초발 주요우울장애 환자의 우울 삽화 및 관해 상태에서 신경인지기능 결함 비교
Comparison of neuropsychological deficitsbetween depressed episode and remission in first-onset patients with major depressive disorder
1
조회
0
다운로드
2
인용
0
참고문헌
초록
Objectives : The purpose of this study was to investigate 1) the neuropsychological deficits with major depressive disorder(MDD) on depressed state and 2) the changes of neuropsychological dysfunctions at depressed episodes and remitted periods in the MDD group. Methods : 12 patients with MDD and 70 normal controls who werediagnosed and classified by DSM-IV and SCID-IV interview were participated in this study. The psychopathology was measured using Hamilton rating scale for depression (HAM-D) and Brief Psychiatric Rating Scale (BPRS). The memory function, executive function, and sustained attention were measured by a trained psychologist usingKorean version of Memory Assessment Scale (K-MAS), Wisconsin Card Sorting Test (WCST), and Vigilance (VIG) and Cognitrone (COG) in Vienna Test System. After 6 weeks of treatment, we retested the cognitive tests in order to measure the cognitive functions at remitted states. Results : Patients with MDD achieved significantly lower score in sentence immediately recall, verbal memory score and total memory score of K-MAS, total errors of WCST, response time of Vigilance and response time at Yes response of Cognitrone than normal controls at baseline. After 6 weeks of medication, the psychiatric symptoms in patients group were attenuated, and most of the neuropsychological functions including attention, memory, and frontal/executive function were improved excepting for response time of Cognitrone. Conclusions : This study provides evidence for distinct neuropsychological deficits in patients with MDD on their depressed states and remitted periods. The impairment on response time remains after remission, and this would be a trait marker of major depressive disorder.
Abstract
Objectives : The purpose of this study was to investigate 1) the neuropsychological deficits with major depressive disorder(MDD) on depressed state and 2) the changes of neuropsychological dysfunctions at depressed episodes and remitted periods in the MDD group. Methods : 12 patients with MDD and 70 normal controls who werediagnosed and classified by DSM-IV and SCID-IV interview were participated in this study. The psychopathology was measured using Hamilton rating scale for depression (HAM-D) and Brief Psychiatric Rating Scale (BPRS). The memory function, executive function, and sustained attention were measured by a trained psychologist usingKorean version of Memory Assessment Scale (K-MAS), Wisconsin Card Sorting Test (WCST), and Vigilance (VIG) and Cognitrone (COG) in Vienna Test System. After 6 weeks of treatment, we retested the cognitive tests in order to measure the cognitive functions at remitted states. Results : Patients with MDD achieved significantly lower score in sentence immediately recall, verbal memory score and total memory score of K-MAS, total errors of WCST, response time of Vigilance and response time at Yes response of Cognitrone than normal controls at baseline. After 6 weeks of medication, the psychiatric symptoms in patients group were attenuated, and most of the neuropsychological functions including attention, memory, and frontal/executive function were improved excepting for response time of Cognitrone. Conclusions : This study provides evidence for distinct neuropsychological deficits in patients with MDD on their depressed states and remitted periods. The impairment on response time remains after remission, and this would be a trait marker of major depressive disorder.
