본문 바로가기
KERD
논문KCI 등재

정신분열병 환자에서 Clozapine과 그 대사물들의 혈장농도 및 FMO3 유전자 변이

Plasma Concentrations of Clozapine and its Metabolites and FMO3 Variations in Korean Schizophrenic Patients

1

조회

0

다운로드

0

인용

0

참고문헌

키워드

주제분류정신과학

초록

Abstract

Objective: The relationship between the total daily dose of clozapine given and the plasma concentrations of clozapine and its metabolites and the effect of Glu158Lys (wild-type: Glu, 'H'; variant: Lys, 'h') and Glu308Gly (wild-type: Glu, 'D'; variant: Lys, 'd') variation in FMO3 gene on plasma concentrations of clozapine and its metabolites was studied in schizophrenic patients.

참고문헌 (35)

  1. "Clozapine,a novel antipsychotic agent", 324, pp.746~754 (1991)
  2. "Clozapine for the treatment-resistant schizophrenic:a double blind comparison with chlorpromazine", 45, pp.789~796 (1988)
  3. "A prospective study of clozapine in treatment-resistant schizophrenic patients"
  4. "The history of clozapine", pp.3~5 (1989)
  5. "Clozapine-induced agranulocytosis", 329, pp.162~167 (1993)
  6. "Clozapine in tardive dyskinesia:observations from human and animal model studies", 55, pp.102~106 (1994)
  7. "Clozapine in the treatment of psychotic mood disorders,schizoaffective disorder and schizophrenia", 52, pp.411~414 (1991)
  8. "Clozapine in severe mood disorder", 56, pp.411~417 (1995)
  9. "The use of clozapine in severe mood disorder", 55(9), pp.98~101 (1994)
  10. "Agranulocytosis in patients treated with clozapine", 56, pp.241~248 (1977)
  11. "Clozapine-induced agranulocytosis:a situation report up to August 1976", 11, pp.199~201 (1977)
  12. "Leponex-associated granulocytopenia:a review of the situation", 99, pp.118~121 (1989)
  13. "Clozapine-associated granulocytopenia:a review of the situation", 99 (1992)
  14. "Mechanism of clozapine-induced agranulocytosis", suppl 1, pp.17~25 (1992)
  15. "a clozapine metabolite that suppresses hematopoiesis", pp.555~561
  16. "Microsomal mixed-function amine oxidase:oxidation products of piperazine-substituted phenothiazine drugs", 6, pp.232~239 (1978)
  17. "A genetic polymorphism of the N-oxidation of trimethylamine in human", 42, pp.588~594 (1987)
  18. "The molecular biology of the flavin-containing monooxygenases of man", 96, pp.17~32 (1995)
  19. "Quantitation and kinetic properties of hepatic microsomal and recombinant flavin-containing monooxygenases 3 and 5 from humans", 106, pp.29~45 (1997)
  20. "Point mutation in flavin-containing monooxygenase 3 gene,FMO3,underlies fish-odour syndrome", 17, pp.491~494 (1997)
  21. "Characterization of two human flavin-containing monooxygenase(form 3)enzymes expressed in Escherichia Coli as maltose binding protein fusions", 25, pp.1001~1007 (1997)
  22. "N-Oxygenation of clozapine by flavin-containing monooxygenase", 25, pp.524~527 (1997)
  23. "Elucidation of individual cytochrome P450 enzymes involved in the metabolism of clozapine", 358, pp.592~599 (1998)
  24. "Examining concentration-dependent toxicity of clozapine:role of therapeutic drug monitoring", 11, pp.289~301 (2005)
  25. "Flavin-containing monooxygenase 3 (FMO3) polymorphism in a white population: allele frequencies, mutation linkage, and functional effects on clozapine and caffeine metabolism", 66, pp.431~438 (1999)
  26. "Phenotypes of flavin-containing monooxygenase activity determined by ranitidine N-oxidation are positively correlated with genotypes of linked FMO3 gene mutations in a Korean population", 10, pp.67~78 (2000)
  27. "Diagnostic and Statistical Mannual of Mental Disorders", pp.285~286 (1994)
  28. "Determination of clozapine,norclozapine,and clozapine N-oxide in serum by liquid chromatography", 39, pp.1656~1659 (1993)
  29. "General pharmacology of clozapine", 160(17), pp.5~11 (1992)
  30. "Neuroleptic affinities for human brain receptors and their use in predicting adverse effects", 45, pp.331~336 (1984)
  31. "Dose-related plasma levles of clozapine:influence of smoking behaviour,sex and age", 99 (1989)
  32. "Pharmacokotherapie und Alter", 25, pp.43~52 (1986)
  33. "Multiple-dose pharmacokinetics of clozapine in patients", 4, pp.402~405 (1987)
  34. "Clozapine and norclozapine plasma concentrations and clinical response of treatment-refractory schizophrenic patients", 148, pp.231~235 (1991)
  35. "Pharmacokinetics and pharmacodynamics of clozapine", 24, pp.161~176 (1993)

관련 논문AI추천

이 간행물의 다른 논문 (6건)