Seroprevalence of Toxoplasma gondii Assayed Using Rapid Diagnostic Tests among Residents in Three Counties Adjacent to the Demilitarized Zone, Korea
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Toxoplasma gondii seroprevalence have been rapidly increasing in some parts of Korea. We analyzed prevalence of anti-Toxoplasma gondii antibodies, using a rapid diagnostic test (RDT), in the sera of 552 residents in Ganghwa-gun, 661 ones in Cheorwon-gun, and 305 ones in Goseong-gun, Korea in 2019. IgG/IgM RDT mounted with recombinant fragment of major surface antigen (SAG1), glutathione-S-transferase-linker-SAG1A, were applied to the sera. IgG seroprevalence was 28.1% in Ganghwa-gun, 19.5% in Cheorwon-gun and 35.7% in Goseong-gun. Odds ratios comparing Cheorwon vs Ganghwa was 0.63 (P=0.001) and Goesong versus Ganghwa was 1.47 (P=0.01) adjusting age and sex. Goseong had highest seroprevalence among the 3 counties both in crude rates and logistic regression. Although Cheorwon and Goseong are adjacent to the demilitarized zone (DMZ) in Korea, seroprevalence rate was much higher in Goseong. Further investigation on other DMZ-closed areas is necessary whether they have high prevalence rates compared to the other areas. T. gondii prevalence in Korea is still persists; proper health policy should be established.
Abstract
Toxoplasma gondii seroprevalence have been rapidly increasing in some parts of Korea. We analyzed prevalence of anti-Toxoplasma gondii antibodies, using a rapid diagnostic test (RDT), in the sera of 552 residents in Ganghwa-gun, 661 ones in Cheorwon-gun, and 305 ones in Goseong-gun, Korea in 2019. IgG/IgM RDT mounted with recombinant fragment of major surface antigen (SAG1), glutathione-S-transferase-linker-SAG1A, were applied to the sera. IgG seroprevalence was 28.1% in Ganghwa-gun, 19.5% in Cheorwon-gun and 35.7% in Goseong-gun. Odds ratios comparing Cheorwon vs Ganghwa was 0.63 (P=0.001) and Goesong versus Ganghwa was 1.47 (P=0.01) adjusting age and sex. Goseong had highest seroprevalence among the 3 counties both in crude rates and logistic regression. Although Cheorwon and Goseong are adjacent to the demilitarized zone (DMZ) in Korea, seroprevalence rate was much higher in Goseong. Further investigation on other DMZ-closed areas is necessary whether they have high prevalence rates compared to the other areas. T. gondii prevalence in Korea is still persists; proper health policy should be established.
참고문헌 (23)
- Black MW, "Lytic cycle of Toxoplasma gondii", Microbiol Mol Biol Rev, 64, pp.607~623 (2000)[DOI]
- Furtado JM, "Toxoplasmosis: a global threat", J Glob Infect Dis, 3, pp.281~284 (2011)[DOI]
- Tenter AM, "Toxoplasma gondii: from animals to humans", Int J Parasitol, 30, pp.1217~1258 (2000)[DOI]
- Montoya JG, "Management of Toxoplasma gondii infection during pregnancy", Clin Infect Dis, 47, pp.554~566 (2008)[DOI]
- 송경주, "Seroprevalence of toxoplasmosis in Korean pregnant women", The Korean Journal of Parasitology, 43(2), pp.69~71 (2005), 대한기생충학ㆍ열대의학회[DOI]
- Weiss LM, "Toxoplasmosis: A history of clinical observations", Int J Parasitol, 39, pp.895~901 (2009)[DOI]
- Choi WY, "Foodborne outbreaks of human toxoplasmosis", J Infect Dis, 17, pp.1280~1282 (1997)[DOI]
- Kim MH, "A toxoplasmic uveitis case of a 60-year-old male in Korea", Korean J Parasitol, 38, pp.29~31 (2000)[DOI]
- 박영훈, "Clinical Features of Ocular Toxoplasmosis in Korean Patients", The Korean Journal of Parasitology, 49(2), pp.167~171 (2011), 대한기생충학ㆍ열대의학회
- Choi WY, "Toxoplasma antibody titers by indirect latex agglutination test in patients of Kangnam St. Mary's Hospital and Cheju Medical Center", Korean J Parasitol, 27, pp.171~175 (1989)[DOI]
- Choi WY, "Detection of antibodies in serum and cerebrospinal fluid to Toxoplasma gondii by indirect latex agglutination test and enzyme-linked immunosorbent assay", Korean J Parasitol, 30, pp.83~90 (1992)[DOI]
- 홍성종, "Maintained Seroprevalence of Toxoplasmosis among the Residents of Jeju Island, Korea", The Korean Journal of Parasitology, 49(3), pp.309~311 (2011), 대한기생충학ㆍ열대의학회
- Yang HJ, "eroprevalence of toxoplasmosis in the residents of Cheju island, Korea", Korean J Parasitol, 38, pp.91~93 (2000)[DOI]
- 안혜진, "Seroprevalence of Toxoplasmosis in the Residents of Cheorwon-gun, Gangwon-do, Korea", The Korean Journal of Parasitology, 50(3), pp.225~227 (2012), 대한기생충학ㆍ열대의학회
- Zhaoshou Yang, "A Surge in the Seroprevalence of Toxoplasmosis among the Residents of Islands in Gangwha-gun, Incheon, Korea", The Korean Journal of Parasitology, 50(3), pp.191~197 (2012), 대한기생충학ㆍ열대의학회
- 김영훈, "Seroprevalence of Toxoplasmosis with ELISA and Rapid Diagnostic Test among Residents in Gyodong-do, Inchon city, Korea: A Four-Year Follow-up", The Korean Journal of Parasitology, 55(3), pp.247~254 (2017), 대한기생충학ㆍ열대의학회
- 김영훈, "Seroprevalence of Toxoplasmosis Detected by RDT in Residents near the DMZ (demilitarized zone) of Cheorwon-gun, Gangwon-do, Korea", The Korean Journal of Parasitology, 55(4), pp.385~389 (2017), 대한기생충학ㆍ열대의학회
- 김영훈, "High Seroprevalence of Toxoplasmosis Detected by RDT among the Residents of Seokmo-do (Island) in Ganghwa-Gun, Incheon City, Korea", The Korean Journal of Parasitology, 55(1), pp.9~13 (2017), 대한기생충학ㆍ열대의학회
- Sohn WM, "Western blot analysis of stray cat sera against Toxoplasma gondii and the diagnostic availability of monoclonal antibodies in sandwich-ELISA", Korean J Parasitol, 37, pp.249~256[DOI]
- 송경주, "A Rapid Diagnostic Test for Toxoplasmosis using Recombinant Antigenic N-terminal Half of SAG1 Linked with Intrinsically Unstructured Domain of GRA2 Protein", The Korean Journal of Parasitology, 51(5), pp.503~510 (2013), 대한기생충학ㆍ열대의학회
- Soh CT, "Latent infection by Toxoplasma gondii in Korea", Yonsei Med J, 1, pp.52~54 (1960)[DOI]
- Dubey JP, "High prevalence and genotypes of Toxoplasma gondii isolated from organic pigs in northern USA", Vet Parasitol, 188, pp.14~18 (2012)[DOI]
- Meerburg BG, "Neospora caninum and Toxoplasma gondii in brain tissue of feral rodents and insectivores caught on farms in the Netherlands", Vet Parasitol, 184, pp.317~320 (2012)[DOI]