병적 도박 환자에서의 회백질 부피 변화 분석: 화소 기반 형태분석 방법을 이용한 예비 연구
Gray Matter Changes in Patients with Pathological Gambling: A Preliminary Study using Voxel-Based Morphometry Study
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Objectives: The purpose of this study was to examine structural abnormalities of brain in patients with pathological gambling (PG) using voxel-based morphometry. Methods: We compared gray matter (GM) volumes between 10 patients with PG and 14 age- and IQ-matched healthy controls and examined the relationship of GM volumes with clinical variables in patients with PG. Results: We found significant increase of GM volume in the superior, middle, and inferior frontal gyrus, the midbrain, the middle temporal gyrus, the precuneus, and the fusiform gyrus of patients with PG. A significant decrease of GM volume was observed in the parahippocampal gyrus and the lingual gyrus of the patient group. In addition, GM volumes in some of these regions were positively associated with South Oaks Gambling Screen score and negatively with age of onset in patients with PG. Conclusions: Current findings indicate that structural abnormalities in the fronto-temporal cortex, the midbrain, and the precuneus might be involved in the pathophysiology of PG, and contribute to some of the behavioral changes observed in patients with PG.
Abstract
Objectives: The purpose of this study was to examine structural abnormalities of brain in patients with pathological gambling (PG) using voxel-based morphometry. Methods: We compared gray matter (GM) volumes between 10 patients with PG and 14 age- and IQ-matched healthy controls and examined the relationship of GM volumes with clinical variables in patients with PG. Results: We found significant increase of GM volume in the superior, middle, and inferior frontal gyrus, the midbrain, the middle temporal gyrus, the precuneus, and the fusiform gyrus of patients with PG. A significant decrease of GM volume was observed in the parahippocampal gyrus and the lingual gyrus of the patient group. In addition, GM volumes in some of these regions were positively associated with South Oaks Gambling Screen score and negatively with age of onset in patients with PG. Conclusions: Current findings indicate that structural abnormalities in the fronto-temporal cortex, the midbrain, and the precuneus might be involved in the pathophysiology of PG, and contribute to some of the behavioral changes observed in patients with PG.
참고문헌 (28)
- Shaffer HJ, "Estimating the prevalence of disordered gambling behavior in the United States and Canada: a research synthesis", Am J Public Health, 89(9), pp.1369~1376 (1999)
- Potenza MN, "Should addictive disorders include non-substance-related conditions?", Addiction, 101(1), pp.142~151 (2006)
- Petry NM, "Comorbidity of DSM-IV pathological gambling and other psychiatric disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions", J Clin Psychiatry, 66(5), pp.564~574 (2005)
- Eisen SA, "The genetics of pathological gambling", Semin Clin Neuropsychiatry, 6(3), pp.195~204 (2001)
- Ibanez A, "Genetics of pathological gambling", J Gambl Stud, 19(1), pp.11~22 (2003)
- Hollander E, "Pharmacological treatments of pathological gambling", J Gambl Stud, 21(1), pp.99~110 (2005)
- Petry NM, "Should the scope of addictive behaviors be broadened to include pathological gambling?", Addiction, 101(1), pp.152~160 (2006)
- Hollander E, "Obsessive-compulsive spectrum disorders", J Clin Psychiatry, 56(4), pp.3~6 (1995)
- Mechtcheriakov S, "A widespread distinct pattern of cerebral atrophy in patients with alcohol addiction revealed by voxel-based morphometry", J Neurol Neurosurg Psychiatry, 78(6), pp.610~614 (2007)
- Franklin TR, "Decreased gray matter concentration in the insular, orbitofrontal, cingulate, and temporal cortices of cocaine patients", Biol Psychiatry, 51(2), pp.134~142 (2002)
- Kwon JS, "Neuroimaging in obsessive-compulsive disorder", Expert Rev Neurother, 9(2), pp.255~269 (2009)
- Chamberlain SR, "Grey matter abnormalities in trichotillomania: morphometric magnetic resonance imaging study", Br J Psychiatry, 193(3), pp.216~221 (2008)
- First MB, "Structured clinical interview for DSM-IV axis I disorder" (1996), New York State Psychiatric Institute
- Lesieur HR, "The South Oaks Gambling Screen (SOGS): a new instrument for the identification of pathological gamblers", Am J Psychiatry, 144(9), pp.1184~1188 (1987)
- Pallanti S, "Reliability and validity of the pathological gambling adaptation of the Yale-Brown Obsessive-Compulsive Scale (PG-YBOCS)", J Gambl Stud, 21(4), pp.431~443 (2005)
- Robbins TW, "From arousal to cognition: the integrative position of the prefrontal cortex", Prog Brain Res, 126, pp.469~483 (2000)
- Cavedini P, "D'Annucci A, Bellodi L. Frontal lobe dysfunction in pathological gambling patients", Biol Psychiatry, 51(4), pp.334~341 (2002)
- Goudriaan AE, "Pathological gambling: a comprehensive review of biobehavioral findings", Neurosci Biobehav Rev, 28(2), pp.123~141 (2004)
- Kertzman S, "Stroop performance in pathological gamblers", Psychiatry Res, 142(1), pp.1~10 (2006)
- Roca M, "Executive functions in pathologic gamblers selected in an ecologic setting", Cogn Behav Neurol, 21(1), pp.1~4 (2008)
- So Young Yoo, "Voxel-Based Morphometry Study of Gray Matter Abnormalities in Obsessive-Compulsive Disorder", Journal of Korean Medical Science, 23(1), pp.24~30 (2008), 대한의학회
- Nestler EJ, "Molecular and cellular basis of addiction", Science, 278(5335), pp.58~63 (1997)
- Olds ME, "The central basis of motivation: intracranial self-stimulation studies", Annu Rev Psychol, 32, pp.523~574 (1981)
- Reuter J, "Pathological gambling is linked to reduced activation of the mesolimbic reward system", Nat Neurosci, 8(2), pp.147~148 (2005)
- raclopride, "Syna", 2004, 65~71
- Smolka MN, "Severity of nicotine dependence modulates cue-induced brain activity in regions involved in motor preparation and imagery", Psychopharmacology, 184(3), pp.577~588 (2006)
- Boettiger CA, "Immediate reward bias in humans: fronto-parietal networks and a role for the Catechol-O-Methyltransferase 158Val", Val genotype, 2007, pp.27(52), 14383~14391
- Pohjalainen T, "Sex differences in the striatal dopamine D2 receptor binding characteristics in vivo", Am J Psychiatry, 155(6), pp.768~773 (1998)