백신 접종 스트레스 완화제의 소 구제역 백신접종에 따른 부작용 완화 효과
Effect of Vaccine Side Effects Mitigating Agents on Foot-and-mouth Disease Vaccination Stress in Bovine
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본 연구는 아세트아미노펜, 비타민C, 무수구연산으로 구성된 백신 스트레스 저감제, 피버닐 산(FeverNil powder)이 소 구제역 백신 접종 후 부작용 저감에 미치는 영향을 규명하고자 실시하였다. 3개월령 송아지 30두를 공시하여 10두씩 3그룹 [대조군, 백신접종군(A 그룹), 백신+약물투여군(B 그룹)]으로 배치하였다. B 그룹에는 백신 접종 후 5일간 0.2%의 피버닐 산을 혼합하여 사료를 급여하였다. 백신투여 당일과 백신 투여 후 1일, 3일, 7일, 10일, 14일에 가축의 체중, 사료 섭취량, 임상증상, 혈액학치 및 혈액화학치, 혈청 내 스트레스 및 염증관련 인자 분석을 진행하였다. 실험 기간 중 총 증체량과 일일 평균 증체량은 B 그룹에서 각 13.57±0.98kg, 0.97±0.07kg/day로 A 그룹(12.00±1.15kg, 0.86±0.08kg/day)에 비해 유의적으로 증가하였다(p<0.05). 혈청 내 FMDV 항체가는 두 백신 접종군 사이에 유의한 차이를 보이지 않았으나, 피버닐 투여군의 항체가가 비투여군에 비해 높게 증가하는 경향을 보였다. 혈청 내 염증 전 단계 사이토카인 TNF-α 값은 실험 5일 차에 A 그룹 74.47±19.26pg/ml, B 그룹 59.05±11.88pg/ml로 B 그룹이 A 그룹에 비해 유의적으로 낮게 측정되었으며(p<0.05), cortisol 농도 또한 B 그룹이 A 그룹에 비해 유의적으로 낮게 측정되었다(p<0.05). 연구 결과로 보아 피버닐 산의 급여는 FMD 백신 접종에 의한 부작용 완화에 도움이 되는 것으로 판단되며, 이에 따라 백신 접종에 의한 생산성 저하를 막아줄 수 있는 것으로 사료된다.
Abstract
This study evaluated whether fevernill, which is primarily composed of acetaminophen, vitamin C, and anhydrous citric acid, is effective in relieving stress caused by foot-and-mouth disease virus (FMDV) vaccination in calves. Three-month-old calves from a farm in Korea were randomly assigned to one of three groups (n = 10 per group: control [untreated], group A [FMDV vaccination], and group B [FMDV vaccination + addition of fevernill 0.2% to feed for five days after vaccination]). Body weights, antibody formation, clinical symptoms, serum parameters were measured in the 14 days following vaccination. Total weight gain and average daily gain during the experiment period were group A (12.00±1.15 kg, 0.86±0.08 kg/day) compared to group B (13.57±0.98 kg, 0.97±0.07 kg/day) was significantly improved (p<0.05). There was no significant difference in the formation of antibodies against the FMDV vaccine between group A and group B, though the antibody value of group B tended to be higher than that of group A. The pre-inflammatory cytokine TNF-α value was 74.47±19.26 pg/ml in group A and 59.05±11.88 pg/ml in group B on the 5th day of the experiment, which was significantly lower in group B than in group A (p<0.05). Also, cortisol concentrations were significantly lower in group B than in group A (p<0.05). In conclusion, the feeding of fevernil is judged to be helpful in mitigating the side effects caused by FMD vaccination, and thus it is thought to be able to prevent the decrease in productivity caused by vaccination.
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