노인인구에서 ApoE 유전자형에 따른 머리둘레와 인지기능간의 연관성
Correlation between Head Circumference and Cognition in the Elderly by ApoE Genotype
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초록
본 연구는 지역사회에 거주하고 있는 60세 이상 1152명의 노인들을 대상으로ApoE 대립유전자형에 따른 머리둘레와 인지기능 사이의 관계를 알아보고자 하였다. 연구 결과 나이, 성별, 교육수준, ApoE ε4 대립유전자 유무, 현재 음주 및 흡연 여부를 보정하였을 때 머리둘레가 작아질수록 K-MMSE 점수가 유의하게 감소하는 소견을 보였으며, 나이, 성별, 교육수준, 키, 현재 음주 및 흡연 여부를 보정하였을 때 머리둘레가 가장 작은 1분위 집단에서만 ApoE ε4 대립유전자가 양성일 때 K-MMSE가 유의하게 감소하였다. 이는 뇌 예비력을 반영하는 머리둘레가 인지기능과 관련이 있고, ApoE ε4 대립유전자가 이에 영향을 미칠 가능성을 시사한다고 할 수 있다.
Abstract
Objectives: The aim of this study is to find out the effect of ApoE genotype on correlation between head circumference and cognition of the elderly in community. Methods: A total of 1,152 subjects (380 men and 772 women) aged 60-91 years were analyzed from preliminary data of GDEMCIS (Gwangju Dementia and MCI Study). The study questionnaire consisted of demographic characteristics, current and past illness history, drug history, K-MMSE (Korean version-Mini Mental State Examination). We also measured head circumference and examined ApoE genotype. Results: On regression analysis, as head circumference become smaller, K-MMSE scores decreased adjusted by age, sex, educational level, ApoE ε4 allele, current smoking and alcohol drinking (β=0.15, p=0.04). Only in the lowest quartile group, presence of ApoE ε4 allele reduced K-MMSE scores adjusted by age, sex, educational level, height, current alcohol drinking and smoking status (β=-1.39, p=0.008). Conclusion: These results suggest that head circumference may have influence on K-MMSE scores, and presence of ApoE ε4 allele may mediate an effect on it.
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