일 지역사회거주 치매의심 노인에서 apolipoprotein E ε4와 인지기능 간의 연관성
An association between apolipoprotein E ε4 and cognitive functionin community-dwelling elders with questionable dementia
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초록
Introduction: It was the aim of the present paper to examine the impact of the apolipoprotein E (APOE) ε4 on cognitive performance in community-dwelling elderly samples with 'questionable dementia'.Methods: Total 295 samples diagnosed with 'questionable dementia' in the recent year and completed the Korean version of the Consortium Establish a Registry for Alzheimer's Disease (CERAD-K) neuropsychological assessment protocol, were recruited. The CDR test established score of 0.5. Genomic DNA was extracted from the venous blood and APOE genotyping was done in this group. Their cognitive performance was compared by the occurrence of the APOE ε4 allele. Results: The impact of ε4 allele was significant in the Word List Recall Test (WLRT, F=4.511, df=1, p=0.035). The 'young-old' group aged 75 years and under had a significantly lower performance on the Word List Recall Test (WLRT, F=5.090, df=1, p=0.015), but the 'old-old' group over 75 years of age had not significantly different performance on the all the item of tests in ε4+ allele group.Conclusion: The conclusion to be drawn here is that community-dwelling elderly samples with ε4 allele in 'questionable dementia' had a significantly lower performance on the Word List Recall Test in the CERAD-K neuropsychological test batteries and the effect was prominent in 'youg-old' age group.
Abstract
Introduction: It was the aim of the present paper to examine the impact of the apolipoprotein E (APOE) ε4 on cognitive performance in community-dwelling elderly samples with 'questionable dementia'.Methods: Total 295 samples diagnosed with 'questionable dementia' in the recent year and completed the Korean version of the Consortium Establish a Registry for Alzheimer's Disease (CERAD-K) neuropsychological assessment protocol, were recruited. The CDR test established score of 0.5. Genomic DNA was extracted from the venous blood and APOE genotyping was done in this group. Their cognitive performance was compared by the occurrence of the APOE ε4 allele. Results: The impact of ε4 allele was significant in the Word List Recall Test (WLRT, F=4.511, df=1, p=0.035). The 'young-old' group aged 75 years and under had a significantly lower performance on the Word List Recall Test (WLRT, F=5.090, df=1, p=0.015), but the 'old-old' group over 75 years of age had not significantly different performance on the all the item of tests in ε4+ allele group.Conclusion: The conclusion to be drawn here is that community-dwelling elderly samples with ε4 allele in 'questionable dementia' had a significantly lower performance on the Word List Recall Test in the CERAD-K neuropsychological test batteries and the effect was prominent in 'youg-old' age group.
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