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정신분열병과 P50

P50 and Schizophrenia

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참고문헌

주제분류정신과학

초록

Abstract

One of the most widely recognized neurophysiologic endophenotypes for schizophrenia is deficient gating or inhibition of the P50 component of the auditory event-related potential (ERP). A deficit in P50 sensory gating refers to a dysfunction in the mechanism responsible for modulating the brain's sensitivity of filtering out irrelevant or background stimuli, perhaps as a result of dysfunction in inhibitory neural circuits. In this paper, we review the neuronal and genetic aspects as well as medication effects on P50 in schizophrenia.

참고문헌 (72)

  1. "Disorders of attention and perception in early schizophrenia", 34, pp.103~116 (1961)
  2. "Interhemispheric visual masking", 60, pp.495~502 (1985)
  3. "Gating and habituation of the startle reflex in schizophrenic patients", 49, pp.206~215 (1985)
  4. "Neurophysiological evidence for a defect in neuronal mechanisms involved in sensory gating in schizophrenia", 17, pp.639~654 (1982)
  5. "Neurophysiologic studies of sensory gating in schizophrenia:comparison of auditory and visual responses", 20, pp.1284~1296 (1985)
  6. "Sensory physiology and catecholamines in schizophrenia and mania", 31, pp.297~309 (1990)
  7. "Lack of relationship of auditory gating defects to negative symptoms in schizophrenia", 3, pp.131~138 (1990)
  8. "Neurophysiological evidence for a defect in inhibitory pathways in schizophrenia:comparison of medicated and drug-free patients", 18, pp.537~551 (1983)
  9. "Replication and extension of P50 findings in schizophrenia", 22, pp.40~55 (1991)
  10. "Midlatency auditory evoked responses in schizophrenia", 30, pp.430~442 (1991)
  11. "Sensory gating deficits in schizophrenia:new results", 149, pp.488~493 (1992)
  12. "P50 suppression among schizophrenia and normal comparison subjects:a methodological analysis", 41, pp.1035~1044 (1997)
  13. "Startle habituation and sensorimotor gating in schizophrenia and related animal models", 13, pp.64~668 (1987)
  14. "Event-related brain potentials:a window on information processing in schizophrenia", 14, pp.199~203 (1988)
  15. "Sensorimotor gating and schizophrenia:human and animal model studies", 47, pp.181~188 (1990)
  16. "Increased distractibility in schizophrenia patients:electrophysiologic and behavioral evidence", 47, pp.171~179 (1990)
  17. "Gating of the auditory evoked potential in children and adults", 24, pp.223~227 (1987)
  18. "Neurophysiological Studies of sensory gating in schizophrenia", 13, pp.669~678 (1987)
  19. "Elementary neuronal dysfunctions in schizophrenia", 4, pp.233~243 (1991)
  20. "Disorders of attention and perception in early schizophrenia", 34, pp.103~116 (1961)
  21. "Psychological deficit in schizophrenia", 8, pp.275~305 (1963)
  22. "Input dysfunction in schizophrenia Progress in Experimental Personality Research", pp.~47 (1964), Academic Press Inc
  23. "Sensory gating in schizophrenics and normal controls:effects of changing stimulation interval", 25, pp.549~561 (1989)
  24. "Sensory gating deficits in psychiatric inpatients:relation to catecholamine metabolites in different diagnosis group", 27, pp.519~552 (1990)
  25. "Neurophysiological and neuropsychological evidence for attentional dysfunction in schizophrenia", 10, pp.131~141 (1993)
  26. "Gating of auditory evoked responses in normal college students", 19, pp.233~239 (1986)
  27. "codistribution of a sensory gating deficit and schizophrenia in multi-affcted families", 39, pp.257~268 (1991)
  28. "Schizophrenia,sensory gating,and nicotinic receptors", 24, pp.189~202 (1998)
  29. "Sensory gating in a computer model of the CA3 neural network of the hippocampus", 40, pp.1230~1245 (1996)
  30. "The adenosine antagonist theophylline impairs P50 auditory sensory gating in normal subjects", 27, pp.629~637 (2002)
  31. "Normal P50 suppression in schizophrenia patients treated with atypical antipsychotic medications", 157, pp.767~771 (2000)
  32. "Clozapine improves deficient inhibitory auditory processing in DBA", 2 mice, via a nicotinic cholinergic mechanism, 2003, pp.165, 386~396
  33. "Auditory sensory gating and catecholamine metabolism in schizophrenic and normal subjects", 44, pp.21~32 (2003)
  34. "Is P50 suppression a measure of sensory gating in schizophrenia", 43, pp.873~878 (1998)
  35. "Effects of temporal variability on p50 and the gating ratio in schizophrenia:a frequency domain adaptive filter single-trial analysis", 57, pp.57~64 (2000)
