노인성 우울증 환자와 정상 노인에서 인지기능의 비교 및 우울증 증상 변화와의 관련성 평가
Comparisons of Neurocognitive Functions in Patients with Late-Life Depression versus Normal Elderly, and Association with Changes of Depressive Symptoms in a 3-Month Follow-Up
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Objective:This study aimed to investigate the neurocognitive functions of patients with late-life depression compared to healthy controls and their association with improvement of depressive symptoms. Methods:We compared the results of neurocognitive tests between 41 patients with late-life depression and 20 healthy controls at baseline and 3 months later prospectively. And then we investigated the association of change of cognitive function and improvement of depressive symptoms in patients with late-life depression. Results:Patients with late-life depression showed significantly impaired results in neurocognitive tests especially in domains of language, memory and frontal executive function compared to healthy control. However, after 3 months of treatment of depression, there was no association between the change of results of neurocognitive tests and the changes of scores of Hamilton Depression Rating Scale (HAM-D). Conclusion:Impairment of cognitive functions in late-life depression includes the domains of language, memory and executive function and after 3 months of treatment of depression, there was no association of improvement of depressive symptom and cognitive change in patients with late-life depression.
Abstract
Objective:This study aimed to investigate the neurocognitive functions of patients with late-life depression compared to healthy controls and their association with improvement of depressive symptoms. Methods:We compared the results of neurocognitive tests between 41 patients with late-life depression and 20 healthy controls at baseline and 3 months later prospectively. And then we investigated the association of change of cognitive function and improvement of depressive symptoms in patients with late-life depression. Results:Patients with late-life depression showed significantly impaired results in neurocognitive tests especially in domains of language, memory and frontal executive function compared to healthy control. However, after 3 months of treatment of depression, there was no association between the change of results of neurocognitive tests and the changes of scores of Hamilton Depression Rating Scale (HAM-D). Conclusion:Impairment of cognitive functions in late-life depression includes the domains of language, memory and executive function and after 3 months of treatment of depression, there was no association of improvement of depressive symptom and cognitive change in patients with late-life depression.
참고문헌 (38)
- World Health Organization, "Depression and other common mental disorders: global health estimates" (2017), World Health Organization
- Ministry of Health and Welfare, "The survey of mental disorders in Korea" (2017), Ministry of Health and Welfare
- clinical psychiatry, "Synopsis of psychiatry: behavioral sciences", pp.2015, Sadock BJ
- Cause of death statistics of 2016, "Statistics Korea", Statics Korea, ~ (2017)
- Elderly statistics of 2017, "Statistics Korea", Statics Korea, ~ (2017)
- Committee on the Mental Health Workforce for Geriatric Populations, "The mental health and substance use workforce for older adults: in whose hands?" (2012), National Academies Press (US)
- Beekman AT, "Review of community prevalence of depression in later life", Br J Psychiatry, 174, pp.307~311 (1999)[DOI]
- Blazer DG, "Depression in late life: review and commentary", J Gerontol A Biol Sci Med Sci, 58, pp.249~265 (2003)[DOI]
- Van Damme A, "Late-life depression: issues for the general practitioner", Int J Gen Med, 11, pp.113~120 (2018)[DOI]
- Gottfries CG, "Is there a difference between elderly and younger patients with regard to the symptomatology and aetiology of depression?", Int Clin Psychopharmacol, 13(Suppl 5), pp.S13~S18 (1998)
- Reynolds CF 3rd, "Chronic depression in the elderly: approaches for prevention", Drugs Aging, 18, pp.507~514 (2001)[DOI]
