기억력 저하를 호소하는 노인 우울증과 기억성 경도인지장애 환자에서 인지기능 특성의 비교
Characteristics of Cognitive Faculties in Elderly Depressive Patientscomplaining of Memory Decline and Patients with Amnestic Mild Cognitive Impairment
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Objectives:Elderly depression is often misdiagnosed as a dementing illness such as Alzheimer’s disease (AD). Moreover, de- pressive symptoms often are presented in the early phase of AD. It is difficult to distinguish the difference between mild cognitive impairment (MCI) and depression. The purpose of this study is to explore neuropsychological characteristics of patients with am- nestic MCI (aMCI) and depression. We hypothesized that there would be the difference in the cognitive function of those groups and this made clearer the nature of a depression and aMCI. Methods:A community dwelling older people aged over 60 years were enrolled for the study. We compared 24 patients with aMCI, 23 with depression complaining subjective memory decline, and 26 normal elderly. Demographic and neuropsychological data were gathered and assessed by trained psychologist. Results:PPatients with aMCI and depression had significant differences separately from normal controls in particular cogni- tive function. Patients with aMCI showed more cognitive declines in learning than normal older people. Patients with depression had less performance in attention and executive function than normal controls. Conclusion:To understand the clinical difference and underlying pathophysiology of aMCI and depression, the precise crite- ria of aMCI gathering more homogeneous group of depression in severity and onset time will be needed.
Abstract
Objectives:Elderly depression is often misdiagnosed as a dementing illness such as Alzheimer’s disease (AD). Moreover, de- pressive symptoms often are presented in the early phase of AD. It is difficult to distinguish the difference between mild cognitive impairment (MCI) and depression. The purpose of this study is to explore neuropsychological characteristics of patients with am- nestic MCI (aMCI) and depression. We hypothesized that there would be the difference in the cognitive function of those groups and this made clearer the nature of a depression and aMCI. Methods:A community dwelling older people aged over 60 years were enrolled for the study. We compared 24 patients with aMCI, 23 with depression complaining subjective memory decline, and 26 normal elderly. Demographic and neuropsychological data were gathered and assessed by trained psychologist. Results:PPatients with aMCI and depression had significant differences separately from normal controls in particular cogni- tive function. Patients with aMCI showed more cognitive declines in learning than normal older people. Patients with depression had less performance in attention and executive function than normal controls. Conclusion:To understand the clinical difference and underlying pathophysiology of aMCI and depression, the precise crite- ria of aMCI gathering more homogeneous group of depression in severity and onset time will be needed.
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