논문KCI 등재
정신분열병 환자에서 Clozapine과 그 대사물들의 혈장농도 및 FMO3 유전자 변이
Plasma Concentrations of Clozapine and its Metabolites and FMO3 Variations in Korean Schizophrenic Patients
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
주제분류정신과학
초록
Abstract
Objective: The relationship between the total daily dose of clozapine given and the plasma concentrations of clozapine and its metabolites and the effect of Glu158Lys (wild-type: Glu, 'H'; variant: Lys, 'h') and Glu308Gly (wild-type: Glu, 'D'; variant: Lys, 'd') variation in FMO3 gene on plasma concentrations of clozapine and its metabolites was studied in schizophrenic patients.
참고문헌 (35)
- "Clozapine,a novel antipsychotic agent", 324, pp.746~754 (1991)
- "Clozapine for the treatment-resistant schizophrenic:a double blind comparison with chlorpromazine", 45, pp.789~796 (1988)
- "A prospective study of clozapine in treatment-resistant schizophrenic patients"
- "The history of clozapine", pp.3~5 (1989)
- "Clozapine-induced agranulocytosis", 329, pp.162~167 (1993)
- "Clozapine in tardive dyskinesia:observations from human and animal model studies", 55, pp.102~106 (1994)
- "Clozapine in the treatment of psychotic mood disorders,schizoaffective disorder and schizophrenia", 52, pp.411~414 (1991)
- "Clozapine in severe mood disorder", 56, pp.411~417 (1995)
- "The use of clozapine in severe mood disorder", 55(9), pp.98~101 (1994)
- "Agranulocytosis in patients treated with clozapine", 56, pp.241~248 (1977)
- "Clozapine-induced agranulocytosis:a situation report up to August 1976", 11, pp.199~201 (1977)
- "Leponex-associated granulocytopenia:a review of the situation", 99, pp.118~121 (1989)
- "Clozapine-associated granulocytopenia:a review of the situation", 99 (1992)
- "Mechanism of clozapine-induced agranulocytosis", suppl 1, pp.17~25 (1992)
- "a clozapine metabolite that suppresses hematopoiesis", pp.555~561
- "Microsomal mixed-function amine oxidase:oxidation products of piperazine-substituted phenothiazine drugs", 6, pp.232~239 (1978)
- "A genetic polymorphism of the N-oxidation of trimethylamine in human", 42, pp.588~594 (1987)
- "The molecular biology of the flavin-containing monooxygenases of man", 96, pp.17~32 (1995)
- "Quantitation and kinetic properties of hepatic microsomal and recombinant flavin-containing monooxygenases 3 and 5 from humans", 106, pp.29~45 (1997)
- "Point mutation in flavin-containing monooxygenase 3 gene,FMO3,underlies fish-odour syndrome", 17, pp.491~494 (1997)
- "Characterization of two human flavin-containing monooxygenase(form 3)enzymes expressed in Escherichia Coli as maltose binding protein fusions", 25, pp.1001~1007 (1997)
- "N-Oxygenation of clozapine by flavin-containing monooxygenase", 25, pp.524~527 (1997)
- "Elucidation of individual cytochrome P450 enzymes involved in the metabolism of clozapine", 358, pp.592~599 (1998)
- "Examining concentration-dependent toxicity of clozapine:role of therapeutic drug monitoring", 11, pp.289~301 (2005)
- "Flavin-containing monooxygenase 3 (FMO3) polymorphism in a white population: allele frequencies, mutation linkage, and functional effects on clozapine and caffeine metabolism", 66, pp.431~438 (1999)
- "Phenotypes of flavin-containing monooxygenase activity determined by ranitidine N-oxidation are positively correlated with genotypes of linked FMO3 gene mutations in a Korean population", 10, pp.67~78 (2000)
- "Diagnostic and Statistical Mannual of Mental Disorders", pp.285~286 (1994)
- "Determination of clozapine,norclozapine,and clozapine N-oxide in serum by liquid chromatography", 39, pp.1656~1659 (1993)
- "General pharmacology of clozapine", 160(17), pp.5~11 (1992)
- "Neuroleptic affinities for human brain receptors and their use in predicting adverse effects", 45, pp.331~336 (1984)
- "Dose-related plasma levles of clozapine:influence of smoking behaviour,sex and age", 99 (1989)
- "Pharmacokotherapie und Alter", 25, pp.43~52 (1986)
- "Multiple-dose pharmacokinetics of clozapine in patients", 4, pp.402~405 (1987)
- "Clozapine and norclozapine plasma concentrations and clinical response of treatment-refractory schizophrenic patients", 148, pp.231~235 (1991)
- "Pharmacokinetics and pharmacodynamics of clozapine", 24, pp.161~176 (1993)
관련 논문AI추천
한국 성인 정신분열병 환자의 평균 클로자핀 사용량과 혈중농도에 관한 연구강민희, 김철응, 이경훈, 이윤희대한신경정신의학회 · 신경정신의학2001 · 제40권 제1호한국인 정신분열병 환자에서 CYP2D6*10B 유전자에 관한 연구고재광, 김철응, 노형근, 문혜원, 박창신대한신경정신의학회 · 신경정신의학2001 · 제40권 제6호한국인 조현병 환자에서 클로자핀 처방용량과 혈중농도의 관계 및 이에 영향을 미치는 요인에 관한 연구류승현, 조경형대한조현병학회 · 대한조현병학회지2023 · 제26권 제2호기능성 Catechol-O-Methyltransferase 유전자 다형성과 한국인 정신분열병의 관련성강대희, 김형섭, 박임순, 박태원, 배수영, 윤경식, 최인미, 홍영준대한신경정신의학회 · 신경정신의학2001 · 제40권 제4호한국인 정신분열병 환자 및 정상인에서 기능적 세로토닌 운반체 유전자 다형성 분석이철, 권오주, 김석범, 김정진, 백인호, 이수정, 이창욱대한신경정신의학회 · 신경정신의학2002 · 제41권 제2호Relationship between the Polymorphism of Cytochrome P-450 2D6 and Theclinical Outcomes of Paroxetine in Korean Patients with Depressive DisordersKang Seob Oh, Min Soo Lee대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2003 · 제1권 제1호
이 간행물의 다른 논문 (6건)
정신분열병과 P50서형석, 정영조, 이승환pp. 137-143주요우울장애에 대한 인지치료의 효과이강준pp. 144-152한국인 우울 장애 환자에서 Brain-Derived Neurotrophic Factor (BDNF)의 유전자 다형성과 항우울제의 장기 치료 반응이민수, 강이헌, 구재우, 백종우, 이화영pp. 162-169사회공포증과 세로토닌 수송체 유전자다형성과의 연관성 : 예비연구오강섭, 이민수, 이재헌, 임세원pp. 170-177알코올 의존 환자의 금단 증상에 영향을 미치는 도파민계 (DRD2, DAT, COMT) 유전자 다형성김호남, 이영식, 한덕현, 민경준, 나철, 최태영pp. 178-188