참고문헌 (36)
- Klimes-Dougan B., "Neuropsychological Functioning in Adolescent Children of Mothers with a History of Bipolar or Major Depressive Disorders", Biological Psychiatry, 60, pp.957~965 (2006)
- Elliott R., "The neuropsychological profile in unipolar depression", Psychological Medicine, 2, pp.447~454 (1998)
- Elderkin-Thompson V., "Executive dysfunction and visuospatial ability among depressed elders in a community setting", Archives of Clinical Neuropsychology, 19, pp.597~611 (2004)
- Rogers MA., "Executive and prefrontal dysfunction in unipolar depression: a review of neuropsychological and imaging evidence", Neuroscience Research, 50, pp.1~11 (2004)
- Roiser JP., "Neuropsychology of mood disorders", Psychiatry, 5, pp.158~162 (2006)
- Fossati P., "Influence of age and executive functioning on verbal memory of inpatients with depression", Journal of Affective Disorders, 68, pp.261~271 (2002)
- Langenecker SA., "The sensitivity and psychometric properties of a brief computer-based cognitive screening battery in a depression clinic", Psychiatry Research, 152, pp.143~154 (2007)
- Ventura J., "User's Guide for the Structured Clinical Interview for DSM-IV Axis I Disorders SCID-I: Clinician Version", Psychiatry Research, 79, pp.163~173 (1997)
- Müller MJ., "Standardized rater training for the Hamilton Depression Rating Scale (HAMD-17) in psychiatric novices", Journal of Affective Disorders, 77, pp.65~69 (2003)
- Montgomery SA., "A new depression scale designed to be remitive to change (MADRS)", British Journal of Psychiatry, 134, pp.382~389 (1979)
- Hamilton M., "A rating scale for depression. Journal of Neurology", Neurosurgery and Psychiatry, 23, pp.56~62 (1960)
- Bremner JD., "Effects of antidepressant treatment on neural correlates of emotional and neutral declarative verbal memory in depression", Journal of Affective Disorders, 101, pp.99~111 (2007)
- Elderkin-Thompson V., "Executive dysfunction and memory in older patients with major and minor depression", Archives of Clinical Neuropsychology, 22, pp.261~270 (2007)
- Brody AL., "Prefrontal-subcortical and limbic circuit mediation of major depressive disorder", Seminars in Clinical Neuropsychiatry, 6, pp.102~112 (2001)
- Harrison PJ., "The neuropathology of primary mood disorder", Brain, 125, pp.1428~1449 (2002)
- Drevets WC., "Neuroimaging Studies of Mood Disorders", Biological Psychiatry, 48, pp.813~829 (2002)
- Beats BC., "Cognitive performance in tests sensitive to frontal lobe dysfunction in the elderly depressed", Psychological Medicine, 26, pp.591~604 (1996)
- Tham A., "Impaired neuropsychological performance in euthymic patients with recurring mood disorders", Journal of Clinical Psychiatry, 58, pp.26~29 (1997)
- Gruber S., "Stability and course of neuropsychological deficits in manic and depressed bipolar patients compared to patients with Major Depression", Journal of Affective Disorders, 104, pp.61~71 (2007)
- Opdyke KS., "Effect of continuation treatment on residual symptoms in late-life depression: how well is "well"?", Depression and Anxiety, 97, pp.312~319 (1996)
- Overall JE., "The Brief Psychiatric Rating Scale", Psychological Report, 10, pp.799~812 (1962)
- S Vienna Test System, "The PC", pp.1992, Schuhfried G.
- Lee HS., "A Preliminary Study on Standardization of K-MAS ( Korean version of Memory Assessment Scales)", Korean Journal of Clinical Psychology, 18, pp.221~241 (1999)
- Heaton RK., "Wisconsin Card Sorting Manual : Revised and expanded" (1993), Psychological Assessment Resources, Inc,
- Vakalopoulos C., "Neurocognitive deficits in major depression and a new theory of ADHD: A model of impaired antagonism of cholinergic-mediated prepotent behaviours in monoamine depleted individuals", Medical Hypotheses, 68, pp.210~221 (2007)
- Rose EJ., "Pattern of impaired working memory during major depression", Journal of Affective Disorders, 90, pp.149~161 (2006)
- Paelecke-Habermann Y., "Attention and executive functions in remitted major depression patients", Journal of Affective Disorders, 89, pp.125~135 (2005)
- Alexopoulos GS., "Executive Dysfunction and Long-term Outcomes of Geriatric Depression", Archives of General Psychiatry, 57, pp.285~290 (2000)
- Kalayam B., "Prefrontal Dysfunction and Treatment Response in Geriatric Depression", Archives of General Psychiatry, 56, pp.713~718 (1999)
- Davidson RJ., "DEPRESSION: Perspectives from Affective Neuroscience", Annual Review of Psychology, 53, pp.545~574 (2002)
- Smith MJ., "Retardation of mentation in depressives: Posner's covert orientation of visual attention test", Journal of Affective Disorders, 35, pp.107~115 (1995)
- Pardo JV., "Neurocognitive dysfunction in antidepressant-free, non-elderly patients with unipolar depression: Alerting and covert orienting of visuospatial attention", Journal of Affective Disorders, 92, pp.71~78 (2006)
- Fossati P., "Executive functioning and verbal memory in young patients with unipolar depression and schizophrenia", Psychiatry Research, 89, pp.171~187 (1999)
- Bearden CE., "Patterns of memory impairment in bipolar disorder and unipolar major depression", Psychiatry Research, 142, pp.139~150 (2006)
- Lawrie SM., "The difference in patterns of motor and cognitive function in chronic fatigue syndrome and severe depressive illness", Psychological Medicine, 30, pp.433~442 (2000)
- Miller EN., "Hemispheric asymmetries of function in patients with major affective disorders", Journal of Psychiatric Research, 29, pp.173~183 (1995)