화소 기반 형태분석 방법을 이용한 알츠하이머 치매환자의 회백질 용적감소의 정량적 분석
A Voxel-based Morphometry of Gray matter Reduction in Patients with Dementia of the Alzheimer's type
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Objective: The purpose of this study were to find brain regions in which gray matter volume was reduced and to show the capability of voxel-based morphpmetry (VBM) analysis for lateralizing clinically significant brain regions in dementia of Alzheimer's type patients compared to healthy group. Method: MR T1-weighted images of the 20 dementia of Alzheimer's type patients were compared with those of the 20 normal controls. Images were transformed to standard MNI space. In order to observe gray matter volume change. Gray matter was smoothed with a Gaussian kernel. After these preprocessing, statistical analysis was performed using statistical parametric mapping software (SPM2). Results: Gray matter volume was significantly reduced in the both side parahippocampal gyrus, Lt. anterior cingulate gyrus, Lt. posterior cingulate gyrus, both side superior temporal gyrus, Lt. middle temporal gyrus, Lt. superior, Both side middle, Rt. anterior frontal gyrus and Rt. precuneus in dementia of Alzheimer's type patient group. Conclusions: These VBM results confirm previous findings of temporal lobe and limbic lobe atrophic changes in dementia of Alzheimer's type, and suggest that these abnormalities may be confined to specific sites within that lobe, rather than showing a widespread distribution.
Abstract
Objective: The purpose of this study were to find brain regions in which gray matter volume was reduced and to show the capability of voxel-based morphpmetry (VBM) analysis for lateralizing clinically significant brain regions in dementia of Alzheimer's type patients compared to healthy group. Method: MR T1-weighted images of the 20 dementia of Alzheimer's type patients were compared with those of the 20 normal controls. Images were transformed to standard MNI space. In order to observe gray matter volume change. Gray matter was smoothed with a Gaussian kernel. After these preprocessing, statistical analysis was performed using statistical parametric mapping software (SPM2). Results: Gray matter volume was significantly reduced in the both side parahippocampal gyrus, Lt. anterior cingulate gyrus, Lt. posterior cingulate gyrus, both side superior temporal gyrus, Lt. middle temporal gyrus, Lt. superior, Both side middle, Rt. anterior frontal gyrus and Rt. precuneus in dementia of Alzheimer's type patient group. Conclusions: These VBM results confirm previous findings of temporal lobe and limbic lobe atrophic changes in dementia of Alzheimer's type, and suggest that these abnormalities may be confined to specific sites within that lobe, rather than showing a widespread distribution.
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