp.381~397 (2014)
- Salimi-Khorshidi G, "Adjusting the effect of nonstationarity in cluster-based and TFCE inference", Neuroimage, 54, pp.2006~2019 (2011)
- Benjamini Y, "Controlling the false discovery rate : a practical and powerful approach to multiple testing", J R Stat Soc B, 57, pp.289~300 (1995)
- Alexander GE, "Parallel organization of functionally segregated circuits linking basal ganglia and cortex", Annu Rev Neurosci, 9, pp.357~381 (1986)
- Pupillo E, "Extrapyramidal and cognitive signs in amyotrophic lateral sclerosis : a population based cross-sectional study", Amyotroph Lateral Scler Frontotemporal Degener, 16, pp.324~330 (2015)
- McCluskey L, "ALS-Plus syndrome : non-pyramidal features in a large ALS cohort", J Neurol Sci, 345, pp.118~124 (2014)
- Gilbert RM, "Parkinsonism and motor neuron diseases : twenty-seven patients with diverse overlap syndromes", Mov Disord, 25, pp.1868~1875 (2010)
- Murakami N, "Parkinsonism-dementia complex on Guam-overview of clinical aspects", J Neurol, 246(Suppl 2), pp.II16~II18 (1999)
- Yase Y, "Kii ALS dementia", Neuropathology, 21, pp.105~109 (2001)
- Feron M, "Extrapyramidal deficits in ALS : a combined biomechanical and neuroimaging study", J Neurol, 265, pp.2125~2136 (2018)
- Christidi F, "Hippocampal pathology in amyotrophic lateral sclerosis : selective vulnerability of subfields and their associated projections", Neurobiol Aging, 84, pp.178~188 (2019)
- Mioshi E, "Neuropsychiatric changes precede classic motor symptoms in ALS and do not affect survival", Neurology, 82, pp.149~155 (2014)
- Tremblay L, "Selective dysfunction of basal ganglia subterritories : from movement to behavioral disorders", Mov Disord, 30, pp.1155~1170 (2015)