  36. "Dopaminergic modulation of the P50 auditory-evoked potential in a computer model of the CA3 region of the hippocampus:its relationship to sensory gating in schizophrenia", 88, pp.265~275 (2003)
  37. "An analysis of the skin conductance orienting response in samples of American,British,and German schizophrenics", 14, pp.155~211 (1982)
  38. "Temporal lobe functioning and electrodermal nonresponding in schizophrenia", l31, pp.159~170 (1992)
  39. "Sensorimotor gating and habituation evoked by electro-cutaneous stimulation", 36, pp.670~679 (1994)
  40. "Habituation of the blink reflex in normals and schizophrenic patients", 19, pp.1~6 (1982)
  41. "Habituation", 77, pp.419~450 (1970)
  42. "Impaired startle prepulse inhibition and habituation in schizotypal patients", 150, pp.1862~1867 (1993)
  43. "Gating of auditory P50 in schizophrenics:unique effects of clozapine", 40, pp.181~188 (1996)
  44. "Auditory P50 in schizophrenics on clozapine:improved gating parallels clinical improvement", 39, pp.10~17 (1999)
  45. "The Brief Psychiatric Rating Scale(BPRS)recent developments in ascertaining and scaling", 24, pp.97~99 (1988)
  46. "Varied effects of atypical neuroleptics on P50 auditory gating in schizophrenia patients", 161, pp.1822~1828 (2004)
  47. "P50 suppression in recent-onset schizophrenia:clinical correlates and risperidone effects", 107, pp.691~698 (1998)
  48. "Olanzapine effects on auditory sensory gating in schizophrenia", 160, pp.2066~2068 (2003)
  49. "Involvement of GABA systems in acetylcholine release induced by 5HT3 receptor blockade in slices from rat entorhinal cortex", 712, pp.274~280 (1996)
  50. "Normalizing effects of nicotine and a novel nicotinic agonist on hippocampal auditory gating in two animal models", 57, pp.869~874 (1997)
  51. "Improved p50 auditory gating with ondansetron in medicated schizophrenia patients", 162, pp.386~388 (2005)
  52. "The endophenotype concept in psychiatry:Etymology and strategic intentions", 160, pp.1~10 (2003)
  53. "Event-related potentials(ERPs)as indicators of risk for schizophrenia", 20, pp.63~74 (1994)
  54. "Deficits in sensory gating in schizophrenic patients and their relatives", 41, pp.607~612 (1984)
  55. "Linkage of a neurological deficit in schizophrenia to a chromosome 15 locus", 94, pp.587~592 (1997)
  56. "Genetic correlation of inhibitory gating of hippocampal auditory response and bungarotoxin-binding nicotinic cholinergic receptors in inbred mouse strain", 15, pp.152~162 (1996)
  57. "Intragastric DMXB-A,an 7 nicotinic agonist,improves deficient sensory inhibition in DBA", 2 mice, 2001, pp.50, 493~500
  58. "Selective alpha7-nicotinic agonists normalize inhibition of auditory response in DBA mice", 136, pp.320~327 (1998)
  59. "Cholinergic gating of response to auditory stimuli in rat hippocampus", 587, pp.130~136 (1992)
  60. "a-Bungarotoxin binding to hippocampal interneurons:immunocytochemical characterization and effects on growth factor expression", 13, pp.1965~1975 (1993)
  61. "Genetic correlation of inhibitory gating of hippocampal auditory evoked response and alpha-bungarotoxin-binding nicotinic cholinergic receptors in inbred mouse strains", 15, pp.152~162 (1996)
  62. "Auditory sensory gating in hippocampal neurons:a model system in the rat", 27, pp.183~192 (1990)
  63. "The activity of hippocampal interneurons and pyramidal cells during the response of the hippocampus to repeated auditory stimuli", 69, pp.371~381 (1995)
  64. "GABA-B antagonists diminish the inhibitory gating of auditory response in the rat hippocampus", 190, pp.133~136 (1995)
  65. "Auditory sensory gating in the rat hippocampus:modulation by brainstem activity", 607, pp.33~38 (1993)
  66. "Inhibition of nitric oxide synthetase disrupts inhibitory gating of auditory responses in rat hippocampus", 287, pp.760~765 (1998)
  67. "Normalization by nicotine of deficient auditory sensory gating in the relatives of schizophrenics", 32, pp.607~616 (1992)
  68. "Normalization of auditory physiology by cigarette smoking in schizophrenic patients", 150, pp.1856~1861 (1993)
  69. "Schizophrenia and nicotinic receptors", 2, pp.179~192 (1994)
  70. "Improvement in smooth pursuit eye movements after cigarette smoking in schizophrenic patients", 18, pp.175~185 (1998)
  71. "Increased levels of nicotine metabolite cotinine in schizophrenic smokers compared to other smokers", 42, pp.1~5 (1997)
  72. "Nicotinic agonists and psychosis", 1, pp.149~162 (2002)

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