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논문KCI 등재

한국인에서의 도파민 수용체 유전자 다형성(Dopamine Transporter Gene(DAT1) Polymorphism)과 사회공포증과의 연관성에 관한 예비 연구

Polymorphism of Dopamine Transporter Gene(DAT1) in Korean Social Phobia Patients : Preliminary Study

이민수|윤형근|오강섭
대한생물정신의학회 (The Korean Society Of Biological Psychiatry)|2004.11|생물정신의학 (Journal of Korean Society of Biological Psychiatry)|제11권 제2호|pp. 165-172

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키워드

사회공포증·도파민 수송체 유전자(DAT1)·다형성·연합 연구.Social phobia·Dopamine transporter gene(DAT1)·Polymorphism·Association study.
주제분류정신과학

초록

Abstract

Although polymorphism of dopamine transporter gene(DAT1) has been considered to be implicated in the pathogenesis of social phobia, previous investigations have been inconsistent and controversial. The authors investigated the relationship between DAT1 polymorphism and social phobia in Koreans. Methods：DAT1 and alleles of fifty subjects who met DSM-IV criterion of social phobia, and those of age- & sex- matched fifty normal controls in Korea were compared. Additionally, patients were grouped into generalized(33) and nongeneralized(17) types and DAT1 polymorphism was compared with that of age- & sex- matched controls. DAT1 with variable number of tandem repeats(VNTR) were determined by using polymerase chain reaction. To compare the distribution of the DAT1 polymorphism between different groups, Fisher’s exact test was used. Results：There were no significant differences in either genotypic(p=0.451) or allelic(p=0.452) distributions between the social phobia patients and the controls. There also were no differences in genotypic distribution between subtypes of social phobia patients and the controls. Conclusion：We couldn’t find any association between DAT1 polymorphism and social phobia. Further studies including larger number of samples and diverse clinical variables should be conducted to elucidate the present findings

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