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논문KCI 등재

사회공포증과 세로토닌 수송체 유전자다형성과의 연관성 : 예비연구

Association between Social Phobia and Serotonin Transporter Gene Polymorphism: Preliminary Study

이민수|오강섭|임세원|이재헌
대한생물정신의학회 (The Korean Society Of Biological Psychiatry)|2006.08|생물정신의학 (Journal of Korean Society of Biological Psychiatry)|제13권 제3호|pp. 170-177

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참고문헌

주제분류정신과학

초록

Abstract

Objectives : Disturbances of serotonergic system might be related to the possible mechanism of social phobia. This study was to investigate the association of serotonin transporter gene and social phobia.Methods : Sixty nine patients with social phobia(51 male (73.9%), mean age 35.17±11.89 years) and seventy four normal controls (54 male (73.0%), mean age 33.46±9.63 years) were tested for serotonin transporter gene-linked polymorphic region(5-HTTLPR) polymorphism. Additionally, patients were grouped into 46 generalized(GEN) and 23 nongeneralized(NGEN) subgroups and 5-HTTLPR polymorphism was compared with that of normal controls. The genotypes and allele frequencies of the 5-HTTLPR polymorphism between social phobia and the control group were compared. Genomic DNA was extracted from their blood and 5-HTTLPR polymorphisms were determined by using polymerase chain reaction. Results : Significant association was observed between the S(ss) genotype and social phobia, by functional classification(p=.010). In allele frequency analysis, a significant association was also observed between the short allele and social phobia(p=.030). A significant associations between S genotype and each subgroup were observed(GEN p=.045 ; NGEN p=.033), but there were no differences in allele frequency. And, no differences in genotype and allele distribution between two subgroups were found.Conclusion : The results in our Korean sample suggest that S genotype of 5-HTTLPR may be associated with social phobia and s allele may be an important genetic factor that activates social phobic symptoms. But, further studies including large number of samples are necessary to elucidate these present findings.

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관련 논문AI추천

한국인에서의 도파민 수용체 유전자 다형성(Dopamine Transporter Gene(DAT1) Polymorphism)과 사회공포증과의 연관성에 관한 예비 연구오강섭, 윤형근, 이민수대한생물정신의학회 · 생물정신의학2004 · 제11권 제2호한국인 사회공포증 환자에서 도파민 D2 수용체 TaqI A 유전자 다형성:예비연구김범조, 신동원, 오강섭, 이민수, 임세원대한생물정신의학회 · 생물정신의학2007 · 제14권 제2호강박장애와 세로토닌 수송체 유전자다형성과의 관련성김세주, 김찬형, 이홍식, 조대연대한신경정신의학회 · 신경정신의학2005 · 제44권 제1호공황장애와 도파민 수송체 유전자 다형성과의 연관성배승민, 오강섭, 이민수, 임세원대한생물정신의학회 · 생물정신의학2007 · 제14권 제1호한국인 공황장애 환자의 트립토판 가수분해 효소와 세로토닌 전달체 유전자 다형성박헌구, 우종민, 윤경식, 이민수, 조대연, 최영희대한생물정신의학회 · 생물정신의학2004 · 제11권 제2호공황장애에서의 COMT 유전자 다형성 예비연구나철, 우종민, 윤경식, 이영식, 장용이대한신경정신의학회 · 신경정신의학2001 · 제40권 제6호

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