- Butters MA, "The nature and determinants of neuropsychological functioning in late-life depression", Arch Gen Psychiatry, 61, pp.587~595 (2004)[DOI]
- Sheline YI, "Cognitive function in late life depression: relationships to depression severity, cerebrovascular risk factors and processing speed", Biol Psychiatry, 60, pp.58~65 (2006)[DOI]
- Wang S, "Depression and cognition in the elderly", Annu Rev Clin Psychol, 11, pp.331~360 (2015)[DOI]
- Byers AL, "Depression and risk of developing dementia", Nat Rev Neurol, 7, pp.323~331 (2011)[DOI]
- Steenland K, "Late-life depression as a risk factor for mild cognitive impairment or Alzheimer's disease in 30 US Alzheimer's disease centers", J Alzheimers Dis, 31, pp.265~275 (2012)[DOI]
- Jeon HJ, "Improvement in subjective and objective neurocognitive functions in patients with major depressive disorder: a 12-week, multicenter, randomized trial of tianeptine versus escitalopram, the CAMPION study", J Clin Psychopharmacol, 34, pp.218~225 (2014)[DOI]
- Steffens DC, "Outcomes of older cognitively impaired individuals with current and past depression in the NCODE study", J Geriatr Psychiatry Neurol, 22, pp.52~61 (2009)[DOI]
- Denburg NL, "The orbitofrontal cortex, real-world decision making, and normal aging", Ann N Y Acad Sci, 1121, pp.480~498 (2007)[DOI]
- Koenig AM, "Cognitive functioning and late-life depression", J Int Neuropsychol Soc, 20, pp.461~467 (2014)[DOI]
- Sneed JR, "Antidepressant medication and executive dysfunction: a deleterious interaction in late-life depression", Am J Geriatr Psychiatry, 18, pp.128~135 (2010)[DOI]
- Baba K, "Executive dysfunction in remitted late-life depression: Juntendo University Mood Disorder Projects (JUMP)", J Neuropsychiatry Clin Neurosci, 22, pp.70~74 (2010)[DOI]
- Jaeger J, "Neurocognitive deficits and disability in major depressive disorder", Psychiatry Res, 145, pp.39~48 (2006)[DOI]
- Sheehan DV, "The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10", J Clin Psychiatry, 59(Suppl 20), pp.22~33 (1998)
- Hamilton M, "Development of a rating scale for primary depressive illness", Br J Soc Clin Psychol, 6, pp.278~296 (1967)[DOI]
- Park JH, "Modification of the mini-mental state examination for use in the elderly in a non-western society. part 1. development of Korean version of mini-mental state examination", Int J Geriatr Psychiatry, 5, pp.381~387 (1990)[DOI]
- Guy W, "ECDEU assessment manual for psychopharmacology-revised" (1976), US Department of Health, Education, and Welfare
- Kang Y, "Seoul neuropsychological screening battery. (SNSB-II)" (2012), Human Brain Research & Consulting Co
- Lee JY, "Brief screening for mild cognitive impairment in elderly outpatient clinic: validation of the Korean version of the Montreal Cognitive Assessment", J Geriatr Psychiatry Neurol, 21, pp.104~110 (2008)[DOI]
- 서은현, "치매 및 인지장애에서의 신경심리평가", 신경정신의학, 57(1), pp.2~11 (2018), 대한신경정신의학회[DOI]
- Butters MA, "Pathways linking late-life depression to persistent cognitive impairment and dementia", Dialogues Clin Neurosci, 10, pp.345~357 (2008)
- Morimoto SS, "Cognitive deficits in geriatric depression: clinical correlates and implications for current and future treatment", Psychiatr Clin North Am, 36, pp.517~531 (2013)[DOI]
- Salloway S, "MRI and neuropsychological differences in early- and late-life-onset geriatric depression", Neurology, 46, pp.1567~1574 (1996)[DOI]
- Picton JD, "Benzodiazepine use and cognitive decline in the elderly", Am J Health Syst Pharm, 75, pp.6~12 (2018)[DOI]
- Doraiswamy PM, "Does antidepressant therapy improve cognition in elderly depressed patients?", J Gerontol A Biol Sci Med Sci, 58, pp.M1137~M1144 (2003)[DOI]
- Basso M, "Secondary influences on neuropsychological test performance", pp.39~66 (2013), Oxford University Press
- Bhalla RK, "Persistence of neuropsychologic deficits in the remitted state of late-life depression", Am J Geriatr Psychiatry, 14, pp.419~427 (2006)[DOI]
- Barch DM, "Cognitive improvement following treatment in latelife depression: relationship to vascular risk and age of onset", Am J Geriatr Psychiatry, 20, pp.682~690 (2012)[DOI]
