노인의 인지감퇴에 미치는 아포지단백 E4와 교육수준의 상호작용
Interaction of Apolipoprotein E ε4 and Education on Cognitive Decline in Korean Elders
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Objective: This study aimed to test potential modifying effects of education on the association between apolipoprotein E ε4 (Apo E4) and cognitive decline.Methods: A community cohort (N=683) aged 65 or over completed the Korean version of Mini-Mental State Examination (MMSE-K) at baseline and two years later (1999-2001). Apo E polymorphism was genotyped, and classified into with or without Apo E4. Educational levels were categorized to have or no education. Covariates included demographic (age, gender), life style (smoking, alcohol drinking), clinical (depression, sleep disorder, vascular risk factors) characteristics.Results: The association between Apo E4 and cognitive decline was significant only in the old persons with no education. The interaction term between education and Apo E4 on cognitive decline was significant (p=0.040).Conclusion: Elders with no education might be more vulnerable to the impact of Apo E4 on cognitive decline, which suggests gene-environment interaction.
Abstract
Objective: This study aimed to test potential modifying effects of education on the association between apolipoprotein E ε4 (Apo E4) and cognitive decline.Methods: A community cohort (N=683) aged 65 or over completed the Korean version of Mini-Mental State Examination (MMSE-K) at baseline and two years later (1999-2001). Apo E polymorphism was genotyped, and classified into with or without Apo E4. Educational levels were categorized to have or no education. Covariates included demographic (age, gender), life style (smoking, alcohol drinking), clinical (depression, sleep disorder, vascular risk factors) characteristics.Results: The association between Apo E4 and cognitive decline was significant only in the old persons with no education. The interaction term between education and Apo E4 on cognitive decline was significant (p=0.040).Conclusion: Elders with no education might be more vulnerable to the impact of Apo E4 on cognitive decline, which suggests gene-environment interaction.
참고문헌 (30)
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